Chunchu Deng
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View article: Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy Open
View article: Loss of synaptic Munc13-1 underlies neurotransmission abnormalities in spinal muscular atrophy
Loss of synaptic Munc13-1 underlies neurotransmission abnormalities in spinal muscular atrophy Open
Spinal muscular atrophy (SMA) is a devastating neurodegenerative disease characterized by degeneration of spinal motoneurons, leading to muscle atrophy and synaptic loss. SMN functions in mRNA splicing, transport, and local translation are…
View article: Application of Biomarkers in Spinal Muscular Atrophy
Application of Biomarkers in Spinal Muscular Atrophy Open
Spinal muscular atrophy (SMA) is a fatal motor neuron disease characterized by five clinical subtypes, each presenting with different rates of disease progression and varying responses to recently approved therapies. The identification of …
View article: Unveiling the genetic association between rheumatoid arthritis and four common hand pathologies
Unveiling the genetic association between rheumatoid arthritis and four common hand pathologies Open
Our results indicate that RA is an independent genetic factor contributing to CTS and TF, but not to DQT or DD. This finding supports recommendations aimed at preventing the occurrence of CTS and TF in patients with RA. However, further hi…
View article: Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study
Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study Open
Peripheral nerve injury (PNI) remains a significant clinical challenge, often leading to long-term functional impairment. Despite advances in therapies, current repair strategies offer unsatisfactory clinical outcomes. Exosomes derived fro…
View article: Advancements in Proteolysis Targeting Chimeras for Targeted Therapeutic Strategies in Alzheimer’s Disease
Advancements in Proteolysis Targeting Chimeras for Targeted Therapeutic Strategies in Alzheimer’s Disease Open
View article: Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia
Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia Open
Small extracellular vesicles (sEVs), including exosomes as a subtype, with a diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting a diverse array of bioactive molecules, including prote…
View article: Mechanisms and Countermeasures for Muscle Atrophy in Microgravity
Mechanisms and Countermeasures for Muscle Atrophy in Microgravity Open
Previous studies have revealed that muscle atrophy emerges as a significant challenge faced by astronauts during prolonged missions in space. A loss in muscle mass results in a weakening of skeletal muscle strength and function, which will…
View article: Loss of Synaptic Munc13-1 Underlies Neurotransmission Abnormalities in Spinal Muscular Atrophy
Loss of Synaptic Munc13-1 Underlies Neurotransmission Abnormalities in Spinal Muscular Atrophy Open
Spinal muscular atrophy (SMA) is a devastating neurodegenerative disease characterized by degeneration of spinal motoneurons, leading to muscle atrophy and synaptic loss. SMN functions in mRNA splicing, transport, and local translation are…
View article: Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives Open
“Peripheral nerve injury” refers to damage or trauma affecting nerves outside the brain and spinal cord. Peripheral nerve injury results in movements or sensation impairments, and represents a serious public health problem. Although severe…
View article: Regenerative rehabilitation: a novel multidisciplinary field to maximize patient outcomes
Regenerative rehabilitation: a novel multidisciplinary field to maximize patient outcomes Open
Regenerative rehabilitation is a novel and rapidly developing multidisciplinary field that converges regenerative medicine and rehabilitation science, aiming to maximize the functions of disabled patients and their independence. While rege…
View article: Treadmill Exercise Improves Cerebral Ischemia Injury by Regulating Microglia Polarization Via Downregulation of MMP12
Treadmill Exercise Improves Cerebral Ischemia Injury by Regulating Microglia Polarization Via Downregulation of MMP12 Open
View article: Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in spinal muscular atrophy and amyotrophic lateral sclerosis
Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in spinal muscular atrophy and amyotrophic lateral sclerosis Open
Tropomyosin receptor kinase B (TrkB) and its primary ligand brain-derived neurotrophic factor (BDNF) are expressed in the neuromuscular system, where they affect neuronal survival, differentiation, and functions. Changes in BDNF levels and…
View article: Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy Open
Plastin 3 (PLS3) is an F-actin-bundling protein that has gained attention as a modifier of spinal muscular atrophy (SMA) pathology. SMA is a lethal pediatric neuromuscular disease caused by loss of or mutations in the Survival Motor Neuron…
View article: <scp>hnRNP</scp> R negatively regulates transcription by modulating the association of <scp>P‐TEFb</scp> with <scp>7SK</scp> and <scp>BRD4</scp>
<span>hnRNP</span> R negatively regulates transcription by modulating the association of <span>P‐TEFb</span> with <span>7SK</span> and <span>BRD4</span> Open
View article: Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy
Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy Open
View article: First person – Chunchu Deng
First person – Chunchu Deng Open
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Chunchu Deng is co-first author on ‘ D…
View article: Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons
Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons Open
In neurons, the endoplasmic reticulum (ER) forms a highly dynamic network that enters axons and presynaptic terminals and plays a central role in Ca2+ homeostasis and synapse maintenance; however, the underlying mechanisms involved in regu…
View article: Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons
Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons Open
In neurons, endoplasmic reticulum forms a highly dynamic network that enters axons and presynaptic terminals and plays a central role in Ca 2+ homeostasis and synapse maintenance. However, the underlying mechanisms involved in regulation o…
View article: Dynamic remodeling of presynaptic endoplasmic reticulum is coordinated through actin and microtubule crosstalk and contributes to defective stimulus-response in Spinal Muscular Atrophy
Dynamic remodeling of presynaptic endoplasmic reticulum is coordinated through actin and microtubule crosstalk and contributes to defective stimulus-response in Spinal Muscular Atrophy Open
Background Axonal degeneration and defects in neuromuscular neurotransmission represent a pathological hallmark in spinal muscular atrophy (SMA) and other forms of motoneuron disease. These pathological changes do not only base on altered …
View article: Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function Open
View article: Additional file 1 of Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function
Additional file 1 of Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function Open
Additional file 1: Supplementary Table 1. List of primers for cloning of shRNAs into pSIH. siRNA sequences are underlined. Supplementary Table 2. List of qPCR primers. Supplementary Table 3. List of transcripts significantly (p<0.05) upreg…