Chuanzhi Duan
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View article: Comparison of Stent-assisted Coiling and Coiling Alone for Acutely Ruptured Intracranial Aneurysms:The SANE Multicenter Registry
Comparison of Stent-assisted Coiling and Coiling Alone for Acutely Ruptured Intracranial Aneurysms:The SANE Multicenter Registry Open
Background Evidence from large, prospective studies in treating ruptured intracranial aneurysms (RIAs) using stent-assisted coiling (SAC) technique is lacking, biases and uncertainty regarding the safety of SAC persist. We aimed to evaluat…
View article: Effect of LDL-Cholesterol Levels and Oral Atorvastatin on Outcomes After Pipeline Therapy for Intracranial Aneurysms
Effect of LDL-Cholesterol Levels and Oral Atorvastatin on Outcomes After Pipeline Therapy for Intracranial Aneurysms Open
BACKGROUND: We aimed to determine the effects of statin treatment on outcomes of pipeline embolization device therapy for intracranial aneurysms in relation to LDL (low-density lipoprotein) cholesterol levels. METHODS: Using data from the …
View article: Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke
Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke Open
View article: Stent match of pipeline embolization device: prediction of incomplete occlusion and in-stent stenosis by actual stent size after implantation
Stent match of pipeline embolization device: prediction of incomplete occlusion and in-stent stenosis by actual stent size after implantation Open
View article: Fibrinogen Levels Below a Critical Threshold Serve as a Protective Factor Against In-Stent Stenosis Following Flow Diverter Treatment for Intracranial Aneurysms: A Multicenter Retrospective Cohort Study
Fibrinogen Levels Below a Critical Threshold Serve as a Protective Factor Against In-Stent Stenosis Following Flow Diverter Treatment for Intracranial Aneurysms: A Multicenter Retrospective Cohort Study Open
Low admission FIB (< 2.71 g/L) independently predicts ISS risk after FD treatment. With each additional unit of FIB level, there was a 73% reduction in the risk of ISS after FD treatment at follow-up. These results may help identify patien…
View article: Safety and Efficacy of Endovascular Thrombectomy for Acute Ischemic Stroke After Cardiac Surgery: A Retrospective Analysis of Readmission Nationwide Database Data
Safety and Efficacy of Endovascular Thrombectomy for Acute Ischemic Stroke After Cardiac Surgery: A Retrospective Analysis of Readmission Nationwide Database Data Open
Background There is limited evidence regarding outcomes of endovascular thrombectomy (EVT) in patients with acute ischemic stroke after cardiac surgery (CS). Therefore, we aimed to evaluate the outcomes of EVT in patients with acute ischem…
View article: Association of B cells and the risk of glioblastoma: a bidirectional two sample mendelian randomization study
Association of B cells and the risk of glioblastoma: a bidirectional two sample mendelian randomization study Open
Background Glioblastoma (GBM) represents an exceptionally aggressive form of primary malignant brain neoplasm, distinguished by its rapid growth kinetics, unfavorable prognostic indicators, and associated high mortality rates. To date, the…
View article: Immune cell-mediated CETP gene and the causal relationship with ischemic stroke disease risk: Mendelian randomization analysis with mediation effect assessment
Immune cell-mediated CETP gene and the causal relationship with ischemic stroke disease risk: Mendelian randomization analysis with mediation effect assessment Open
Background: The advancement of cholesterol ester transfer protein inhibitors in the treatment of coronary heart disease (CHD) has thus far failed to produce approved therapeutic agents, despite Mendelian randomization (MR) studies establis…
View article: Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage
Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage Open
View article: Effect of cavitation on vortex-induced vibration of hydrofoil
Effect of cavitation on vortex-induced vibration of hydrofoil Open
Vortex induced vibration (VIV) is frequently observed in marine structures in offshore platforms, ships and other structures. Under specific circumstances, the vortex shedding frequency is locked into the natural frequency of the structure…
View article: Nrf-2 modulates excitability of hippocampal neurons by regulating ferroptosis and neuroinflammation after subarachnoid hemorrhage in rats
Nrf-2 modulates excitability of hippocampal neurons by regulating ferroptosis and neuroinflammation after subarachnoid hemorrhage in rats Open
Excitability of hippocampal neurons in subarachnoid hemorrhage (SAH) rats has not been well studied. The rat SAH model was applied in this study to explore the role of nuclear factor E2-related factor (Nrf-2) in the early brain injury of S…
View article: Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis
Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis Open
JOURNAL/nrgr/04.03/01300535-202405000-00035/inline-graphic1/v/2023-09-28T063346Z/r/image-tiff Subarachnoid hemorrhage is associated with high morbidity and mortality and lacks effective treatment. Pyroptosis is a crucial mechanism underlyi…
View article: CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway
CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway Open
View article: p97 inhibited integrative stress response-induced neuronal apoptosis by enhancing proteasome function after subarachnoid hemorrhage
p97 inhibited integrative stress response-induced neuronal apoptosis by enhancing proteasome function after subarachnoid hemorrhage Open
Neuronal apoptosis is a common pathological change in early brain injury after subarachnoid hemorrhage (SAH) and is closely associated with neurological deficits. Some research has shown that p97 exhibits a significant anti-cardiomyocyte a…
View article: A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm
A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm Open
Background and purpose Recent observational studies have reported that serum total homocysteine (tHcy) is associated with intracranial aneurysms (IAs). However, the causal effect of tHcy on IAs is unknown. We leveraged large-scale genetic …
View article: Early administration of multiple vasopressors is associated with better survival in patients with sepsis: a propensity score-weighted study
Early administration of multiple vasopressors is associated with better survival in patients with sepsis: a propensity score-weighted study Open
Background The association between the timing of administration of multiple vasopressors and patient outcomes has not been investigated. Methods This study used data from the MIMIC-IV database. Patients with sepsis who were administered tw…
View article: Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation
Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation Open
View article: Rupture discrimination of multiple small (< 7 mm) intracranial aneurysms based on machine learning-based cluster analysis
Rupture discrimination of multiple small (< 7 mm) intracranial aneurysms based on machine learning-based cluster analysis Open
View article: Association between central venous pressure measurement and outcomes in critically ill patients with severe coma
Association between central venous pressure measurement and outcomes in critically ill patients with severe coma Open
View article: Additional file 1 of Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation
Additional file 1 of Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation Open
Additional file 1.
View article: VEGF combined with DAPT promotes tissue regeneration and remodeling in vascular grafts
VEGF combined with DAPT promotes tissue regeneration and remodeling in vascular grafts Open
Previous research on tissue-engineered blood vessels (TEBVs) has mainly focused on the intima or adventitia unilaterally, neglecting the equal importance of both layers. Meanwhile, the efficacy of grafts modified with vascular endothelial …
View article: Cellular energy supply for promoting vascular remodeling of small-diameter vascular grafts: a preliminary study of a new strategy for vascular graft development
Cellular energy supply for promoting vascular remodeling of small-diameter vascular grafts: a preliminary study of a new strategy for vascular graft development Open
AICAR strengthened cellular energy supply and stimulated macrophages toward an M2 anti-inflammatory phenotype; thus AICAR-modified grafts achieved better vascular remodeling.
View article: Development and Validation of a Deep Learning Model to Predict Intracranial Aneurysm Instability: A Multicenter, Ambispective, Longitudinal Study
Development and Validation of a Deep Learning Model to Predict Intracranial Aneurysm Instability: A Multicenter, Ambispective, Longitudinal Study Open
View article: Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms
Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms Open
Background Gut microbiome has recently been recognized as an important environmental factor affecting the occurrence and development of unruptured intracranial aneurysms (UIA). This study aimed to investigate the relationship between gut m…
View article: Flow diversion treatment for giant intracranial serpentine aneurysms
Flow diversion treatment for giant intracranial serpentine aneurysms Open
Background Giant serpentine aneurysms (GSAs) are among the most complex and challenging type of intracranial aneurysms. Surgical clipping, bypass, or endovascular parent artery occlusion has been the main treatment of GSAs in the past. How…
View article: Use of covered stents to treat complex cerebrovascular diseases: Expert consensus
Use of covered stents to treat complex cerebrovascular diseases: Expert consensus Open
The treatment of complex cerebrovascular diseases (CCVDs) at the skull base, such as complex intracranial aneurysms, carotid-cavernous sinus fistulas, and intracranial artery traumatic injuries, is a difficult clinical problem despite adva…
View article: Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma
Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a complex issue in cancer treatment in the world at present. Matrine is the main active ingredient isolated from Sophora flavescens air and possesses excellent antitumor effects in HCC. However, the specif…
View article: Dexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K/AKT/GSK3β Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats
Dexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K/AKT/GSK3β Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats Open
Subarachnoid hemorrhage (SAH) is one kind of life-threatening stroke, which leads to severe brain damage. Pyroptosis plays a critical role in early brain injury (EBI) after SAH. Previous reports suggest that SAH-induced brain edema, cell a…
View article: Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats
Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats Open
Adiponectin (APN), a fat-derived plasma hormone, is a classic anti-inflammatory agent. Multiple studies have demonstrated the beneficial role of APN in acute brain injury, but the effect of APN in germinal matrix hemorrhage (GMH) is unclea…
View article: Plasma metabolic signatures for intracranial aneurysm and its rupture identified by pseudotargeted metabolomics
Plasma metabolic signatures for intracranial aneurysm and its rupture identified by pseudotargeted metabolomics Open
Background Whole-body metabolism is emerging as a critical player in the pathophysiology of intracranial aneurysms (IAs). However, the vital metabolic signatures for IA risk stratification and its potential biological underpinnings remain …