Chun‐Jen Liu
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View article: Elebsiran and PEG-IFNα for chronic hepatitis B infection: a partially randomized, open-label, phase 2 trial
Elebsiran and PEG-IFNα for chronic hepatitis B infection: a partially randomized, open-label, phase 2 trial Open
Functional cure is a goal for the treatment of chronic hepatitis B virus (HBV) infection; however, it is infrequently achieved with currently approved treatments. Here we provide a randomized evaluation of the small interfering RNA elebsir…
View article: Serum Mac-2 Binding Protein Glycosylation Isomer in Predicting Hepatocellular Carcinoma Occurrence among Patients with Direct-Acting Antiviral-induced HCV Cure
Serum Mac-2 Binding Protein Glycosylation Isomer in Predicting Hepatocellular Carcinoma Occurrence among Patients with Direct-Acting Antiviral-induced HCV Cure Open
Mac-2-binding protein glycosylation isomer (M2BPGi), a promising biomarker for predicting hepatocellular carcinoma (HCC), was evaluated in predicting HCC occurrence after hepatitis C virus (HCV) cure with direct-acting antivirals (DAAs). 7…
View article: A multinational survey of physician knowledge about management of chronic hepatitis C
A multinational survey of physician knowledge about management of chronic hepatitis C Open
The surveyed physicians demonstrated a strong awareness of the current HCV guidelines but indicated potential gaps in knowledge and inconsistencies. Continuous education and support are essential to enhance adherence to HCV management prot…
View article: Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor
Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor Open
Essential tremor (ET) is a common neurological disease that is characterized by 4–12 Hz kinetic tremors of the upper limbs and high genetic heterogeneity. Although numerous candidate genes and loci have been reported, the etiology of ET re…
View article: Effects of Exercise Intervention in Subjects with Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Exercise Intervention in Subjects with Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disorder globally, including in Asia-Pacific countries. In addition to contributing to severe liver disorders, MASLD increases the risk of various compli…
View article: Impact of tenofovir vs. entecavir treatment on progression of chronic hepatitis B: A nationwide cohort study
Impact of tenofovir vs. entecavir treatment on progression of chronic hepatitis B: A nationwide cohort study Open
The comparative effectiveness of tenofovir vs. entecavir treatment in preventing hepatocellular carcinoma (HCC) for patients with chronic hepatitis B (CHB) remains controversial. Using a nationwide cohort study involving 55,885 pati…
View article: Switching to tenofovir alafenamide in virally-suppressed chronic hepatitis B patients with renal/hepatic impairment: Phase 2 study sub-analysis from Taiwan
Switching to tenofovir alafenamide in virally-suppressed chronic hepatitis B patients with renal/hepatic impairment: Phase 2 study sub-analysis from Taiwan Open
NCT03180619/GS-US-320-4035.
View article: Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan
Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan Open
This study examines the impact of hepatitis C virus (HCV) eradication through sofosbuvir/velpatasvir (SOF/VEL) treatment on glycated hemoglobin (HbA1c) levels in patients with chronic hepatitis C and type 2 diabetes mellitus (T2DM). Utiliz…
View article: Long-term risk of depression and the impact of risk factors among chronic hepatitis C patients after successful antiviral therapy: A nationwide real-world Taiwanese cohort (T-COACH)
Long-term risk of depression and the impact of risk factors among chronic hepatitis C patients after successful antiviral therapy: A nationwide real-world Taiwanese cohort (T-COACH) Open
Our findings highlight the need for long-term psychiatric monitoring in patients with HCV infection after treatment, particularly in high-risk subgroups. Further studies involving direct-acting antiviral-treated cohorts with extended follo…
View article: Impact of Hepatitis C Virus Clearance on Cardiovascular Risk: A Real‐World Experience From the Nationwide Taiwan Hepatitis C Virus Registry
Impact of Hepatitis C Virus Clearance on Cardiovascular Risk: A Real‐World Experience From the Nationwide Taiwan Hepatitis C Virus Registry Open
Hepatitis C virus (HCV) infection is associated with an increased risk of cardiovascular disease (CVD); however, the impact of interferon (IFN)‐based therapy on cardiovascular outcomes remains unclear. This nationwide cohort study included…
View article: Kommerell diverticulum with aberrant left subclavian artery: pathological process or natural growth?
Kommerell diverticulum with aberrant left subclavian artery: pathological process or natural growth? Open
Background Kommerell diverticulum (KD) is a rare congenital abnormality of aortic arch. The indication for surgery in asymptomatic patients has been controversial due to the paucity of knowledge regarding the natural evolvement of KD. Meth…
View article: Sequential combination with ropeginterferon alfa-2b and anti-PD-1 treatment as adjuvant therapy in HBV-related HCC: a phase 1 dose escalation trial
Sequential combination with ropeginterferon alfa-2b and anti-PD-1 treatment as adjuvant therapy in HBV-related HCC: a phase 1 dose escalation trial Open
Background/purpose Post-operative recurrence is a major clinical challenge with hepatocellular carcinoma (HCC). While currently unapproved, anti-programmed cell death 1 (PD-1) and anti-vascular endothelial growth factor combination adjuvan…
View article: Evolution of qHBsAg levels in HBV/HCV co-infected patients with low serum HBV DNA: Comparison between treated versus untreated
Evolution of qHBsAg levels in HBV/HCV co-infected patients with low serum HBV DNA: Comparison between treated versus untreated Open
In HBV/HCV co-infected patients with low serum HBV DNA, favorable HBsAg dynamics was found post-interferon/ribavirin therapy. These findings supported further investigations of interferon-based therapy in this clinical setting.
View article: Automated Whole-Liver Fat Quantification with Magnetic Resonance Imaging-Derived Proton Density Fat Fraction Map: A Prospective Study in Taiwan
Automated Whole-Liver Fat Quantification with Magnetic Resonance Imaging-Derived Proton Density Fat Fraction Map: A Prospective Study in Taiwan Open
Automated whole-liver fat quantification might be feasible for clinical trials and practice, yielding values with high correlations and concordance with the time-consuming manual measurements from the PDFF map and the values from the highl…
View article: The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease
The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease Open
View article: IgG4-associated autoimmune hepatitis in a 70-year-old woman with progressive liver failure: First case report in Taiwan
IgG4-associated autoimmune hepatitis in a 70-year-old woman with progressive liver failure: First case report in Taiwan Open
View article: Response to comment on “Addition of neutrophil-to-lymphocyte ratio to Pre-DAA FIB-4 does not increase prediction value for de novo liver complications in hepatitis C”
Response to comment on “Addition of neutrophil-to-lymphocyte ratio to Pre-DAA FIB-4 does not increase prediction value for de novo liver complications in hepatitis C” Open
View article: Direct-acting antiviral therapy for patients with hepatitis C virus-related hepatocellular carcinoma: A nationwide cohort study
Direct-acting antiviral therapy for patients with hepatitis C virus-related hepatocellular carcinoma: A nationwide cohort study Open
Background/Aims: The survival benefit of direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection in patients with hepatocellular carcinoma (HCC), particularly in Barcelona Clinic Liver Cancer (BCLC) stages B/C, remains …
View article: High-normal and abnormal alanine transaminase levels linked to increased risk of hepatoma following treatment for chronic hepatitis C
High-normal and abnormal alanine transaminase levels linked to increased risk of hepatoma following treatment for chronic hepatitis C Open
Patients with CHC with high-normal and abnormal posttreatment ALT levels have an increased risk of HCC; thus, HCC surveillance is still necessary in this population.
View article: Posttreatment FIB-4 score change predicts hepatocellular carcinoma in chronic hepatitis C patients: Findings from the Taiwan hepatitis C registry program
Posttreatment FIB-4 score change predicts hepatocellular carcinoma in chronic hepatitis C patients: Findings from the Taiwan hepatitis C registry program Open
Posttreatment FIB-4 score and its change from baseline can be used to stratify HCC risk in patients with CHC receiving DAAs.
View article: Real‐world efficacy and safety of universal 8‐week glecaprevir/pibrentasvir in patients with chronic hepatitis C with early chronic kidney disease or pre‐end‐stage renal disease: Insights from a nationwide hepatisis <scp>C virus</scp> registry in Taiwan
Real‐world efficacy and safety of universal 8‐week glecaprevir/pibrentasvir in patients with chronic hepatitis C with early chronic kidney disease or pre‐end‐stage renal disease: Insights from a nationwide hepatisis <span>C virus</span> registry in Taiwan Open
An 8‐week regimen of glecaprevir/pibrentasvir is recommended for treatment‐naïve patients with chronic hepatitis C (CHC). In alignment with the Taiwanese government's objective to eliminate hepatitis C by 2025, this study aimed to provide …
View article: Long-term serum ferritin dynamics in patients receiving antiviral treatment for hepatitis C virus infection
Long-term serum ferritin dynamics in patients receiving antiviral treatment for hepatitis C virus infection Open
Patients achieving SVR12, irrespective of types of treatment, exhibited more favorable long-term ferritin dynamics compared to those not achieving SVR12. Absence of MASLD may help improve long-term ferritin dynamics a…
View article: Optimization of Limnfepo4 Cathode Materials Via Dual Metal Coating: A Comparative Study of Copper and Nickel Surface Modification
Optimization of Limnfepo4 Cathode Materials Via Dual Metal Coating: A Comparative Study of Copper and Nickel Surface Modification Open
View article: Addition of neutrophil-to-lymphocyte ratio to Pre-DAA FIB-4 does not increase prediction value for de novo liver complications in hepatitis C
Addition of neutrophil-to-lymphocyte ratio to Pre-DAA FIB-4 does not increase prediction value for de novo liver complications in hepatitis C Open
The overall incidence of de novo liver complications after SVR is low during short-term follow-up. Elevated pre-DAA FIB-4 is associated with de novo liver complications after SVR, whereas the addition of pre-DAA NLR does not increase the p…
View article: Clinical care guidance in patients with diabetes and metabolic dysfunction–associated steatotic liver disease: A joint consensus
Clinical care guidance in patients with diabetes and metabolic dysfunction–associated steatotic liver disease: A joint consensus Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, affecting >30% of the global population. Metabolic dysregulation, particularly insulin resistance and its subsequent ma…
View article: Intermanufacturer assessment of diagnostic performance of angiogenic ratio <i>vs</i> glycosylated fibronectin in women with suspected pre‐eclampsia
Intermanufacturer assessment of diagnostic performance of angiogenic ratio <i>vs</i> glycosylated fibronectin in women with suspected pre‐eclampsia Open
Objective To compare the diagnostic performance of different manufacturers' immunoassays for the soluble fms‐like tyrosine kinase‐1 (sFlt‐1)‐to‐placental growth factor (PlGF) ratio with that of a point‐of‐care (PoC) test for glycosylated f…
View article: Impact of HCV eradication by directly acting antivirals on glycemic indices in chronic hepatitis C patients -a nationwide Taiwan HCV registry
Impact of HCV eradication by directly acting antivirals on glycemic indices in chronic hepatitis C patients -a nationwide Taiwan HCV registry Open
The HbA1c levels improved shortly after HCV eradication using GLE/PIB. The improvement in glycemic control can be generalized to all subpopulations, particularly in patients with a higher baseline HbA1c level or diabetes.
View article: Factors associated with pre-treatment hyperferritinemia in patients with chronic hepatitis C virus infection
Factors associated with pre-treatment hyperferritinemia in patients with chronic hepatitis C virus infection Open
View article: Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice
Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice Open
This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary suppleme…
View article: Higher hepatitis B core-specific T cell response is associated with a lower risk of clinical relapse after discontinuation of oral antiviral treatment
Higher hepatitis B core-specific T cell response is associated with a lower risk of clinical relapse after discontinuation of oral antiviral treatment Open
A higher HBc-specific T cell response at EOT was associated with lower risk of clinical relapse and reduced surge of HBV DNA and HBcrAg levels off NA therapy.