Yan Huang
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View article: Evaluating metastatic risk in breast cancer through CTCs and L1CAM expression
Evaluating metastatic risk in breast cancer through CTCs and L1CAM expression Open
Introduction Circulating tumor cells (CTCs) and L1 cell adhesion molecule (L1CAM) are associated with breast cancer (BC) metastasis. This study investigated their potential as predictive biomarkers for lymph node metastasis in early-stage …
View article: Adaptive capacity and performance-based funding effectiveness: evidence from Chinese vocational education
Adaptive capacity and performance-based funding effectiveness: evidence from Chinese vocational education Open
Employing a mixed-methods research design, the study combines closed-ended Likert surveys (54 items, α = 0.78–0.93), semi-structured elite interviews guided by a standardized protocol including open-ended thematic questions, and document a…
View article: Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes
Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes Open
Type 2 diabetes (T2D) is increasingly recognized as a risk factor for cognitive impairment, ranging from mild cognitive impairment (MCI) to dementia. The underlying mechanisms involve a complex interplay of hyperglycemia, insulin resistanc…
View article: Effectiveness and safety of acupuncture for Parkinson’s disease anxiety: a systematic review and meta-analysis
Effectiveness and safety of acupuncture for Parkinson’s disease anxiety: a systematic review and meta-analysis Open
Background Individuals with Parkinson’s disease (PD) commonly experience anxiety, with a prevalence of 31%. This study systematically evaluates the efficacy and safety of acupuncture for anxiety related to PD. Method Nine databases were se…
View article: Tillage Effects on Bacterial Community Structure and Ecology in Seasonally Frozen Black Soils
Tillage Effects on Bacterial Community Structure and Ecology in Seasonally Frozen Black Soils Open
Against the backdrop of global climate change intensifying seasonal freeze–thaw cycles, deteriorating soil conditions in farmland within seasonal frost zones constrain agricultural sustainability. This study employed an in situ field exper…
View article: Development and validation of an early diagnostic model to distinguish bacterial infection in patients with acute-on-chronic liver disease (AoCLD) and systemic inflammatory response syndrome (SIRS): a post-hoc analysis of a prospective multicenter cohort
Development and validation of an early diagnostic model to distinguish bacterial infection in patients with acute-on-chronic liver disease (AoCLD) and systemic inflammatory response syndrome (SIRS): a post-hoc analysis of a prospective multicenter cohort Open
The early diagnostic model developed in this study effectively differentiates between infectious and non-infectious SIRS in AoCLD patients, potentially reducing unnecessary antimicrobial exposure and improving clinical outcomes.
View article: Stochastic Distributionally Robust Optimization Scheduling of High-Proportion New Energy Distribution Network Considering Detailed Modeling of Energy Storage
Stochastic Distributionally Robust Optimization Scheduling of High-Proportion New Energy Distribution Network Considering Detailed Modeling of Energy Storage Open
In the context of building a new type of power system, the optimal operation of high-proportion new-energy distribution networks (HNEDNs) is a current hot topic. In this paper, a stochastic distribution robust optimization method for HNEDN…
View article: Effectiveness of Photodynamic Therapy, 2% Salicylic Acid, and Their Combination for Moderate Acne
Effectiveness of Photodynamic Therapy, 2% Salicylic Acid, and Their Combination for Moderate Acne Open
Photodynamic therapy combined with 2% salicylic acid therapy reduced the number of skin lesions in patients with moderate acne more than either treatment alone. The combination therapy may be tolerable with no severe adverse reactions.
View article: Causal associations between genetically predicted placental weight and migraine
Causal associations between genetically predicted placental weight and migraine Open
Background Placental weight (PW) is a crucial factor in fetal development, influencing various health outcomes throughout life. This study investigates whether there is a causal relationship between PW and the risk of developing migraine. …
View article: Comprehensive Analysis Reveals the Molecular Features and Immune Infiltration of PANoptosis-Related Genes in Metabolic Dysfunction-Associated Steatotic Liver Disease
Comprehensive Analysis Reveals the Molecular Features and Immune Infiltration of PANoptosis-Related Genes in Metabolic Dysfunction-Associated Steatotic Liver Disease Open
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic inflammatory disorder characterized by alcohol-independent hepatic lipid accumulation, remains poorly understood in terms of PANoptosis involvement. Me…
View article: Evaluating the tumor response assessment of modified-RECIST 1.1 in advance non-small cell lung cancer: a post-hoc analysis of 1,147 patients from the EAST-LC trial
Evaluating the tumor response assessment of modified-RECIST 1.1 in advance non-small cell lung cancer: a post-hoc analysis of 1,147 patients from the EAST-LC trial Open
mRECIST 1.1 was comparable to RECIST 1.1 and might be preferable owing to its convenience in the assessment of tumor response in advanced NSCLC.
View article: Differential effects of rice irrigation modes on hydrothermal environment and yield from the perspective of TOPSIS model
Differential effects of rice irrigation modes on hydrothermal environment and yield from the perspective of TOPSIS model Open
In order to clarify the effects of different water-saving irrigation modes on hydrothermal changes in paddy fields in the black soil zone, field experiments were set up in paddy fields in the standard black soil zone in 2023 and 2024 to in…
View article: Enhancing autonomous exploration for robotics via real time map optimization and improved frontier costs
Enhancing autonomous exploration for robotics via real time map optimization and improved frontier costs Open
Autonomous exploration and mapping in unknown environments remain pivotal in robotics research. The efficiency of autonomous exploration is often constrained by irrational exploration strategies and incomplete map exploration. This paper p…
View article: Causal Relationship Between Abortion and Endometriosis: A Bidirectional Two‐Sample Mendelian Randomization Study
Causal Relationship Between Abortion and Endometriosis: A Bidirectional Two‐Sample Mendelian Randomization Study Open
Problem The relationship between abortion and endometriosis (EMS) has been inconsistent in previous observational studies and remains controversial. We intended to examine the causal relationship between abortion and EMS. Methods of Study …
View article: Optical–Thermal Performance and Energy Efficiency of Electrochromic Glazing in Hot Summer and Warm Winter Residential Buildings
Optical–Thermal Performance and Energy Efficiency of Electrochromic Glazing in Hot Summer and Warm Winter Residential Buildings Open
This study examined the optical–thermal performance and energy efficiency of electrochromic (EC) glazing in residential buildings situated in regions characterized by hot summers and warm winters. Traditional glazing systems, such as doubl…
View article: Determinants of Leptomeningeal Collateral Status in Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis of Observational Studies
Determinants of Leptomeningeal Collateral Status in Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis of Observational Studies Open
Background Leptomeningeal collateral status is a major determinant of outcomes in patients with acute ischemic stroke; however, the factors that determine collateral status are not well understood. We conducted a comprehensive systematic r…
View article: Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner
Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner Open
Despite the importance of cellular senescence in human health, how damaged cells undergo senescence remains elusive. We have previously shown that promyelocytic leukemia nuclear body (PML-NBs) translocation of the ciliary FBF1 is essential…
View article: Single‐cell <scp>RNA</scp> sequencing reveals the <scp>CRTAC1</scp><sup>+</sup> population actively contributes to the pathogenesis of spinal ligament degeneration by <scp>SPP1</scp><sup>+</sup> macrophage
Single‐cell <span>RNA</span> sequencing reveals the <span>CRTAC1</span><sup>+</sup> population actively contributes to the pathogenesis of spinal ligament degeneration by <span>SPP1</span><sup>+</sup> macrophage Open
Degenerative spinal stenosis is a chronic disease that affects the spinal ligaments and associated bones, resulting in back pain and disorders of the limbs among the elderly population. There are few preventive strategies for such ligament…
View article: Periorbital purpura can be the only initial symptom of primary light chain amyloidosis: A case report
Periorbital purpura can be the only initial symptom of primary light chain amyloidosis: A case report Open
BACKGROUND Primary light chain amyloidosis is a rare and complex disease with complex clinical features and is highly susceptible to misdiagnosis and underdiagnosis in the early stages. CASE SUMMARY We report a case of a 47-year-old female…
View article: Analyzing the characteristics of respiratory microbiota after the placement of an airway stent for malignant central airway obstruction
Analyzing the characteristics of respiratory microbiota after the placement of an airway stent for malignant central airway obstruction Open
Malignant central airway stenosis is treated with airway stent placement, but post-placement microbial characteristics remain unclear. We studied microbial features in 60 patients post-stent placement, focusing on changes during granulatio…
View article: Salvianolic Acid B Reduces Oxidative Stress to Promote Hair-Growth in Mice, Human Hair Follicles and Dermal Papilla Cells
Salvianolic Acid B Reduces Oxidative Stress to Promote Hair-Growth in Mice, Human Hair Follicles and Dermal Papilla Cells Open
The study indicates that SAB promotes hDPC proliferation and offers protection against oxidative stress, highlighting its potential as a therapeutic agent for enhancing hair growth and treating hair loss.
View article: Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy
Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy Open
Lung cancer is a prevalent and highly lethal disease often complicated by lower respiratory tract infections. Microbial patterns in these infections vary based on treatment modalities. The present study explored the impact of lung cancer t…
View article: Effects of virtual distant viewing technology on preventing nearwork-induced ocular parameter changes
Effects of virtual distant viewing technology on preventing nearwork-induced ocular parameter changes Open
Purpose This study investigates whether virtual distant viewing technology can prevent nearwork-induced ocular parameter changes. Methods Twenty-six volunteers read a textbook on one day and the same content on a virtual distant viewing di…