Chia‐Chun Wu
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View article: Disseminated Cryptococcal Osteomyelitis Masquerading as Bone Metastases in a Nonhuman Immunodeficiency Virus Patient: A Case Report
Disseminated Cryptococcal Osteomyelitis Masquerading as Bone Metastases in a Nonhuman Immunodeficiency Virus Patient: A Case Report Open
A 71-year-old female presented with a mass on her right index finger. Initial radiographs revealed an eccentric lytic lesion in the proximal phalanx, accompanied by cortical destruction. Magnetic resonance imaging demonstrated a rim-enhanc…
View article: Comparing the stability of a novel h-shaped bone plate and commercial endosteal plating systems in hallux valgus correction
Comparing the stability of a novel h-shaped bone plate and commercial endosteal plating systems in hallux valgus correction Open
For stabilizing distal chevron osteotomies, the h-shaped bone plate showed greater resistance to displacement in the dorsal-to-plantar and medial-to-lateral directions than the commercially available implants evaluated in this study. The h…
View article: The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells
The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells Open
Local anesthetics are commonly used in various clinical settings for both prevention and symptom relief. Numerous clinical studies have demonstrated that intra-articular injections of local anesthetics achieve high success rates in orthope…
View article: ELIXCYTE®, an Allogenic Adipose-Derived Stem Cell Product, Mitigates Osteoarthritis by Reducing Inflammation and Preventing Cartilage Degradation In Vitro
ELIXCYTE®, an Allogenic Adipose-Derived Stem Cell Product, Mitigates Osteoarthritis by Reducing Inflammation and Preventing Cartilage Degradation In Vitro Open
Adipose-derived stem cells (ADSCs) comprise a promising therapy for osteoarthritis (OA). The therapeutic potential of ELIXCYTE®, an allogeneic human ADSC (hADSC) product, was demonstrated in a phase I/II OA clinical trial. However, the exa…
View article: Cervical Disc Arthroplasty (CDA) versus Anterior Cervical Discectomy and Fusion (ACDF) for Two-Level Cervical Disc Degenerative Disease: An Updated Systematic Review and Meta-Analysis
Cervical Disc Arthroplasty (CDA) versus Anterior Cervical Discectomy and Fusion (ACDF) for Two-Level Cervical Disc Degenerative Disease: An Updated Systematic Review and Meta-Analysis Open
Background: Anterior cervical discectomy and fusion (ACDF) and cervical disc arthroplasty (CDA) are both considered to be efficacious surgical procedures for treating cervical spondylosis in patients with or without compression myelopathy.…
View article: Near-infrared radiation of gold–platinum submicron particle-decorated nonwoven mats enhances wound healing: In vitro and In vivo studies
Near-infrared radiation of gold–platinum submicron particle-decorated nonwoven mats enhances wound healing: In vitro and In vivo studies Open
Because of their biocompatibility and unique optical and electrical properties, Pt nanoparticles (NPs) have been extensively utilized in biomedical applications. However, the use of pure Pt NPs is hindered by the high costs of raw material…
View article: Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells
Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells Open
Osteoarthritis is more prevalent than any other form of arthritis and is characterized by the progressive mechanical deterioration of joints. Glucosamine, an amino monosaccharide, has been used for over fifty years as a dietary supplement …
View article: The Effect of Listening to Pachelbel’s Canon in D Major on Anxiety Level during Pulmonary Rehabilitation: A Pilot Study
The Effect of Listening to Pachelbel’s Canon in D Major on Anxiety Level during Pulmonary Rehabilitation: A Pilot Study Open
Objective: Many patients with chronic obstructive pulmonary disease (COPD) feel anxious during the pulmonary rehabilitation process. How to reduce the anxious level in patients with COPD is a worthy issue for mental health. Johann Pachelbe…
View article: Abstract 2245 Discovery and functional characterization of potential biomarkers for wild-type EGFR lung adenocarcinoma via super-SILAC-based quantitative tissue proteomic analysis
Abstract 2245 Discovery and functional characterization of potential biomarkers for wild-type EGFR lung adenocarcinoma via super-SILAC-based quantitative tissue proteomic analysis Open
Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) accounts for 80% of all lung cancers, and adenocarcinoma (LUAD) is the most common subtype of NSCLC. Epidermal growth factor receptor (E…
View article: Investigation of Electronic Structures of Triplet States Using Step-Scan Time-Resolved Fourier-Transform Near-Infrared Spectroscopy
Investigation of Electronic Structures of Triplet States Using Step-Scan Time-Resolved Fourier-Transform Near-Infrared Spectroscopy Open
Triplet transitions of light-emitting materials, including rose bengal, tris(2-phenylpyridine)iridium(III) [Ir(ppy)3], tris(1-phenylisoquinoline)iridium(III) [Ir(piq)3], and bis[2-(4,6-difluorophenyl)pyridinato-C2,N](…
View article: Monitoring Cultured Rat Hepatocytes Using RNA-Seq In Vitro
Monitoring Cultured Rat Hepatocytes Using RNA-Seq In Vitro Open
Compared to other techniques, RNA sequencing (RNA-Seq) has the advantage of having details of the expression abundance of all transcripts in a single run. In this study, we used RNA-Seq to monitor the maturity and dynamic characteristics o…
View article: Pathogen inhibition and indication by gelatin nonwoven mats with incorporation of polyphenol derivatives
Pathogen inhibition and indication by gelatin nonwoven mats with incorporation of polyphenol derivatives Open
GgC nonwoven mats shows a real-time indication of pathogen levels in the surrounding air by color change (white to brown).
View article: NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis
NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis Open
Colorectal cancer (CRC) is one of the types of cancers with a high incidence and is ranked the 3rd among men and 2nd among women worldwide. The purpose of this study was to investigate the correlation between non-SMC condensin I complex su…
View article: Precise joint preserving surgery by using Three-Dimensional Printing Technology for metastatic periacetabular bone tumor: A technique note and preliminary report
Precise joint preserving surgery by using Three-Dimensional Printing Technology for metastatic periacetabular bone tumor: A technique note and preliminary report Open
With precise tumor resection and reconstruction with sandwich procedure, the joint-sparing surgery can be performed in selected patients with metastatic periacetabular tumors.
View article: Operating Room Usage Time Estimation with Machine Learning Models
Operating Room Usage Time Estimation with Machine Learning Models Open
Effectively handling the limited number of surgery operating rooms equipped with expensive equipment is a challenging task for hospital management such as reducing the case-time duration and reducing idle time. Improving the efficiency of …
View article: Bilateral Fractures of the Femoral Neck
Bilateral Fractures of the Femoral Neck Open
Bilateral fractures of the femoral neck are rare and are usually associated with underlying bone diseases, previous metabolic diseases, high-energy trauma, electroshock, or seizure attack. Low-energy trauma, such as a fall, related bilater…
View article: Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation
Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation Open
Objective: To use deep learning to predict the probability of triangular fibrocartilage complex (TFCC) injury in patients’ MRI scans. Methods: We retrospectively studied medical records over 11 years and 2 months (1 January 2009–29 Februar…
View article: Traditional versus Minimally Invasive Spinopelvic Fixation for Sacral Fracture Treatment in Vertically Unstable Pelvic Fractures
Traditional versus Minimally Invasive Spinopelvic Fixation for Sacral Fracture Treatment in Vertically Unstable Pelvic Fractures Open
Purpose: Numerous different fixation techniques are used to treat vertical shear sacral fractures. We report our experience with spinopelvic fixation using a minimally invasive technique. Methods: Thirty-eight patients with vertical pelvic…
View article: Deep Sea Water-Dissolved Organic Matter Intake Improves Hyperlipidemia and Inhibits Thrombus Formation and Vascular Inflammation in High-Fat Diet Hamsters
Deep Sea Water-Dissolved Organic Matter Intake Improves Hyperlipidemia and Inhibits Thrombus Formation and Vascular Inflammation in High-Fat Diet Hamsters Open
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by oxidative stress, inflammation and lipid deposition within liver cells, and is subsequently contributing to cardiovascular diseases such as atherosclerosis. Dee…
View article: Monitoring Cultured Rat Hepatocytes Using RNA-Seq In Vitro
Monitoring Cultured Rat Hepatocytes Using RNA-Seq In Vitro Open
View article: The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation
The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation Open
Purpose Genome-wide association studies have identified numerous genetic variants that are associated with osteoporosis risk; however, most of them are present in the non-coding regions of the genome and the functional mechanisms are unkno…
View article: Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis
Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis Open
Background Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. …
View article: Photovoltaic Module Fault Detection Based on a Convolutional Neural Network
Photovoltaic Module Fault Detection Based on a Convolutional Neural Network Open
With the rapid development of solar energy, the photovoltaic (PV) module fault detection plays an important role in knowing how to enhance the reliability of the solar photovoltaic system and knowing the fault type when a system problem oc…
View article: Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation
Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation Open
Background and Objectives: Gouty arthritis is an acute inflammatory response caused by the precipitation of monosodium urate (MSU) crystals in joints. The triggering of MSU leads to increased production of inflammatory cytokines, such as i…
View article: Clinical Efficacy of Polycaprolactone β-Calcium Triphosphate Composite for Osteoconduction in Rabbit Bone Defect Model
Clinical Efficacy of Polycaprolactone β-Calcium Triphosphate Composite for Osteoconduction in Rabbit Bone Defect Model Open
The combination of β-tricalcium phosphate (β-TCP) with polycaprolactone (PCL) has been considered a promising strategy for designing scaffolds for bone grafting. This study incorporated PCL with commercially available β-TCP (OsteoceraTM) t…
View article: Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1β-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway
Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1β-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway Open
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the deterioration of articular cartilage. The progression of OA leads to an increase in inflammatory mediators in the joints, thereby promoting the destruction of…
View article: Effects of Surgical Intervention for Bone Metastases on Survival in Patients with Advanced Cancer: A Nationwide Population-Based Cohort Study
Effects of Surgical Intervention for Bone Metastases on Survival in Patients with Advanced Cancer: A Nationwide Population-Based Cohort Study Open
This study demonstrates that surgical resection of metastatic bone lesions did not pose any additional risk to survival outcomes. Thus, we believe that surgery, if indicated, could have a competitive role in the management of metastatic bo…
View article: NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma
NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma Open
Background Leiomyosarcoma (LMS), the most common soft tissue sarcoma, exhibits heterogeneous and complex genetic karyotypes with severe chromosomal instability and rearrangement and poor prognosis. Methods Clinical variables associated wit…
View article: Polymorphism of rs6426749 at 1p36.12 is associated with the risk of osteoarthritis in Taiwanese female population
Polymorphism of rs6426749 at 1p36.12 is associated with the risk of osteoarthritis in Taiwanese female population Open
Background: Osteoarthritis (OA) is a multifactorial disease that is associated with several genetic factors. TFAP2A with a motif of C allele at rs6426749 demonstrates a higher binding ability, thereby increasing CDC42 expression, potential…
View article: Evaluation of Polyacrylonitrile Nonwoven Mats and Silver–Gold Bimetallic Nanoparticle-Decorated Nonwoven Mats for Potential Promotion of Wound Healing In Vitro and In Vivo and Bone Growth In Vitro
Evaluation of Polyacrylonitrile Nonwoven Mats and Silver–Gold Bimetallic Nanoparticle-Decorated Nonwoven Mats for Potential Promotion of Wound Healing In Vitro and In Vivo and Bone Growth In Vitro Open
We prepared polyacrylonitrile (PAN) and urchin-like Ag–Au bimetallic or Ag nanoparticle-decorated PAN nonwoven mats using electrospinning and evaluated them in vitro and in vivo for wound healing, antibacterial effects on skin tissue, and …