Hsiao‐Chi Chuang
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View article: Associations between body composition, hydration status, and sleep architecture in obstructive sleep apnea
Associations between body composition, hydration status, and sleep architecture in obstructive sleep apnea Open
Introduction Obstructive sleep apnea (OSA) is linked to increased cardiovascular and metabolic risks. Although body mass index is a recognized risk factor, the roles of fat mass, muscle mass, and hydration status in influencing OSA severit…
View article: Oxidative stress triggers Itch-mediated TXNIP degradation and NF-κB activation promoting chronic obstructive pulmonary disease
Oxidative stress triggers Itch-mediated TXNIP degradation and NF-κB activation promoting chronic obstructive pulmonary disease Open
Background Chronic inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), are characterized by pulmonary structural changes, narrowing of the small airways, and destruction of the lung parenchyma caused by prol…
View article: Hippo signaling pathway regulated branching morphogenesis of fetal lung under hypoxia
Hippo signaling pathway regulated branching morphogenesis of fetal lung under hypoxia Open
Background Hypoxia affects embryonic development, leading to increased neonatal mortality. We investigated the effects of hypoxia on fetal lung branching via Hippo signaling pathway. Materials and methods Fetal lungs were dissected from 11…
View article: Acute and Recovery Phase Effects of Diesel Exhaust Particles on Lung and Brain in Mice
Acute and Recovery Phase Effects of Diesel Exhaust Particles on Lung and Brain in Mice Open
Air pollution is recognized as a risk factor for neurodegenerative diseases, but the effects of acute exposure and subsequent recovery from traffic-related air pollution remain unclear. This study aimed to investigate the acute and recover…
View article: ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells Open
Background Metals in particulate matter (PM), like iron (Fe), were associated with lung injury. Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) was suggested to inhibit lung inflammation. However, the effect of metals in PM, particula…
View article: Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of COPD through JNK-dependent and JNK-independent signalling
Particulate matter-related ITIH4 deficiency is associated with an emphysema phenotype of COPD through JNK-dependent and JNK-independent signalling Open
Background Prolonged exposure to airborne particulate matter (PM) is associated with emphysema and COPD; however, the precise underlying mechanism remains unclear. In a previous high-throughput screen, we identified inter-α-trypsin inhibit…
View article: Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypes
Seasonal variation of pediatric asthma exacerbations and its association with asthma phenotypes Open
Background The objective of this study was to examine the associations of blood inflammatory phenotypes with acute pediatric asthma exacerbations during different seasons and the COVID-19 pandemic. Methods A retrospective study was conduct…
View article: Oxidative Stress Triggers Itch-mediated TXNIP Degradation and NF-κB Activation Promoting Chronic Obstructive Pulmonary Disease
Oxidative Stress Triggers Itch-mediated TXNIP Degradation and NF-κB Activation Promoting Chronic Obstructive Pulmonary Disease Open
Background Chronic inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), are characterized by pulmonary structural changes, narrowing of the small airways, and destruction of the lung parenchyma caused by prol…
View article: Spectrum of rare EGFR mutations in Indonesian lung adenocarcinoma: Findings from an 8-year analysis of 4,778 cases highlighting the need for advanced targeted therapies
Spectrum of rare EGFR mutations in Indonesian lung adenocarcinoma: Findings from an 8-year analysis of 4,778 cases highlighting the need for advanced targeted therapies Open
Lung cancer patients in Indonesia exhibit a high prevalence of epidermal growth factor receptor (EGFR) mutations, with a substantial proportion attributed to rare or uncommon variants. The clinical significance of rare EGFR mutations lies …
View article: Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients
Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients Open
Background The objective of this study was to examine the effects of extreme temperatures on the gene signature and pathways of airway epithelial cells in mice and asthma patients. Methods We investigated the effects of temperature exposur…
View article: Corrigendum to ‘Extreme temperature increases the risk of COPD morbimortality: A systematic review and meta-analysis [Science of The Total Environment, Vol 958 [2025] 178087’
Corrigendum to ‘Extreme temperature increases the risk of COPD morbimortality: A systematic review and meta-analysis [Science of The Total Environment, Vol 958 [2025] 178087’ Open
This variability in response to extreme temperatures affects COPD morbidity and mortality, emphasizing the need for tailored medical and emergency responses to effectively mitigate health risks during extreme weather events.
View article: Joint effects of temperature and humidity with PM2.5 on COPD
Joint effects of temperature and humidity with PM2.5 on COPD Open
Background Particulate matter less than 2.5 microns in aerodynamic diameter (PM 2.5 ) is a significant air pollutant known to adversely affect respiratory health and increase the incidence of chronic obstructive pulmonary disease (COPD). F…
View article: Impact of PM <sub>2.5</sub> , relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei
Impact of PM <sub>2.5</sub> , relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei Open
Lower RH and temperature, contributing to deep sleep reduction and increased arousal, were influenced by elevated PM2.5 exposure, especially during colder months. Enhancing environmental quality and reducing PM2.5 levels may lead to improv…
View article: Maternal aspartame exposure alters lung Th1/Th2 cytokine balance in offspring through nuclear factor-κB activation
Maternal aspartame exposure alters lung Th1/Th2 cytokine balance in offspring through nuclear factor-κB activation Open
Our findings suggest maternal aspartame exposure influences lung Th1/Th2 cytokine balance in offspring through nuclear factor-κB activation.
View article: Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ regulatory T cells
Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ regulatory T cells Open
Allergic asthma is a chronic disease tied to unusual immune reactions involving type 2 T helper (Th2) cells specific to allergens. Dendritic cells (DCs) play a crucial role in guiding T-cell responses. Regulatory T (Treg) cells have the ab…
View article: Correlation Between mRNA Expression of Activated Eosinophils and Air Pollutant Exposure in Patients With Asthma
Correlation Between mRNA Expression of Activated Eosinophils and Air Pollutant Exposure in Patients With Asthma Open
Background Eosinophil activation is associated with asthma. Whether air pollution affects the activation of blood eosinophils in patients with asthma remains unknown. In this study, we investigated the correlation between transcriptional a…
View article: Eosinophilic inflammation: a key player in COPD pathogenesis and progression
Eosinophilic inflammation: a key player in COPD pathogenesis and progression Open
Understanding eosinophilic involvement in COPD can facilitate the development of precision medicine approaches, offering more tailored and effective treatment options. Future research should continue to focus on the integration of eosinoph…
View article: Characterization of airborne endotoxin in personal exposure to fine particulate matter (PM2.5) and bioreactivity for elderly residents in Hong Kong
Characterization of airborne endotoxin in personal exposure to fine particulate matter (PM2.5) and bioreactivity for elderly residents in Hong Kong Open
The heavy metals and bioreactivity properties of endotoxin in personal exposure to fine particulate matter (PM2.5) were characterized in the analysis. The average personal exposure concentrations to PM2.5 were ranged from 6.8 to 96.6 μg/m3…
View article: Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients
Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients Open
Background The impact of cigarette smoke (CS) on lung diseases and the role of microbiome dysbiosis in chronic obstructive pulmonary disease (COPD) have been previously reported; however, the relationships remain unclear. Methods Our resea…
View article: Effects of occupational exposure to metal fume PM2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study
Effects of occupational exposure to metal fume PM2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study Open
Objective This study investigates the associations of α1-antitrypsin, inter-α-trypsin inhibitor heavy chain (ITIH4), and 8-isoprostane with lung function in shipyard workers exposed to occupational metal fume fine particulate matter (PM 2.…
View article: Extreme temperatures increase the risk of pediatric pneumonia: a systematic review and meta-analysis
Extreme temperatures increase the risk of pediatric pneumonia: a systematic review and meta-analysis Open
Introduction The impact of climate change on ambient temperatures threatens to worsen pediatric pneumonia-related outcomes considerably. This study examined the associations of temperature variation and extreme temperature with pediatric p…
View article: Changes in Indoor Air Quality in Public Facilities before and after the Enactment of Taiwan’s Indoor Air Quality Management Act
Changes in Indoor Air Quality in Public Facilities before and after the Enactment of Taiwan’s Indoor Air Quality Management Act Open
South Korea was the first to administer the Indoor Air Quality Control Act in 1996, followed by Taiwan’s implementation in 2012. This study investigated indoor air quality (IAQ) in public facilities before and after the enactment of Taiwan…
View article: Prediction value of neutrophil and eosinophil count at risk of COPD exacerbation
Prediction value of neutrophil and eosinophil count at risk of COPD exacerbation Open
Our study indicates that distinct white blood cell profiles in COPD patients, with or without eosinophilic inflammation, can help assess the risk of AE in clinical settings.
View article: Emission Factors of PAHs Components and Bioreactivity in PM2.5 from Biomass Burning
Emission Factors of PAHs Components and Bioreactivity in PM2.5 from Biomass Burning Open
Biomass burning releases fine particulate matter (PM2.5), water-soluble inorganic ions (WSIs), metal elements, polycyclic aromatic hydrocarbons (PAHs) and other compounds, and it is one of the largest sources of carbonaceous aerosols. The …