Chun Ngo Yau
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View article: Superchaotropic Stabilization of Monomeric Protein States
Superchaotropic Stabilization of Monomeric Protein States Open
Chaotropes are long known to destabilize protein assemblies and folding. We report that a boron cluster ion, as a weakly coordinating superchaotrope, can paradoxically stabilize protein folding even under extended thermal stresses while br…
View article: Augmenting off-the-shelf enzyme activities by multiple folds with a supramolecular complex additive
Augmenting off-the-shelf enzyme activities by multiple folds with a supramolecular complex additive Open
View article: Superchaotropic stabilisation of monomeric protein states
Superchaotropic stabilisation of monomeric protein states Open
Chaotropes are long known to destabilise protein assemblies and folding. We report that a boron cluster ion, as a weakly coordinating superchaotrope, can paradoxically stabilise protein folding even under extended thermal stresses, while b…
View article: INSIHGT: an accessible multi-scale, multi-modal 3D spatial biology platform
INSIHGT: an accessible multi-scale, multi-modal 3D spatial biology platform Open
View article: INSIHGT: An accessible multi-scale, multi-modal 3D spatial biology platform
INSIHGT: An accessible multi-scale, multi-modal 3D spatial biology platform Open
Biological systems are complex, encompassing intertwined spatial, molecular and functional features. However, methodological constraints always limit the completeness of information that can be extracted. Here, we report the development of…
View article: INSIHGT - Scalable, Accessible, Homogeneous Deep Multiplexed Immunolabelling Platform for 3D Spatial Biology
INSIHGT - Scalable, Accessible, Homogeneous Deep Multiplexed Immunolabelling Platform for 3D Spatial Biology Open
View article: Principles of deep immunohistochemistry for 3D histology
Principles of deep immunohistochemistry for 3D histology Open
View article: Antibody stabilization for thermally accelerated deep immunostaining
Antibody stabilization for thermally accelerated deep immunostaining Open
Antibodies have diverse applications due to their high reaction specificities but are sensitive to denaturation when a higher working temperature is required. We have developed a simple, highly scalable and generalizable chemical approach …