Chunxiao Xu
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View article: Research Progress on the Regulation and Developmental Utilization of Bioactive Metabolites Synthesis in Floccularia luteovirens
Research Progress on the Regulation and Developmental Utilization of Bioactive Metabolites Synthesis in Floccularia luteovirens Open
Floccularia luteovirens is a rare edible and medicinal fungus endemic to the Qinghai–Tibet Plateau, prized for its abundance of high-value bioactive metabolites such as polysaccharides, terpenoids, and ergothioneine, which exhibit a variet…
View article: Correlations between streamwise velocity and temperature fluctuations in compressible turbulent channel flows from the perspective of coherent structures
Correlations between streamwise velocity and temperature fluctuations in compressible turbulent channel flows from the perspective of coherent structures Open
In this work, the correlations between streamwise velocity and temperature fluctuations are investigated in compressible turbulent channel flows from the perspective of coherent structures. The intense fluctuation structures and quadrant-e…
View article: Mean velocity profiles and total shear stress profiles in adverse-pressure-gradient turbulent boundary layers considering history effect
Mean velocity profiles and total shear stress profiles in adverse-pressure-gradient turbulent boundary layers considering history effect Open
This study focuses on developing a predictive model for mean velocity profiles and total shear stress profiles in turbulent boundary layers subjected to adverse pressure gradients, especially with history effects. A new scaling using frict…
View article: Taming interleukin‐12: Engineering of bispecific antibody‐based <scp>IL</scp>‐12 mimetics with biased agonism capacities
Taming interleukin‐12: Engineering of bispecific antibody‐based <span>IL</span>‐12 mimetics with biased agonism capacities Open
In this work, we have generated bispecific interleukin (IL)‐12 surrogate agonists based on camelid‐derived single‐domain antibodies (sdAbs) targeting the IL‐12 receptor (IL‐12R) subunits IL‐12Rβ1 and IL‐12Rβ2. Following immunization and an…
View article: Baroclinic Vorticity Generation Near the Turbulent/Non-turbulent Interface of a Boundary Layer with Combustion
Baroclinic Vorticity Generation Near the Turbulent/Non-turbulent Interface of a Boundary Layer with Combustion Open
Enstrophy transport is examined in a recent direct numerical simulation database of compressible turbulent boundary layer featuring non-premixed hydrogen-air combustion. The inlet flow profile combines a cold, sonic hydrogen stream near th…
View article: Prolate spheroids settling in a quiescent fluid: clustering, microstructures and collisions
Prolate spheroids settling in a quiescent fluid: clustering, microstructures and collisions Open
In this study we investigate the sedimentation of prolate spheroids in a quiescent fluid by means of the particle-resolved direct numerical simulation. With the increase of the particle volume fraction $\phi$ from $0.1\,\%$ to $10\,\%$ , w…
View article: A total-shear-stress-conserved wall model for large-eddy simulation of high-Reynolds number wall turbulence
A total-shear-stress-conserved wall model for large-eddy simulation of high-Reynolds number wall turbulence Open
Wall-modeled large-eddy simulation (WMLES) is widely recognized as a useful method for simulation of turbulent flows at high Reynolds numbers. Nevertheless, a continual issue in different wall models is the shift of the mean velocity profi…
View article: Onset of global instability in a premixed annular V-flame
Onset of global instability in a premixed annular V-flame Open
We investigate self-excited axisymmetric oscillations of a lean premixed methane–air V-flame in a laminar annular jet. The flame is anchored near the rim of the centrebody, forming an inverted cone, while the strongest vorticity is concent…
View article: Direct numerical simulation of a supersonic turbulent boundary layer with hydrogen combustion
Direct numerical simulation of a supersonic turbulent boundary layer with hydrogen combustion Open
The complex behaviours of supersonic turbulent boundary-layer flows interacting with combustion is explored through the use of direct numerical simulations. The chosen flow model is a non-premixed hydrogen–air flame ignited within a three-…
View article: Interactions between the near-wall turbulent structures and heavy particles in compressible turbulent boundary layers
Interactions between the near-wall turbulent structures and heavy particles in compressible turbulent boundary layers Open
In the present study, we conduct direct numerical simulations to investigate the near-wall dynamics of compressible turbulent boundary layers at the free-stream Mach number of 6 laden with heavy particles. By inspecting the instantaneous n…
View article: Oscillation migration of a neutrally buoyant oblate spheroid in the elasto-inertial duct flow
Oscillation migration of a neutrally buoyant oblate spheroid in the elasto-inertial duct flow Open
The peculiar migration and rotational dynamics of non-spherical particles in non-Newtonian flows stem from the interplay between fluid rheology and fluid inertial effects. In this paper, the cross-flow migration of a neutrally buoyant obla…
View article: The effect of hyperuricemia and its interaction with hypertension towards chronic kidney disease in patients with type 2 diabetes: evidence from a cross- sectional study in Eastern China
The effect of hyperuricemia and its interaction with hypertension towards chronic kidney disease in patients with type 2 diabetes: evidence from a cross- sectional study in Eastern China Open
Objectives This study aimed to explore the synergistic interaction effect between hyperuricemia and hypertension towards chronic kidney disease in patients with type 2 diabetes. Methods This research originates from a cross-sectional study…
View article: Onset of global instability in a premixed annular V-flame
Onset of global instability in a premixed annular V-flame Open
We investigate self-excited axisymmetric oscillations of a lean premixed methane--air V-flame in a laminar annular jet. The flame is anchored near the rim of the centrebody, forming an inverted cone, while the strongest vorticity is concen…
View article: Prolate spheroids settling in a quiescent fluid: clustering, microstructures and collisions
Prolate spheroids settling in a quiescent fluid: clustering, microstructures and collisions Open
In this study, we investigate the sedimentation of prolate spheroids in a quiescent fluid by means of the particle-resolved direct numerical simulation. With the increase of the particle volume fraction $ϕ$ from $0.1\%$ to $10\%$, we obser…
View article: Settling and collision of spheroidal particles with an offset mass centre in a quiescent fluid
Settling and collision of spheroidal particles with an offset mass centre in a quiescent fluid Open
Gravitational sedimentation and the collision of particles play key roles in various natural and engineering processes. In practice, particles are often non-spherical in shape with non-uniform mass distribution. In this study we investigat…
View article: Inflow turbulence generation for compressible turbulent boundary layers
Inflow turbulence generation for compressible turbulent boundary layers Open
It is still challenging to generate high-quality inflow turbulence for the direct numerical and large-eddy simulations of compressible turbulent boundary layers (CTBL). Recently, Wang et al. [“Inflow turbulence generation using an equivale…
View article: Characterization and evolution of local streamline geometry in an incompressible turbulent channel flow
Characterization and evolution of local streamline geometry in an incompressible turbulent channel flow Open
We investigated the statistical characterization and time evolution of local streamline geometry in typical regions of an incompressible turbulent channel flow at the friction Reynolds number Reτ∼1000. Local streamline structure is complet…
View article: Transport of inertial spherical particles in compressible turbulent boundary layers
Transport of inertial spherical particles in compressible turbulent boundary layers Open
In the present study, we perform direct numerical simulations of compressible turbulent boundary layers at the free stream Mach number of 2 ~ 6 laden with dilute phase of spherical particles to investigate the Mach number effects on partic…
View article: Multi-fidelity Bayesian optimization for spatially distributed control of flow over a circular cylinder
Multi-fidelity Bayesian optimization for spatially distributed control of flow over a circular cylinder Open
Bayesian optimization based on Gaussian process regression has recently spread into a range of computational fluid dynamics problems. It still remains to be explored and developed for the complex flow problems with high dimensions and larg…
View article: Predicting near-wall turbulence with minimal flow units in compressible turbulent channel flows
Predicting near-wall turbulence with minimal flow units in compressible turbulent channel flows Open
Mach number effects on the near-wall turbulence in the absence of outer motions remain unclear so far. The present study extends the Minimal Flow Units (MFUs), a widely applied method to investigate near-wall turbulence free from the impac…
View article: Supplementary Table S1.5 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer
Supplementary Table S1.5 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer Open
Validation hits.
View article: Supplementary Table S2 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer
Supplementary Table S2 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer Open
shRNAs used in manuscript.
View article: Supplementary Table S1.3 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer
Supplementary Table S1.3 from Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <i>LKB1</i>-Mutant Lung Cancer Open
Top 200 genes by W2ndB.
View article: Supplementary Figures 1-7 from Mutations in the <i>DDR2</i> Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
Supplementary Figures 1-7 from Mutations in the <i>DDR2</i> Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer Open
Supplementary Figures 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
View article: Supplementary Table 1 from Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors
Supplementary Table 1 from Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors Open
PDF file - 74K, Table describing clinical and molecular characteristics of NSCLC patients
View article: Supplementary Figure 1 from Acquired Resistance to Dasatinib in Lung Cancer Cell Lines Conferred by <i>DDR2</i> Gatekeeper Mutation and <i>NF1</i> Loss
Supplementary Figure 1 from Acquired Resistance to Dasatinib in Lung Cancer Cell Lines Conferred by <i>DDR2</i> Gatekeeper Mutation and <i>NF1</i> Loss Open
PDF - 96KB, Dasatinib treatment results in dephosphorylation of DDR2 in parental lines but not in parental lines expressing DDR2 T654I. This dephosphorylation is also observed following dasatinib treatment in NCI-H2286-DR but not in HCC-36…
View article: Supplementary Methods and Supplementary Figures S1 through S6 from NSCLC Driven by <i>DDR2</i> Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy
Supplementary Methods and Supplementary Figures S1 through S6 from NSCLC Driven by <i>DDR2</i> Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy Open
Supplementary Materials and Methods; Figure S1 characterization of mouse model, Figure S2 IHC analysis, Figure S3 DDR2 knock-down studies, Figure S4 cell line drug sensitivity, Figure S5 xenograft individual measurements, Figure S6 JQ1 hum…