Chul Ju Han
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View article: Long-Term Outcome of a Multicenter Prospective Study on Efficacy and Safety of High-Dose Stereotactic Body Radiation Therapy ≥48-h Interfraction Interval for ≤5 cm Hepatocellular Carcinoma
Long-Term Outcome of a Multicenter Prospective Study on Efficacy and Safety of High-Dose Stereotactic Body Radiation Therapy ≥48-h Interfraction Interval for ≤5 cm Hepatocellular Carcinoma Open
Introduction: The goal of this study was to evaluate the efficacy and safety of high-dose stereotactic body radiation therapy (SBRT) with an extended (48 h or more) interfraction interval for hepatocellular carcinoma (HCC) ≤5 cm in size af…
View article: Author Correction: Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status
Author Correction: Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status Open
View article: Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status
Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status Open
Hepatocellular carcinoma (HCC) is characterized by high incidence and fatality rates worldwide. In our exploration of prognostic factors in HCC, the 26s proteasome subunit, non-ATPase 1 (PSMD1) protein emerged as a significant contributor,…
View article: VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic Telangiectasia
VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic Telangiectasia Open
Brain arteriovenous malformations (BAVMs) are a critical concern in hereditary hemorrhagic telangiectasia (HHT) patients, carrying the risk of life-threatening intracranial hemorrhage. While traditionally seen as congenital, the debate con…
View article: VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic Telangiectasia
VEGFR2 Expression Correlates with Postnatal Development of Brain Arteriovenous Malformations in a Mouse Model of Type I Hereditary Hemorrhagic Telangiectasia Open
Brain arteriovenous malformations (BAVMs) are a critical concern in hereditary hemorrhagic telangiectasia (HHT) patients, carrying the risk of life-threatening intracranial hemorrhage. While traditionally seen as congenital, the debate con…
View article: Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia
Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia Open
View article: NPFFR2 Contributes to the Malignancy of Hepatocellular Carcinoma Development by Activating RhoA/YAP Signaling
NPFFR2 Contributes to the Malignancy of Hepatocellular Carcinoma Development by Activating RhoA/YAP Signaling Open
G protein–coupled receptors (GPCRs) are a diverse family of cell surface receptors implicated in various physiological functions, making them common targets for approved drugs. Many GPCRs are abnormally activated in cancers and have emerge…
View article: Background frequency can enhance the prognostication power of EEG patterns categories in comatose cardiac arrest survivors: a prospective, multicenter, observational cohort study
Background frequency can enhance the prognostication power of EEG patterns categories in comatose cardiac arrest survivors: a prospective, multicenter, observational cohort study Open
Background We assessed the prognostic accuracy of the standardized electroencephalography (EEG) patterns (“highly malignant,” “malignant,” and “benign”) according to the EEG timing (early vs. late) and investigated the EEG features to enha…
View article: Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan
Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan Open
View article: Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice
Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice Open
View article: Recent Advances in Basic Research for Brain Arteriovenous Malformation
Recent Advances in Basic Research for Brain Arteriovenous Malformation Open
Arteriovenous malformations (AVMs) are abnormal connections of vessels that shunt blood directly from arteries into veins. Rupture of brain AVMs (bAVMs) can cause life-threatening intracranial bleeding. Even though the majority of bAVM cas…
View article: GSTA4 mediates reduction of cisplatin ototoxicity in female mice
GSTA4 mediates reduction of cisplatin ototoxicity in female mice Open
View article: TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma and its depletion impairs invasion activity
TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma and its depletion impairs invasion activity Open
Transmembrane protein 165 (TMEM165), a Golgi protein, functions in ion homeostasis and vesicular trafficking in the Golgi apparatus. While mutations in TMEM165 are known to cause human 'congenital disorders of glycosylation', a recessive a…
View article: Protein arginine methyltransferase 5 is implicated in the aggressiveness of human hepatocellular carcinoma and controls the invasive activity of cancer cells
Protein arginine methyltransferase 5 is implicated in the aggressiveness of human hepatocellular carcinoma and controls the invasive activity of cancer cells Open
Protein arginine methyltransferase 5 (PRMT5) is a protein that catalyzes transfer of methyl groups to the arginine residues of proteins and is involved in diverse cellular and biological responses. While the participation of PRMT5 in cance…
View article: Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice
Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice Open
Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP + to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from o…
View article: Correction: Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Correction: Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance Open
View article: GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR
GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR Open
Glutathione reductase (GSR), a key member of the glutathione antioxidant defense system, converts oxidized glutathione (GSSG) to reduced glutathione (GSH) and maintains the intracellular glutathione redox state to protect the cells from ox…
View article: <i>G6pd</i> Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea
<i>G6pd</i> Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea Open
Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be th…
View article: The mitochondrial hinge protein, <scp>UQCRH</scp>, is a novel prognostic factor for hepatocellular carcinoma
The mitochondrial hinge protein, <span>UQCRH</span>, is a novel prognostic factor for hepatocellular carcinoma Open
Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol–cytochrome c reductase hinge protein ( UQCRH ) consists of…
View article: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance Open
View article: Association between metformin use and mortality in patients with type 2 diabetes mellitus and localized resectable pancreatic cancer: a nationwide population-based study in korea
Association between metformin use and mortality in patients with type 2 diabetes mellitus and localized resectable pancreatic cancer: a nationwide population-based study in korea Open
This large study indicates that metformin might decrease cancer-specific mortality rates in localized resectable pancreatic cancer patients with pre-existing diabetes, independently of other factors, with a dose-response relationship.
View article: Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice
Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice Open
Regular physical exercise reduces the risk for obesity, cardiovascular diseases, and disability and is associated with longer lifespan expectancy (Taylor et al., 2004; Pahor et al., 2014; Anton et al., 2015; Arem et al., 2015). In contrast…
View article: Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study
Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study Open
View article: Radiofrequency ablation versus stereotactic body radiotherapy for small hepatocellular carcinoma: a Markov model‐based analysis
Radiofrequency ablation versus stereotactic body radiotherapy for small hepatocellular carcinoma: a Markov model‐based analysis Open
The aim of this study is to compare radiofrequency ablation ( RFA ) with stereotactic body radiotherapy ( SBRT ) for hepatocellular carcinomas ( HCC ) smaller than 3 cm. A Markov cohort model was developed to simulate a cohort of patients …
View article: GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus
GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus Open
Gap detection or gap pre-pulse inhibition of the acoustic startle (GPIAS) has been successfully used in rat and guinea pig models of tinnitus, yet this system has been proven to have low efficacy in CBA mice, with low basal GPIAS and subtl…
View article: Association of Metformin Use With Cancer-Specific Mortality in Hepatocellular Carcinoma After Curative Resection
Association of Metformin Use With Cancer-Specific Mortality in Hepatocellular Carcinoma After Curative Resection Open
Many preclinical reports and retrospective population studies have shown an anticancer effect of metformin in patients with several types of cancer and comorbid type 2 diabetes mellitus (T2DM). In this work, the anticancer effect of metfor…
View article: Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice Open
View article: Benefits of stereotactic ablative radiotherapy combined with incomplete transcatheter arterial chemoembolization in hepatocellular carcinoma
Benefits of stereotactic ablative radiotherapy combined with incomplete transcatheter arterial chemoembolization in hepatocellular carcinoma Open
View article: PROGRESS REPORT ON THE ROLES OF MITOCHONDRIAL THIOREDOXIN IN AGE-RELATED HEARING LOSS IN MICE
PROGRESS REPORT ON THE ROLES OF MITOCHONDRIAL THIOREDOXIN IN AGE-RELATED HEARING LOSS IN MICE Open
CpG site showed borderline significant association to CTP.These findings suggest association between FOXO3A and bone status.The associations could, a least in part, have a genetic basis (cf. the analysis of twins as single individuals) or …
View article: ASSOCIATIONS OF FOXO3A AND EXTREME LONGEVITY IN THE LLFS, NECS, AND AJCS
ASSOCIATIONS OF FOXO3A AND EXTREME LONGEVITY IN THE LLFS, NECS, AND AJCS Open
Age-related hearing loss (AHL) is the third most common chronic condition among the elderly; however, there are no treatments or preventative interventions for this irreversible sensory disorder.Mitochondrial isocitrate dehydrogenase 2 (ID…