Chugang Mei
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View article: Incorporation alfalfa with annual forage enhances even water use and maintains forage yield resilience in a semiarid region
Incorporation alfalfa with annual forage enhances even water use and maintains forage yield resilience in a semiarid region Open
View article: <i>CircGLIS3</i> Inhibits Intramuscular Adipogenesis and Alleviates Skeletal Muscle Fat Infiltration
<i>CircGLIS3</i> Inhibits Intramuscular Adipogenesis and Alleviates Skeletal Muscle Fat Infiltration Open
Background Intramuscular fat (IMF) is a key determinant of meat quality. Excessive IMF deposition, commonly observed in human obesity and aging, negatively affects skeletal muscle function. Circular RNAs (circRNAs) play critical regulatory…
View article: Transcriptomic and metabolomic profiling reveals genotype-dependent alkali tolerance in triticale roots: amino acid, flavonoid, and betalain metabolism linked to gene networks
Transcriptomic and metabolomic profiling reveals genotype-dependent alkali tolerance in triticale roots: amino acid, flavonoid, and betalain metabolism linked to gene networks Open
These gene, metabolite, and pathway resources depict the internal responsive atlas of triticale under alkaline stress. Those involved in the metabolism of key amino acids, flavonoids, and betalains as mentioned above represent prior target…
View article: Sex-specific microbiota associations with backfat thickness, eye muscle area, and rumen fermentation in Qinchuan cattle
Sex-specific microbiota associations with backfat thickness, eye muscle area, and rumen fermentation in Qinchuan cattle Open
View article: Evaluating Genome Assemblies for Optimized Completeness and Accuracy of Reference Gene Sequences in Wheat, Rye, and Triticale
Evaluating Genome Assemblies for Optimized Completeness and Accuracy of Reference Gene Sequences in Wheat, Rye, and Triticale Open
Recent years have witnessed a surge in the publication of dozens of genome assemblies for Triticeae crops, which have significantly advanced gene-related research in wheat, rye, and triticale. However, this progress has also introduced cha…
View article: Riboflavin transporter deficiency: AAV9-SLC52A2 gene therapy as a new therapeutic strategy
Riboflavin transporter deficiency: AAV9-SLC52A2 gene therapy as a new therapeutic strategy Open
Riboflavin transporter deficiency syndrome (RTD) is a rare childhood-onset neurodegenerative disorder caused by mutations in SLC52A2 and SLC52A3 genes, encoding the riboflavin (RF) transporters hRFVT2 and hRFVT3. In the present study we fo…
View article: A novel interpretable deep learning-based computational framework designed synthetic enhancers with broad cross-species activity
A novel interpretable deep learning-based computational framework designed synthetic enhancers with broad cross-species activity Open
Enhancers play a critical role in dynamically regulating spatial-temporal gene expression and establishing cell identity, underscoring the significance of designing them with specific properties for applications in biosynthetic engineering…
View article: Identification of key genes and metabolites involved in meat quality performance in Qinchuan cattle by WGCNA
Identification of key genes and metabolites involved in meat quality performance in Qinchuan cattle by WGCNA Open
Understanding the genetic and metabolic elements that impact meat quality is crucial to improving production and meeting consumer demands in the beef sector. Differences in meat quality among various muscle areas in beef cattle can impact …
View article: <i>LEP</i> inhibits intramuscular adipogenesis through the <scp>AMPK</scp> signaling pathway in vitro
<i>LEP</i> inhibits intramuscular adipogenesis through the <span>AMPK</span> signaling pathway in vitro Open
Leptin can indirectly regulate fatty‐acid metabolism and synthesis in muscle in vivo and directly in incubated muscle ex vivo. In addition, non‐synonymous mutations in the bovine leptin gene ( LEP ) are associated with carcass intramuscula…
View article: Genome-wide analysis reveals genomic diversity and signatures of selection in Qinchuan beef cattle
Genome-wide analysis reveals genomic diversity and signatures of selection in Qinchuan beef cattle Open
View article: Arginine (315) is required for the PLIN2-CGI-58 interface and plays a functional role in regulating nascent LDs formation in bovine adipocytes
Arginine (315) is required for the PLIN2-CGI-58 interface and plays a functional role in regulating nascent LDs formation in bovine adipocytes Open
Perilipin-2 (PLIN2) can anchor to lipid droplets (LDs) and play a crucial role in regulating nascent LDs formation. Bimolecular fluorescence complementation (BiFC) and flow cytometry were examined to verify the PLIN2-CGI-58 interaction eff…
View article: New Insight for Riboflavin Transporter Deficiency: Aav9-Slc52a2 Gene Therapy as a New Therapeutic Strategy
New Insight for Riboflavin Transporter Deficiency: Aav9-Slc52a2 Gene Therapy as a New Therapeutic Strategy Open
View article: Genome-Wide Association Study Reveals Novel Loci Associated with Body Conformation Traits in Qinchuan Cattle
Genome-Wide Association Study Reveals Novel Loci Associated with Body Conformation Traits in Qinchuan Cattle Open
A genome-wide association study (GWAS) is an effective tool for identifying the dominant genes of complex economic traits in livestock by statistical analysis of genotype data and measured phenotype data. In this study, we rigorously measu…
View article: Integrated multi-omics analysis reveals variation in intramuscular fat among muscle locations of Qinchuan cattle
Integrated multi-omics analysis reveals variation in intramuscular fat among muscle locations of Qinchuan cattle Open
Background Intramuscular fat (IMF) is closely related to the tenderness, marbling, juiciness, and flavor of meat. We used a combined transcriptome and metabolome analysis to investigate the molecular mechanisms underlying phenotypic variat…
View article: Integrative Analysis of Blood Transcriptomics and Metabolomics Reveals Molecular Regulation of Backfat Thickness in Qinchuan Cattle
Integrative Analysis of Blood Transcriptomics and Metabolomics Reveals Molecular Regulation of Backfat Thickness in Qinchuan Cattle Open
A crucial goal of reducing backfat thickness (BFT) is to indirectly improve feed conversion efficiency. This phenotype has been reported in certain papers; however, the molecular mechanism has yet to be fully revealed. Two extreme BFT grou…
View article: RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Background Long non-coding RNAs (lncRNAs) regulate numerous biological processes, including adipogenesis. Research on adipogenesis will assist in the treatment of human metabolic diseases and improve meat quality in livestock, such as the …
View article: Additional file 7 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 7 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 7. DELs between 4 adipogenesis stages.
View article: Additional file 4 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 4 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 4. Sequencing data validated by qRT-PCR.
View article: Additional file 10 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 10 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 10. Correlation between mRNA and BIANCR.
View article: Additional file 9 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 9 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 9. Module information of WGCNA.
View article: Additional file 5 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 5 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 5. Correlation analysis between samples.
View article: Additional file 8 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 8 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 8. GO terms and KEGG pathways for DELs.
View article: Additional file 2 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 2 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 2. Primers used in PCR and qRT-PCR.
View article: Additional file 3 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 3 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 3. Antibody information.
View article: Additional file 2 of Integrated multi-omics analysis reveals variation in intramuscular fat among muscle locations of Qinchuan cattle
Additional file 2 of Integrated multi-omics analysis reveals variation in intramuscular fat among muscle locations of Qinchuan cattle Open
Additional file 2.
View article: Additional file 12 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 12 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 12. The sequence of BIANCR.
View article: Additional file 1 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 1 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 1. Reads information of RNA-seq.
View article: Additional file 6 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 6 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 6. Type information of lncRNA.
View article: Additional file 11 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway
Additional file 11 of RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway Open
Additional file 11. GO terms and KEGG pathways for BIANCR.
View article: A genome-wide landscape of mRNAs, lncRNAs, circRNAs and miRNAs during intramuscular adipogenesis in cattle
A genome-wide landscape of mRNAs, lncRNAs, circRNAs and miRNAs during intramuscular adipogenesis in cattle Open