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View article: Supplementary Figure 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 3 shows the effect of ISR pathway activation on dendritic cells and T cells.
View article: Supplementary Table 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 2 shows the primers used in this study.
View article: Data from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Data from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this s…
View article: Supplementary Table 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 4 shows the clinicopathological characteristics of surgically resected primary NSCLC patients included in this study.
View article: Supplementary Figure 6 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 6 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 6 shows the characterization of CD155 expression in surgically resected primary NSCLC patients.
View article: Supplementary Figure 5 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 5 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 5 shows the effect of ISR pathway inhibition on immune cell populations in vivo.
View article: Supplementary Figure 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 2 shows the effect of ISR pathway activation on protein and mRNA stability, and translation.
View article: Supplementary Table 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 1 shows the chemicals used in this study.
View article: Supplementary Figure 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 4 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 4 shows the effect of ISR pathway inhibition in vitro and in vivo.
View article: Supplementary Figure 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Figure 1 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Figure 1 shows the effect of ISR pathway activation on multiple immune checkpoint proteins
View article: Supplementary Table 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
Supplementary Table 3 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
Supplementary Table 3 shows the antibodies used in this study.
View article: The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer Open
The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this s…
View article: Data from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Data from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Peripheral nerves promote mouse bone marrow regeneration by activating β2- and β3-adrenergic receptor signaling, raising the possibility that nonselective β-blockers could inhibit engraftment after hematopoietic cell transplants (HCT). We …
View article: Supplementary Figure 6 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Figure 6 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Figure S6: Clinical variables associated with time to hematopoietic regeneration after autologous transplantation in Vanderbilt patients.
View article: Supplementary Figure 10 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Figure 10 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Figure S10: Post-transplant chemotherapy or use of non-selective b blockers was not associated with changes in neutrophil engraftment after allogeneic transplantation in Vanderbilt allogeneic HCT patients.
View article: Supplementary Table 3 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Table 3 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Table S3. Characteristics of Vanderbilt autologous transplant patients. Continuous measures are shown as mean (SD), and categorical measures as percentages. A one-way ANOVA was used to compare continuous variables, and a χ2 t…
View article: Supplementary Figure 5 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Figure 5 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Figure S5: Clinical variables associated with time to hematopoietic regeneration after allogeneic transplantation at UTSW.
View article: Supplementary Figure 4 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Figure 4 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Figure S4: Clinical variables associated with time to hematopoietic regeneration after autologous transplantation at UTSW.
View article: Supplementary Figure 11 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Figure 11 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Figure S11: Infection, graft-versus-host disease, and causes of death in UTSW allogeneic HCT recipients.
View article: Supplementary Table 6 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Table 6 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Table S6. Related to Fig. 1-7. Key Resources Table.
View article: Supplementary Table 1 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Table 1 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Table S1. Characteristics of UTSW autologous transplant patients. Continuous measures are shown as mean (SD) and categorical measures as percentages. A one-way ANOVA was used to compare continuous variables, and a χ2 test was…
View article: Supplementary Figure 3 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Figure 3 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Figure S3: Propensity matched analysis of the effect of non-selective b adrenergic receptor inhibitors on hematopoietic regeneration in Vanderbilt patients undergoing autologous and allogeneic transplantation.
View article: Supplementary Figure 9 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Figure 9 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Figure S9: The inhibitory effect of carvedilol on hematopoietic regeneration after syngeneic transplantation can be overcome by transplanting larger doses of bone marrow cells.
View article: Supplementary Table 2 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Table 2 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Table S2. Characteristics of UTSW allogeneic transplant patients. Abbreviations: Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), mixed-pheno…
View article: Supplementary Table 5 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Supplementary Table 5 from Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants Open
Supplementary Table S5. Related to Fig. 1-4 and Supplementary Fig. S3. Cell populations analyzed by flow cytometry in this study.