Meichun Deng
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View article: Successful endovascular embolization of a cervical internal carotid artery fenestration associated with an aneurysm: a rare case report
Successful endovascular embolization of a cervical internal carotid artery fenestration associated with an aneurysm: a rare case report Open
Background: Fenestration of the cervical segment of the internal carotid artery is a rare cerebrovascular variation, and its origin is not fully understood. There are few reports of aneurysm with fenestration of the cervical segment of the…
View article: Retraction of Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice
Retraction of Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice Open
View article: Spider-derived peptide LCTx-F2 suppresses ASIC channels by occupying the acidic pocket
Spider-derived peptide LCTx-F2 suppresses ASIC channels by occupying the acidic pocket Open
View article: A possible drug interaction between sodium valproate and clonazepam resulting in severe drowsiness and limb weakness：A case report and literature review
A possible drug interaction between sodium valproate and clonazepam resulting in severe drowsiness and limb weakness：A case report and literature review Open
The treatment process of an 11-year-old girl diagnosed with Angelman syndrome, who experienced severe drowsiness and limb weakness following the combination of sodium valproate and clonazepam, is analyzed herein. Initially, the patient was…
View article: ACSL1 improves pulmonary fibrosis by reducing mitochondrial damage and activating PINK1/Parkin mediated mitophagy
ACSL1 improves pulmonary fibrosis by reducing mitochondrial damage and activating PINK1/Parkin mediated mitophagy Open
View article: Overactive PKA signaling underlies the hyperalgesia in an ADHD mouse model
Overactive PKA signaling underlies the hyperalgesia in an ADHD mouse model Open
There is an intimate relationship between pain hypersensitivity and attention deficit hyperactivity disorder (ADHD); however, the underlying mechanisms are still elusive. Individuals carrying the mutation in CRY1 (c. 1657 + 3A > C),…
View article: Spider venom-derived peptide JZTX-14 prevents migration and invasion of breast cancer cells via inhibition of sodium channels
Spider venom-derived peptide JZTX-14 prevents migration and invasion of breast cancer cells via inhibition of sodium channels Open
Nav1.5 channel is crucial for the proliferation and migration of breast cancer cells. In this study, we investigated the anticancer effect of JZTX-14, a natural peptide considered an effective antagonist of Nav1.5. First, we successfully i…
View article: A Novel Peptide from Polypedates megacephalus Promotes Wound Healing in Mice
A Novel Peptide from Polypedates megacephalus Promotes Wound Healing in Mice Open
Amphibian skin contains wound-healing peptides, antimicrobial peptides, and insulin-releasing peptides, which give their skin a strong regeneration ability to adapt to a complex and harsh living environment. In the current research, a nove…
View article: Correction: Liu et al. Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo. Biomedicines 2021, 9, 934
Correction: Liu et al. Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo. Biomedicines 2021, 9, 934 Open
In the original publication, there were mistakes in Figure 3C, Figure 6B and Figure S2A,B as published [...]
View article: [METTL27 is a prognostic biomarker of colon cancer and associated with immune invasion].
[METTL27 is a prognostic biomarker of colon cancer and associated with immune invasion]. Open
METTL27 is overexpressed in colon cancer and is associated with a poor prognosis of the patients. A high expression of METTL27 showed is associated less T cell immune infiltration, suggesting the potential of METTL27 as a prognostic marker…
View article: <i>GLRA2</i>gene mutations cause high myopia in humans and mice
<i>GLRA2</i>gene mutations cause high myopia in humans and mice Open
Background High myopia (HM) is a leading cause of blindness that has a strong genetic predisposition. However, its genetic and pathogenic mechanisms remain largely unknown. Thus, this study aims to determine the genetic profile of individu…
View article: Structure and Function of Sodium Channel Nav1.3 in Neurological Disorders
Structure and Function of Sodium Channel Nav1.3 in Neurological Disorders Open
View article: Roles of Phosphorylation of N-Methyl-d-Aspartate Receptor in Chronic Pain
Roles of Phosphorylation of N-Methyl-d-Aspartate Receptor in Chronic Pain Open
View article: Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo
Anti-Toxoplasma gondii Effects of a Novel Spider Peptide XYP1 In Vitro and In Vivo Open
Toxoplasmosis, caused by an obligate intracellular parasite Toxoplasma gondii, is one of the most prevalent zoonoses worldwide. Treatments for this disease by traditional drugs have shown numerous side effects, thus effective alternative a…
View article: Original Hosts, Clinical Features, Transmission Routes, and Vaccine Development for Coronavirus Disease (COVID-19)
Original Hosts, Clinical Features, Transmission Routes, and Vaccine Development for Coronavirus Disease (COVID-19) Open
The pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to public concern worldwide. Although a variety of hypotheses about the hosts of SARS-CoV-2 have …
View article: Protein Kinase C-Mediated Phosphorylation and α2δ-1 Interdependently Regulate NMDA Receptor Trafficking and Activity
Protein Kinase C-Mediated Phosphorylation and α2δ-1 Interdependently Regulate NMDA Receptor Trafficking and Activity Open
N-methyl-d-aspartate receptors (NMDARs) are important for synaptic plasticity associated with many physiological functions and neurologic disorders. Protein kinase C (PKC) activation increases the phosphorylation and activity of NMD…
View article: Comparison of cardiovascular outcomes and cardiometabolic risk factors between patients with type 2 diabetes treated with sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors: a meta-analysis
Comparison of cardiovascular outcomes and cardiometabolic risk factors between patients with type 2 diabetes treated with sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors: a meta-analysis Open
Aims Prevention of cardiovascular outcomes is a goal of the management of patients with type 2 diabetes mellitus patients as important as lowering blood glucose levels. Among the various glucose-lowering agents, the effects of sodium-gluco…
View article: Modalities and Mechanisms of Treatment for Coronavirus Disease 2019
Modalities and Mechanisms of Treatment for Coronavirus Disease 2019 Open
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly throughout the world. Although COVID-19 has a relatively low case severity rate compared to SARS and…
View article: Supplementary Material for: Analysis of axial length in young patients with Marfan syndrome and bilateral ectopia lentis by Z-scores
Supplementary Material for: Analysis of axial length in young patients with Marfan syndrome and bilateral ectopia lentis by Z-scores Open
Medicine
View article: Supplementary Material for: Analysis of axial length in young patients with Marfan syndrome and bilateral ectopia lentis by Z-scores
Supplementary Material for: Analysis of axial length in young patients with Marfan syndrome and bilateral ectopia lentis by Z-scores Open
Medicine
View article: Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao
Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao Open
Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom. In this report, we describe the purificatio…
View article: Supplementary Material for: Analysis of axial length in young patients with Marfan syndrome and bilateral ectopia lentis by Z-scores
Supplementary Material for: Analysis of axial length in young patients with Marfan syndrome and bilateral ectopia lentis by Z-scores Open
Medicine
View article: Venous thromboembolic events in patients with COVID-19: a systematic review and meta-analysis
Venous thromboembolic events in patients with COVID-19: a systematic review and meta-analysis Open
Background High incidence of venous thromboembolic complications in coronavirus disease 2019 (COVID-19) patients was noted recently. Objective This study aimed to explore the factors associated with prevalence of venous thromboembolism (VT…
View article: The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer
The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer Open
Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are involved in the metastatic process of invasion and migration. N…
View article: Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment
Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment Open
View article: Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao
Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao Open
Background: The tarantula Chilobrachys jingzhao is one of the largest venomous spiders in China. In previous studies, we purified and characterized at least eight peptides from C. jingzhao venom. In this report, we describe the purificatio…
View article: Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis
Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis Open
This study aimed to provide systematic evidence for the association between multiorgan dysfunction and COVID-19 development. Several online databases were searched for articles published until May 13, 2020. Two investigators independently …
View article: Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao
Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao Open
JZTX-X selectively suppresses Kv4.2 and Kv4.3 potassium channel activity in a concentration- and voltage-dependent manner and causes long-lasting mechanical hyperalgesia.
View article: α2δ-1–Bound N-Methyl-d-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents
α2δ-1–Bound N-Methyl-d-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents Open
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatm…
View article: Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain
Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain Open