Chun’e Li
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View article: Application of SIFT operator with binocular vision fusion in Building engineering measurement
Application of SIFT operator with binocular vision fusion in Building engineering measurement Open
With the increasing demand for higher accuracy and reliability in the field of engineering measurement, traditional methods have shown a series of problems when facing complex scenarios and precision measurement tasks. Therefore, a scale i…
View article: A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals
A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals Open
Objective This study aimed to identify candidate loci and genes related to sleep disturbances in depressed individuals and clarify the co-occurrence of sleep disturbances and depression from the genetic perspective. Methods The study subje…
View article: A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study
A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study Open
Our findings reveal the positive effects of multidimensional social factors on the risk of depression and anxiety. It is important to address key social disadvantage in mental health promotion and treatment.
View article: Insight into the Causal Relationship between Gut Microbiota and Back Pain: A Two Sample Bidirectional Mendelian Randomization Study
Insight into the Causal Relationship between Gut Microbiota and Back Pain: A Two Sample Bidirectional Mendelian Randomization Study Open
Observational studies have shown that alterations in gut microbiota composition are associated with low back pain. However, it remains unclear whether the association is causal. To reveal the causal association between gut microbiota and l…
View article: A genetic correlation analysis between addiction-related traits and chronic bowel disorders
A genetic correlation analysis between addiction-related traits and chronic bowel disorders Open
Aims Addiction is currently seen as a neuropsychiatric disorder with genetic component involved. Multiple chronic bowel disorders could exert influence on mental status including addition. This study aims to investigate the genetic correla…
View article: Research on a fuzzy algorithm for intelligent power-saving control of urban street lamps
Research on a fuzzy algorithm for intelligent power-saving control of urban street lamps Open
Urbanisation has increased the demand for energy-efficient and environmentally friendly street lighting systems. However, traditional urban lighting uses time interval control and cannot be intelligently controlled according to the environ…
View article: Mitochondria-wide association study observed significant interactions of mitochondrial respiratory and the inflammatory in the development of anxiety and depression
Mitochondria-wide association study observed significant interactions of mitochondrial respiratory and the inflammatory in the development of anxiety and depression Open
The aim of this study was to investigate the possible interaction of mitochondrial dysfunction and inflammatory cytokines in the risk of anxiety and depression. We utilized the UK Biobank for the sample of this study. A mitochondria-wide a…
View article: The causal relationship between gut microbiome and carpal tunnel syndrome:A two-sample Mendelian Randomization Study
The causal relationship between gut microbiome and carpal tunnel syndrome:A two-sample Mendelian Randomization Study Open
Objective There is considerable evidence linking gut microbiome to bone-joint diseases, but no studies explored the causal association between gut microbiome and carpal tunnel syndrome (CTS). Methods This study utilized large-scale genome-…
View article: Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort Open
There is a strong link between irritable bowel syndrome and brain volumes, yet, to date, research examining the mediators of this association has been little. Based on the phenotypic data of 15 248 participants from the UK Biobank, a two-s…
View article: Evaluation Method of Equalization of Basic Medical Services from the Spatial Perspective: The Case of Xinjiang, China
Evaluation Method of Equalization of Basic Medical Services from the Spatial Perspective: The Case of Xinjiang, China Open
Protecting residents’ health and improving equality are important goals of the United Nations Sustainable Development Goals. The recent outbreak of COVID-19 has placed a heavy burden on the medical systems of many countries and been disast…
View article: Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence
Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence Open
Objectives Alcohol dependence accounts for a large proportion of the global burden of disease and disability. This study aims to investigate the candidate genes and chemicals associated with alcohol dependence. Methods Using data from publ…
View article: Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety
Assessing the interaction effects of brain structure longitudinal changes and life environmental factors on depression and anxiety Open
Disrupted brain structures and several life environmental factors have been shown to influence depression and anxiety, but their interactions with anxiety and depression remain elusive. Genome‐wide association study datasets of 15 brain st…
View article: A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms
A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms Open
Background Growing evidence supports that alterations in the gut microbiota play an essential role in the etiology of anxiety, depression, and other psychiatric disorders. However, the potential effect of oral microbiota on mental health h…
View article: The plasma membrane-localized OsNIP1;2 mediates internal aluminum detoxification in rice
The plasma membrane-localized OsNIP1;2 mediates internal aluminum detoxification in rice Open
Aluminum (Al) toxicity significantly restricts crop production on acidic soils. Although rice is highly resistant to Al stress, the underlying resistant mechanisms are not fully understood. Here, we characterized the function of OsNIP1;2, …
View article: Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder
Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder Open
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human…
View article: A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism
A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism Open
Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends on efficient protein renewal. This study aims to systematically analyze the association between anxiety / depression…
View article: Associations between IBS, IBD and the risk of Insomnia: An Observational Analysis and Genome-wide Interaction Study
Associations between IBS, IBD and the risk of Insomnia: An Observational Analysis and Genome-wide Interaction Study Open
Background: Irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) were reported to be associated with mental disorders. But limited efforts were made to investigate the relationship between IBS/IBD and the risk of insomnia, …
View article: The Causal Relationships Between Sleep-related Phenotypes and Body Composition: A Mendelian Randomized Study
The Causal Relationships Between Sleep-related Phenotypes and Body Composition: A Mendelian Randomized Study Open
Background Despite cumulative evidence showing obesity is associated with changes in sleep quality and quantity, the study about the relationships between sleep and body composition is scarce, and whether the relationship is causal remains…
View article: Cross Domain Few-Shot Learning via Meta Adversarial Training
Cross Domain Few-Shot Learning via Meta Adversarial Training Open
Few-shot relation classification (RC) is one of the critical problems in machine learning. Current research merely focuses on the set-ups that both training and testing are from the same domain. However, in practice, this assumption is not…
View article: The Genetic Structure of Pain in Depression Patients: A Genome-Wide Association Study and Proteome-Wide Association Study
The Genetic Structure of Pain in Depression Patients: A Genome-Wide Association Study and Proteome-Wide Association Study Open
Background Pain symptoms are common in the patients with depression. Comparing with the general population, the pain in depression patients has more complex biological mechanism. We aim to explore the etiological mechanism of pain in depre…
View article: Digital Intelligent Management Platform for High-Rise Building Construction Based on BIM Technology
Digital Intelligent Management Platform for High-Rise Building Construction Based on BIM Technology Open
In this study, the digital intelligent management platform of high-rise building construction based on BIM technology is used for real-time monitoring and management of construction progress and quality. In the data acquisition and process…
View article: Additional file 2 of A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism
Additional file 2 of A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism Open
Additional file 2. Correlation matrix among the covariates and neuroticism, anxiety, and depression score
View article: Additional file 3 of A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism
Additional file 3 of A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism Open
Additional file 3. Detailed results of effectiveness evaluation of protein PRS method in independent omics studies
View article: Genome-Wide Association Study and Genetic Correlation Scan Provide Insights into Its Genetic Architecture of Sleep Health Score in the UK Biobank Cohort
Genome-Wide Association Study and Genetic Correlation Scan Provide Insights into Its Genetic Architecture of Sleep Health Score in the UK Biobank Cohort Open
Yao Yao,* Yumeng Jia,* Yan Wen, Bolun Cheng, Shiqiang Cheng, Li Liu, Xuena Yang, Peilin Meng, Yujing Chen, Chun’e Li, Jingxi Zhang, Zhen Zhang, Chuyu Pan, Huijie Zhang, Cuiyan Wu, Xi Wang, Yujie Ning, Sen Wang, Feng Zhang Key Laboratory of…
View article: Integrative analysis of proteome-wide association and transcriptome-wide association study identifies candidate brain proteins associated with insomnia
Integrative analysis of proteome-wide association and transcriptome-wide association study identifies candidate brain proteins associated with insomnia Open
Great progress has been made in identifying risk loci for insomnia by genome-wide association studies (GWAS) analysis, but its association with human brain proteome is unclear. Two insomnia GWAS summary datasets were derived from deCODE (n…