Chujun Wu
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View article: From OCD Symptoms to Sleep Disorders: The Crucial Role of Vitamin B12
From OCD Symptoms to Sleep Disorders: The Crucial Role of Vitamin B12 Open
Lower levels of vitamin B12 not only affect sleep quality but also partially mediate the impact of OCD symptoms on sleep disturbances. Future clinical attention to vitamin B12 deficiency is crucial for further assessing the relationship be…
View article: Relationship between serum homocysteine, folate and vitamin B12 levels and cognitive function in patients with first-treated obsessive-compulsive disorder
Relationship between serum homocysteine, folate and vitamin B12 levels and cognitive function in patients with first-treated obsessive-compulsive disorder Open
Background The study aimed to investigate the correlation between HCY, vitamin B12, and folate levels and cognitive function in patients with obsessive-compulsive disorder (OCD). Methods Fifty patients with first-treated OCD and 50 matched…
View article: The Mediating Role of Sleep Disturbances in the Relationship Between Obsessive-Compulsive Symptoms and Suicidal Ideation: The Moderating Effect of Childhood Trauma
The Mediating Role of Sleep Disturbances in the Relationship Between Obsessive-Compulsive Symptoms and Suicidal Ideation: The Moderating Effect of Childhood Trauma Open
Objective: This study aims to investigate the relationships and underlying mechanisms among obsessive-compulsive symptoms, sleep disturbances, childhood trauma, and suicidal ideation in patients with obsessive-compulsive disorder (OCD). Me…
View article: Regional brain activity and connectivity associated with childhood trauma in drug-naive patients with obsessive–compulsive disorder
Regional brain activity and connectivity associated with childhood trauma in drug-naive patients with obsessive–compulsive disorder Open
Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive, compulsive behaviors, with childhood trauma recognized as a contributing factor to its pathophysiology. This study aimed to delineate brain function…
View article: Alerting network, cognitive flexibility in children with attention deficit hyperactivity disorder and the moderating effect of neuroticism
Alerting network, cognitive flexibility in children with attention deficit hyperactivity disorder and the moderating effect of neuroticism Open
Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder, and cognitive flexibility is a sub-component of executive functioning. Studies have shown impairments in cognitive flexibility in ADHD, which is af…
View article: Omega-3 Polyunsaturated Fatty Acids Supplementation Alleviate Anxiety Rather Than Depressive Symptoms Among First-Diagnosed, Drug-Naïve Major Depressive Disorder Patients: A Randomized Clinical Trial
Omega-3 Polyunsaturated Fatty Acids Supplementation Alleviate Anxiety Rather Than Depressive Symptoms Among First-Diagnosed, Drug-Naïve Major Depressive Disorder Patients: A Randomized Clinical Trial Open
Background Omega-3 polyunsaturated fatty acids (n-3 PUFAs) augmentation of antidepressants has shown great potential in the prevention and treatment of major depressive disorders (MDD). Objective To investigate the effect of n-3 PUFAs plus…
View article: Global Functional Connectivity Analysis Indicating Dysconnectivity of the Hate Circuit in Major Depressive Disorder
Global Functional Connectivity Analysis Indicating Dysconnectivity of the Hate Circuit in Major Depressive Disorder Open
Background Abnormalities of functional connectivity (FC) in certain brain regions are closely related to the pathophysiology of major depressive disorder (MDD). Findings are inconsistent with different presuppositions in regions of interes…
View article: Altered Fractional Amplitude of Low-Frequency Fluctuation in Major Depressive Disorder and Bipolar Disorder
Altered Fractional Amplitude of Low-Frequency Fluctuation in Major Depressive Disorder and Bipolar Disorder Open
Background: Discriminating between major depressive disorder (MDD) and bipolar disorder (BD) remains challenging and cognitive deficits in MDD and BD are generally recognized. In this study, the fractional amplitude of low-frequency fluctu…
View article: Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder
Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder Open
Default mode network (DMN) plays a key role in the pathophysiology of in bipolar disorder (BD). However, the homogeneity of this network in BD is still poorly understood. This study aimed to investigate abnormalities in the NH of the DMN a…
View article: Low BDNF levels in serum are associated with cognitive impairments in medication-naïve patients with current depressive episode in BD II and MDD
Low BDNF levels in serum are associated with cognitive impairments in medication-naïve patients with current depressive episode in BD II and MDD Open
Our study showed the decreased serum BDNF in MDD and BD II patients, suggesting BDNF may be involved in the pathophysiology of MDD and BD II. BDNF and cognitive deficits are both of low efficiency in distinguishing BD II from MDD. Decrease…
View article: Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder
Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder Open
Objectives. Previous researches have demonstrated that abnormal functional connectivity (FC) is associated with the pathophysiology of bipolar disorder (BD). However, inconsistent results were obtained due to different selections of region…
View article: Cerebral glucose metabolism in bipolar disorder: A voxel‐based meta‐analysis of positron emission tomography studies
Cerebral glucose metabolism in bipolar disorder: A voxel‐based meta‐analysis of positron emission tomography studies Open
Background Previous positron emission tomography studies have reported the changes of cerebral glucose metabolism in bipolar disorder. However, the findings across studies remain controversial, containing differing results. Methods A syste…
View article: Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder
Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder Open
This study further confirms the abnormal brain activities in extensive regions, and these brain regions are primarily located in the fronto-temporal-occipital circuit and the cerebellum vermis of patients with BD. The regional neural activ…
View article: Association Between Bipolar Disorder and Low Bone Mass: A Cross-Sectional Study With Newly Diagnosed, Drug-Naïve Patients
Association Between Bipolar Disorder and Low Bone Mass: A Cross-Sectional Study With Newly Diagnosed, Drug-Naïve Patients Open
www.chictr.org.cn, identifier ChiCTR190002137.
View article: Human papillomavirus infection increases the risk of breast carcinoma: a large-scale systemic review and meta-analysis of case-control studies
Human papillomavirus infection increases the risk of breast carcinoma: a large-scale systemic review and meta-analysis of case-control studies Open
This systemic review and meta-analysis provide the evidence for HPV infection as a potential risk factor in BC, while the mechanism of this hypothesis still needs further evaluation.
View article: A Novel Missense Mutation of the DDHD1 Gene Associated with Juvenile Amyotrophic Lateral Sclerosis
A Novel Missense Mutation of the DDHD1 Gene Associated with Juvenile Amyotrophic Lateral Sclerosis Open
Background: Juvenile amyotrophic lateral sclerosis (jALS) is a rare form of ALS with an onset age of less than 25 years and is frequently thought to be genetic in origin. DDHD1 gene mutations have been reported to be associated with the SP…