Explanipedia

The effect of resistance training for older adults with cognitive frailty: a randomized controlled trial Open

Ting Wu, Xiaoxia Wang, Yifei Xu, Chufan Zhang, MeiZhen Huang , et al. · 2025

ChiCTR2100043826 was registered on 4 March 2021.

Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy Open

Chaxian Liu, Yue Liu, Hao Lin, Chufan Zhang, Bilong Zhang , et al. · 2025

Introduction H3K27-altered diffuse midline glioma (DMG) is a highly aggressive glioma subtype, accounting for approximately 60% of pediatric high-grade gliomas, with a median survival of less than 12 months. Due to its predominant localiza…

Subgroups of mild cognitive impairment based on cognitive function among Chinese older adults Open

Yi Zhou, Yuanjiao Yan, Rong Lin, Yuting Luo, Zhenzhen Cai , et al. · 2024

Background: Due to the heterogeneity of mild cognitive impairment (MCI), the key points for nonpharmaceutical therapies cannot be determined. Examining impairment characteristics among different MCI subgroups would therefore be beneficial …

Decoding Cancer Evolution: Integrating Genetic and Non-Genetic Insights Open

Arghavan Ashouri, Chufan Zhang, Federico Gaiti · 2023

The development of cancer begins with cells transitioning from their multicellular nature to a state akin to unicellular organisms. This shift leads to a breakdown in the crucial regulators inherent to multicellularity, resulting in the em…

Subgroups of mild cognitive impairment based on cognitive function among Chinese older adults: a latent classes analysis Open

Yi Zhou, Rong Lin, Yuanjiao Yan, Yuting Luo, Zhenzhen Cai , et al. · 2022

Background: Due to the heterogeneity of MCI, the key points of non-drug therapies cannot be determined. Exploring the characteristics among different MCI subgroups would therefore be beneficial in guiding the development of non-drug therap…

A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity Open

Lanlin Zhang, Jiangyuan Du, Qian Song, Chufan Zhang, Xianghua Wu · 2022

Dendritic cell- (DC-) based vaccination has emerged as a promising antitumour immunotherapy. However, overcoming immune tolerance and immunosuppression in the tumour microenvironment (TME) is still a great challenge. Recent studies have sh…

PIK3CA Is Regulated by CUX1, Promotes Cell Growth and Metastasis in Bladder Cancer via Activating Epithelial-Mesenchymal Transition Open

Zhongyu Wang, Jun Shang, Zhiqin Li, Huanhuan Li, Chufan Zhang , et al. · 2020

PIK3CA is a key component of phosphatidylinositol 3-kinase (PI3K) pathway that its involvement in tumorigenesis has been revealed by previous research. However, its functions and potential mechanisms in bladder cancer are still largely und…

Development of a nomogram for preoperative prediction of lymph node metastasis in non-small cell lung cancer: a SEER-based study Open

Chufan Zhang, Qian Song, Lanlin Zhang, Xianghua Wu · 2020

We developed a convenient clinical prediction model for regional lymph node metastases in NSCLC patients. The nomogram will help physicians to determine which patients will receive the most benefit from lymph node dissection.

A novel risk score system of immune genes associated with prognosis in endometrial cancer Open