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View article: Leveraging artificial intelligence in antibody-drug conjugate development: from target identification to clinical translation in oncology
Leveraging artificial intelligence in antibody-drug conjugate development: from target identification to clinical translation in oncology Open
Artificial intelligence (AI) is opening new frontiers in the development of antibody-drug conjugates (ADCs), offering unprecedented opportunities for precision therapy. This review outlines how AI empowers each stage of the ADC pipeline. I…
View article: Surgical outcomes of smoking and nonsmoking women with lung adenocarcinoma
Surgical outcomes of smoking and nonsmoking women with lung adenocarcinoma Open
Our results suggest that women with a history of tobacco use present with significantly more preoperative comorbidities and postoperative complications than women without a smoking history. Subset analysis revealed that the only postoperat…
View article: Spatio-temporal mass spectrometry in living cells reveals regulators of cuproptosis
Spatio-temporal mass spectrometry in living cells reveals regulators of cuproptosis Open
Cuproptosis is a unique form of regulated cell death triggered by excessive copper accumulation in mitochondria. To decipher the mechanisms of cuproptosis, we develop Spatio-Temporal Mass Spectrometry (STMS) technique to characterize dynam…
View article: Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate
Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate Open
Pyroptosis is a proinflammatory programmed cell death (PCD) that is causally linked to antitumor immune responses, but the therapeutic potential of pyroptosis has been limited by the lack of tumor‐specific and controllable inducers. Here, …
View article: A Rare Case of Primary Pulmonary Meningioma
A Rare Case of Primary Pulmonary Meningioma Open
Background: Primary pulmonary meningioma (PPM) is an uncommon tumor originating in the lung. Although predominantly benign, there are instances of aggressive tumors exhibiting malignant features. Due to their rarity, our understanding of P…
View article: M4: Multi-proxy multi-gate mixture of experts network for multiple instance learning in histopathology image analysis
M4: Multi-proxy multi-gate mixture of experts network for multiple instance learning in histopathology image analysis Open
Multiple instance learning (MIL) has been successfully applied for whole slide images (WSIs) analysis in computational pathology, enabling a wide range of prediction tasks from tumor subtyping to inferring genetic mutations and multi-omics…
View article: DIA-TSK: A Dynamic Incremental Adaptive Takagi–Sugeno–Kang Fuzzy Classifier
DIA-TSK: A Dynamic Incremental Adaptive Takagi–Sugeno–Kang Fuzzy Classifier Open
In order to continuously adapt to dynamic data distributions, existing incremental and online learning methods adopt bagging or boosting structures, in which some sub-classifiers are abandoned when the data distribution varies significantl…
View article: EGFR-Targeted Therapies: A Literature Review
EGFR-Targeted Therapies: A Literature Review Open
Lung cancer remains the leading cause of cancer death in the United States, underscoring the critical need to optimize treatment strategies. Compared to conventional treatments such as surgical resection, radiotherapy, chemotherapy, and im…
View article: Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions
Blocker-SELEX: a structure-guided strategy for developing inhibitory aptamers disrupting undruggable transcription factor interactions Open
Despite the well-established significance of transcription factors (TFs) in pathogenesis, their utilization as pharmacological targets has been limited by the inherent challenges in modulating their protein interactions. The lack of define…
View article: DrugMetric: quantitative drug-likeness scoring based on chemical space distance
DrugMetric: quantitative drug-likeness scoring based on chemical space distance Open
The process of drug discovery is widely known to be lengthy and resource-intensive. Artificial Intelligence approaches bring hope for accelerating the identification of molecules with the necessary properties for drug development. Drug-lik…
View article: Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions
Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions Open
Summary Despite the well-established significance of transcription factors (TFs) in pathogenesis, their utilization as pharmacological targets has been limited by the inherent challenges associated with modulating their protein-protein and…
View article: Multimodal Diverse Granularity Fusion Network based on US and CT Images for Lymph Node Metastasis Prediction of Thyroid Carcinoma
Multimodal Diverse Granularity Fusion Network based on US and CT Images for Lymph Node Metastasis Prediction of Thyroid Carcinoma Open
Accurately predicting the risk of cervical lymph node metastasis (LNM) is crucial for surgical decision-making in thyroid cancer patients, and the difficulty in it often leads to over-treatment. Ultrasound (US) and computed tomography (CT)…
View article: BatmanNet: bi-branch masked graph transformer autoencoder for molecular representation
BatmanNet: bi-branch masked graph transformer autoencoder for molecular representation Open
Although substantial efforts have been made using graph neural networks (GNNs) for artificial intelligence (AI)-driven drug discovery, effective molecular representation learning remains an open challenge, especially in the case of insuffi…
View article: Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody-Drug Conjugates in Preclinical Models
Therapeutic Targeting Tongue Squamous Cell Carcinoma via ICAM1 Antibody-Drug Conjugates in Preclinical Models Open
To date, the treatment options for metastatic and recurrent tongue squamous cell carcinoma (TSCC) remain limited due to the lack of effective drug targets and therapeutics. Here we report the identification of ICAM1 as a TSCC target candid…
View article: Differential Efficacy From the Addition of Bortezomib to R-CHOP in Diffuse Large B-Cell Lymphoma According to the Molecular Subgroup in the REMoDL-B Study With a 5-Year Follow-Up
Differential Efficacy From the Addition of Bortezomib to R-CHOP in Diffuse Large B-Cell Lymphoma According to the Molecular Subgroup in the REMoDL-B Study With a 5-Year Follow-Up Open
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. …
View article: Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma Open
Despite the effectiveness of immuno-chemotherapy, 40% of patients with diffuse large B-cell lymphoma (DLBCL) experience relapse or refractory disease. Longitudinal studies have previously focused on the mutational landscape of relapse but …
View article: Resolving heterogeneity in Diffuse Large B-cell Lymphoma using a comprehensive modular expression map
Resolving heterogeneity in Diffuse Large B-cell Lymphoma using a comprehensive modular expression map Open
Diffuse large B-cell lymphoma (DLBCL) is characterised by pronounced genetic and biological heterogeneity. Several partially overlapping classification systems exist – developed from mutation, rearrangement or gene expression data. We appl…
View article: Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit
Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit Open
Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), which was enriched for MYC / BC…
View article: Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy
Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy Open
Purpose Biologic heterogeneity is a feature of diffuse large B-cell lymphoma (DLBCL), and the existence of a subgroup with poor prognosis and phenotypic proximity to Burkitt lymphoma is well known. Conventional cytogenetics identifies some…
View article: Cell‐of‐origin in diffuse large B‐cell lymphoma: findings from the <scp>UK</scp>'s population‐based Haematological Malignancy Research Network
Cell‐of‐origin in diffuse large B‐cell lymphoma: findings from the <span>UK</span>'s population‐based Haematological Malignancy Research Network Open
Diffuse large B-cell lymphoma (DLBCL) is the commonest haematological malignancy, accounting for approximately half of all aggressive B-cell lymphomas. Around 80% of patients present with DLBCL not otherwise specified (NOS), which, althoug…
View article: A category‐free approach to prognostic modelling in aggressive non‐<scp>H</scp>odgkin <scp>B</scp> cell lymphomas based on large patient databases
A category‐free approach to prognostic modelling in aggressive non‐<span>H</span>odgkin <span>B</span> cell lymphomas based on large patient databases Open
Introduction: Aggressive non-Hodgkin B cell lymphomas are a heterogeneous group that is usually divided into established categories, such as Burkitt lymphoma and subtypes of diffuse large B cell lymphoma. Advances in genomic profiling have…
View article: <scp>Pan</scp>‐lymphoma classification
<span>Pan</span>‐lymphoma classification Open
Introduction: Cell of origin classification of diffuse large B-cell lymphoma (DL-BCL) using gene expression signatures identifies patients with distinct molecular features and survival outcomes. Whilst the identification of activated B-cel…
View article: GENE EXPRESSION PROFILING AND MUTATION ANALYSIS CAN AID TREATMENT DECISION MAKING IN AGGRESSIVE <scp>B</scp> CELL LYMPHOMA PATIENTS
GENE EXPRESSION PROFILING AND MUTATION ANALYSIS CAN AID TREATMENT DECISION MAKING IN AGGRESSIVE <span>B</span> CELL LYMPHOMA PATIENTS Open
Introduction: Accurate distinction between diffuse large B-cell lymphoma (DLBL) and Burkitt lymphoma is critical as both require very different treatments. For those with features between DLBL and Burkitt, the treatment choice is unclear. …
View article: DIFFERENTIAL EFFICACY OF BORTEZOMIB IN SUBTYPES OF DIFFUSE LARGE B‐CELL LYMPHOMA (DLBL): a PROSPECTIVE RANDOMISED STUDY STRATIFIED BY TRANSCRIPTOME PROFILING: REMODL‐B
DIFFERENTIAL EFFICACY OF BORTEZOMIB IN SUBTYPES OF DIFFUSE LARGE B‐CELL LYMPHOMA (DLBL): a PROSPECTIVE RANDOMISED STUDY STRATIFIED BY TRANSCRIPTOME PROFILING: REMODL‐B Open
DLBL subtypes identified by patterns of gene expression correspond to germinal center (GCB) or activated (ABC) B‐cells like. The latter demonstrate dysregulation of the NF‐KB pathway. Outcomes of treatment with R‐CHOP are inferior for ABC …