Chuiguo Huang
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View article: Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches
Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches Open
Objective To identify contraindicated medications and corresponding target genes for migraine and its subtypes. Method Utilizing the Genome‐Wide Association Studies (GWAS) for 14 medication‐use categories from UK Biobank and GWAS for migra…
View article: Integrative multi-omics and causal inference unveil novel therapeutic targets for primary sclerosing cholangitis and its genetic comorbidity with inflammatory bowel disease
Integrative multi-omics and causal inference unveil novel therapeutic targets for primary sclerosing cholangitis and its genetic comorbidity with inflammatory bowel disease Open
Primary sclerosing cholangitis (PSC), a progressive liver disease with limited treatment options, exhibits frequent comorbidity with inflammatory bowel disease (IBD), yet shared therapeutic targets remain unexplored. Leveraging integrative…
View article: Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis
Participant characteristics in the effectiveness of lifestyle interventions to optimize gestational weight gain: a systematic review and meta-analysis Open
Lifestyle interventions reduced excessive GWG, with possible differential effects by intervention initiation time, BMI, and HDL-C. Future studies should consider physiological as well as social characteristics, in line with a holistic fram…
View article: Identifying Causal Inflammatory Factors With Gene Mediators and Potential Drugs for Bronchiectasis
Identifying Causal Inflammatory Factors With Gene Mediators and Potential Drugs for Bronchiectasis Open
Background Bronchiectasis is a chronic respiratory disease characterized by irreversible dilation of the bronchi. Despite advancements in diagnostic techniques and therapeutic strategies, the underlying etiological factors driving bronchie…
View article: Global, regional, and country-specific lifetime risks of osteoarthritis, 1990–2021: a systematic analysis for the global burden of disease study 2021
Global, regional, and country-specific lifetime risks of osteoarthritis, 1990–2021: a systematic analysis for the global burden of disease study 2021 Open
Background Osteoarthritis (OA) is a leading cause of disability worldwide, yet global estimates of lifetime risk remain limited. This study aims to provide comprehensive global, regional, and national lifetime risk estimates for OA, includ…
View article: Population-level productivity-adjusted life years lost in individuals with type 2 diabetes in Hong Kong: a life table modelling study
Population-level productivity-adjusted life years lost in individuals with type 2 diabetes in Hong Kong: a life table modelling study Open
Direct Grant for Research from The Chinese University of Hong Kong.
View article: Trends and Disparities in Cardiovascular Disease in US Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease
Trends and Disparities in Cardiovascular Disease in US Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Background/Objectives: Recently, the term metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced non-alcoholic fatty liver disease (NAFLD). Through analysis of the trends and disparities regarding cardiovascular dise…
View article: Identifying and visualising temporal trajectories of hospitalisations for traditional and non-traditional complications in people with type 2 diabetes: a population-based study
Identifying and visualising temporal trajectories of hospitalisations for traditional and non-traditional complications in people with type 2 diabetes: a population-based study Open
Direct Grant for Research from The Chinese University of Hong Kong.
View article: Shortened Relative Leukocyte Telomere Length Is Associated With Polycystic Ovary Syndrome and Metabolic Traits
Shortened Relative Leukocyte Telomere Length Is Associated With Polycystic Ovary Syndrome and Metabolic Traits Open
Background Polycystic ovary syndrome (PCOS) is one of the commonest gyneco‐endocrine disorders amongst women of reproductive age. Whether PCOS and cardiometabolic traits in PCOS patients are associated with shortened telomere length (TL) o…
View article: Proteome‐Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease
Proteome‐Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease Open
Objective To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses. Method We ut…
View article: Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function
Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function Open
INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their…
View article: Type 2 diabetes pathway-specific polygenic risk scores elucidate heterogeneity in clinical presentation, disease progression and diabetic complications in 18,217 Chinese individuals with type 2 diabetes
Type 2 diabetes pathway-specific polygenic risk scores elucidate heterogeneity in clinical presentation, disease progression and diabetic complications in 18,217 Chinese individuals with type 2 diabetes Open
Aims/hypothesis Type 2 diabetes is a complex and heterogeneous disease and the aetiological components underlying the heterogeneity remain unclear in the Chinese and East Asian population. Therefore, we aimed to investigate whether specifi…
View article: Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis
Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis Open
Background Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GD…
View article: Author Correction: Genotype-stratified treatment for monogenic insulin resistance: a systematic review
Author Correction: Genotype-stratified treatment for monogenic insulin resistance: a systematic review Open
Correction to: Communications Medicinehttps://doi.org/10.1038/s43856-023-00368-9, published online 05 October 2023 The file Supplementary Data 3 was missing when this article was published. It has now been added and can be accessed via the…
View article: Precision gestational diabetes treatment: a systematic review and meta-analyses
Precision gestational diabetes treatment: a systematic review and meta-analyses Open
Background Gestational Diabetes Mellitus (GDM) affects approximately 1 in 7 pregnancies globally. It is associated with short- and long-term risks for both mother and baby. Therefore, optimizing treatment to effectively treat the condition…