Yang Liu
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View article: Assessment of Health-Related Quality of Life and Influencing Factors among Patients with Advanced Schistosomiasis Japonica in the Southwest of China Using the EQ-5D-5L Scale
Assessment of Health-Related Quality of Life and Influencing Factors among Patients with Advanced Schistosomiasis Japonica in the Southwest of China Using the EQ-5D-5L Scale Open
Background To assess health-related quality of life (HRQoL) and identify influencing factors impacting HRQoL among patients with Advanced Schistosomiasis (AS) in Sichuan Province, China, utilizing the EQ-5D-5L scale. Methods A cross-sectio…
View article: Revealing the multi factor nonlinear response of carbon storage in the Yellow River Basin.
Revealing the multi factor nonlinear response of carbon storage in the Yellow River Basin. Open
View article: Influence of low transformation temperature (LTT) welding consumable on microstructure and deformation behavior of welded joint
Influence of low transformation temperature (LTT) welding consumable on microstructure and deformation behavior of welded joint Open
Low transformation temperature (LTT) welding consumables significantly influence mechanical properties. This work investigates the effect of LTT welding consumables on the microstructure and tensile deformation behavior of welded joints. T…
View article: Integrative profiling strategies to guide personalized therapy in mantle cell lymphoma: a pilot study
Integrative profiling strategies to guide personalized therapy in mantle cell lymphoma: a pilot study Open
Mantle cell lymphoma (MCL) responds to frontline therapy but is susceptible to relapse. While Bruton's tyrosine kinase inhibitors (BTKi) achieve high response rates, most patients eventually experience disease progression. Predicting respo…
View article: Prognostic Prediction of Advanced Intrahepatic Cholangiocarcinoma Patients Receiving Chemotherapy Combined with Immunotherapy Based on Serum Lipid Profiles
Prognostic Prediction of Advanced Intrahepatic Cholangiocarcinoma Patients Receiving Chemotherapy Combined with Immunotherapy Based on Serum Lipid Profiles Open
Background: Lipid metabolic reprogramming plays a critical role in tumor progression. Serum lipid levels have been associated with the prognosis of various malignancies. Aims: To develop a novel nomogram based on serum lipid parameters to …
View article: Machine learning models predict mortality risk in diabetic neuropathy patients using MIMIC-IV data
Machine learning models predict mortality risk in diabetic neuropathy patients using MIMIC-IV data Open
View article: CHG combined with venetoclax and azacytidine as induction chemotherapy in acute myeloid leukemia
CHG combined with venetoclax and azacytidine as induction chemotherapy in acute myeloid leukemia Open
Background: The survival rate of patients diagnosed with acute myeloid leukemia (AML) has shown improvement in recent decades. However, the induction chemotherapy regimen for AML still relies on the standard 7+3 regimen. Standard 7+3 regim…
View article: Inhibition of CPT1A reverses AML1-ETO-induced differentiation blockage by activating BCL-2/MYC signaling and metabolic reprogramming
Inhibition of CPT1A reverses AML1-ETO-induced differentiation blockage by activating BCL-2/MYC signaling and metabolic reprogramming Open
Objectives: Recent studies have increasingly highlighted the pivotal role of fatty acid metabolism in regulating hematopoietic stem cells (HSCs) fate and its influence on tumorigenesis, metastasis, and the development of drug resistance. C…
View article: Knee joint-fluid proteomics reveals potential diagnostic and prognostic biomarkers to distinguish between septic vs. autoimmune arthritis in children 2505
Knee joint-fluid proteomics reveals potential diagnostic and prognostic biomarkers to distinguish between septic vs. autoimmune arthritis in children 2505 Open
Description The evaluation of children with suspected septic arthritis is challenging due to the high rate of negative cultures and the consideration of inflammatory and reactive conditions. We assessed the potential clinical value of knee…
View article: 544 A phase I/II clinical trial of anti-CLDN18.2/PD-L1 recombinant humanized bispecific antibody Q-1802 combined with XELOX chemotherapy in untreated advanced GC/GEJ patients
544 A phase I/II clinical trial of anti-CLDN18.2/PD-L1 recombinant humanized bispecific antibody Q-1802 combined with XELOX chemotherapy in untreated advanced GC/GEJ patients Open
View article: IMMU-85. Uncovering differences in local and systemic immunity in human primary and metastatic brain tumors
IMMU-85. Uncovering differences in local and systemic immunity in human primary and metastatic brain tumors Open
While therapies targeting T cell immune checkpoint receptors have demonstrated clinical efficacy for patients with brain metastases, adults with high-grade gliomas fail to benefit. We comprehensively profiled intratumoral and circulating T…
View article: TMIC-01. Glycoprotein-NMB mediates GSC-TAM symbiosis to promote glioblastoma progression
TMIC-01. Glycoprotein-NMB mediates GSC-TAM symbiosis to promote glioblastoma progression Open
Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioblastoma stem cells (GSCs) that interaction with surrounding cells, including infiltrating tumor-associated macrophages and microglia (TAMs). While GSCs and TAMs …
View article: MUL1, an Immune Chemokine-Related Gene, Regulates Glioma Cell Proliferation and Migration: Insights from Functional and Mechanistic Studies
MUL1, an Immune Chemokine-Related Gene, Regulates Glioma Cell Proliferation and Migration: Insights from Functional and Mechanistic Studies Open
Background Glioma is the most common and lethal type of brain tumor, characterized by poor prognosis and high recurrence rates. Immune dysfunction and inflammatory infiltration within the tumor microenvironment (TME) are two hallmarks of g…
View article: From Data Mining to Functional Validation: UBE2S Regulates Proliferation and Radiosensitivity in Colorectal Cancer via the PI3K/AKT Pathway
From Data Mining to Functional Validation: UBE2S Regulates Proliferation and Radiosensitivity in Colorectal Cancer via the PI3K/AKT Pathway Open
Background Colorectal cancer is the third most common malignant tumor worldwide, accounting for approximately 10% of all newly diagnosed cancer cases annually. UBE2S has been demonstrated to play an oncogenic role in various types of cance…
View article: Design and fabrication of microfluidic chip and integrated nucleic acid rapid diagnosis device
Design and fabrication of microfluidic chip and integrated nucleic acid rapid diagnosis device Open
African Swine Fever (ASF) poses a severe threat to the global pig husbandry. In the absence of an effective vaccine, developing rapid and accurate diagnostic methods is crucial for epidemic control. This study designed a low-cost microflui…
View article: A Novel Strategy for Condition Assessment: Predicting Major Adverse Cardiovascular Events Post-Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients via CXCR7 and Its Ligand CXCL12
A Novel Strategy for Condition Assessment: Predicting Major Adverse Cardiovascular Events Post-Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients via CXCR7 and Its Ligand CXCL12 Open
Objective: The chemokine receptor CXCR7 and its ligand CXCL12 are critically involved in coronary microenvironment repair. Yet, their clinical relevance in diagnosing acute myocardial infarction (AMI) and forecasting post-percutaneous coro…
View article: Efficacy and safety of TAS-102 plus Surufatinib in third and later line metastatic pancreatic cancer: a prospective, single center and biomarker exploratory, phase II study
Efficacy and safety of TAS-102 plus Surufatinib in third and later line metastatic pancreatic cancer: a prospective, single center and biomarker exploratory, phase II study Open
View article: CST7+ macrophages/monocytes in melanoma: single-cell insights into immunotherapy response
CST7+ macrophages/monocytes in melanoma: single-cell insights into immunotherapy response Open
These findings suggest that CST7+ macrophages/monocytes are associated with immunotherapy response by correlating with cytotoxic T-cell activation through the ICOSL/ICOS pathway. The observed interaction highlights the potential…
View article: Cementum regeneration strategies: Insights from development and periodontal microenvironment
Cementum regeneration strategies: Insights from development and periodontal microenvironment Open
Cementum, a mineralized tissue covering the root surface of the tooth, maintains tooth stability through providing support for the attachment of periodontal ligament fibres, and protects the pulp from external damage via acting as a barrie…
View article: Nutritional status indices on the prognosis of patients with relapsed and refractory multiple myeloma treated with CAR-T cell immunotherapy
Nutritional status indices on the prognosis of patients with relapsed and refractory multiple myeloma treated with CAR-T cell immunotherapy Open
Background aims Chimeric antigen receptor (CAR) T-cell therapy shows remarkable efficacy against relapsed/refractory multiple myeloma (R/R MM). Nutritional status, assessed by objective indices like the Controlling Nutritional Status (CONU…
View article: Clinical Value of APRI and FIB-4 on Bleeding Risk and 30-Day Prognosis in Patients with Liver Cirrhosis Complicated with Esophagogastric Varices
Clinical Value of APRI and FIB-4 on Bleeding Risk and 30-Day Prognosis in Patients with Liver Cirrhosis Complicated with Esophagogastric Varices Open
APRI, FIB-4, and WBC serve as independent EGVB predictors. The developed nomogram provides an effective screening tool, while the identified high-risk thresholds (APRI≥10.27, FIB-4≥19.03) offer valuable clinical warning indicators, enablin…
View article: [Expression of Concern] microRNA‑99a is downregulated and promotes proliferation, migration and invasion in non‑small cell lung cancer A549 and H1299 cells
[Expression of Concern] microRNA‑99a is downregulated and promotes proliferation, migration and invasion in non‑small cell lung cancer A549 and H1299 cells Open
View article: Nomogram for predicting the occurrence of progressive ischemic stroke: a single-center retrospective study
Nomogram for predicting the occurrence of progressive ischemic stroke: a single-center retrospective study Open
View article: Clinical study on the correlation between syndrome types and Traditional Chinese Medicine constitution in 409 cases of female infertility
Clinical study on the correlation between syndrome types and Traditional Chinese Medicine constitution in 409 cases of female infertility Open
View article: Assessing Students’Clinical Reasoning Skills in History Taking with Large Language Model–Based Virtual Patients: Development and Validation of a Structured Coding Scheme Using Systematic Text Condensation (Preprint)
Assessing Students’Clinical Reasoning Skills in History Taking with Large Language Model–Based Virtual Patients: Development and Validation of a Structured Coding Scheme Using Systematic Text Condensation (Preprint) Open
BACKGROUND Large language model (LLM)-driven virtual patients (VPs) are increasingly used to simulate history taking. However, there is currently no straightforward methodological approach to effectively identify students’ clinical reason…
View article: Preclinical Evaluation of a Novel Carbonic Anhydrase IX-Targeting 68Ga/177Lu Theranostic Pair for Clear Cell Renal Cell Carcinoma
Preclinical Evaluation of a Novel Carbonic Anhydrase IX-Targeting 68Ga/177Lu Theranostic Pair for Clear Cell Renal Cell Carcinoma Open
Background Carbonic anhydrase IX (CAIX) is a hypoxia-regulated enzyme overexpressed in clear cell renal cell carcinoma (ccRCC) but minimally in normal tissues, making it a promising theranostic target. Current imaging modalities for ccRCC …
View article: A Deep Learning–Random Forest Hybrid Model for Predicting Historical Temperature Variations Driven by Air Pollution: Methodological Insights from Wuhan
A Deep Learning–Random Forest Hybrid Model for Predicting Historical Temperature Variations Driven by Air Pollution: Methodological Insights from Wuhan Open
With the continuous acceleration of industrialization, air pollution has become increasingly severe and has, to some extent, contributed to the progression of global climate change. Against this backdrop, accurate temperature forecasting p…
View article: Innate and adaptive immune features associated with immune-related adverse events
Innate and adaptive immune features associated with immune-related adverse events Open
Background While highly efficacious for numerous cancers, immune checkpoint inhibitors (ICIs) can cause unpredictable and potentially severe immune-related adverse events (irAEs), underscoring the need to understand irAE biology. Methods W…
View article: First case report of immune checkpoint inhibitor-related pneumonitis triggered by bispecific antibody (anti-PD-L1 and anti-CTLA-4) in a patient with non-small cell lung cancer: case report
First case report of immune checkpoint inhibitor-related pneumonitis triggered by bispecific antibody (anti-PD-L1 and anti-CTLA-4) in a patient with non-small cell lung cancer: case report Open
This case represents the first reported instance of ICI-P induced by a bispecific antibody targeting PD-L1 and CTLA-4, with a comprehensive account of its clinical course and management. Compared to conventional dual ICI regimens, bispecif…
View article: Exchangeable heavy metals promote the amplification of heavy metal resistance genes: A case study from Southwest China
Exchangeable heavy metals promote the amplification of heavy metal resistance genes: A case study from Southwest China Open