Chung Tin
YOU?
Author Swipe
View article: Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities
Cerebellum-Targeted Transcranial Focused Ultrasound Stimulation Modulates Hippocampus Neural Activities Open
Low-intensity transcranial focused ultrasound stimulation (tFUS) has recently emerged as a promising neuromodulation technique due to its non-invasive nature, ability to penetrate deeply, and high spatial resolution. On the other hand, the…
View article: Impact of Body Image Perception on Behavioral Outcomes in Chinese Adolescent and Young Adult Survivors of Sarcoma
Impact of Body Image Perception on Behavioral Outcomes in Chinese Adolescent and Young Adult Survivors of Sarcoma Open
Purpose To identify the prevalence and predictive factors of body image dissatisfaction among Chinese adolescent and young adult (AYA) survivors of sarcoma and to evaluate its associations with behavioral outcomes. Methods In total, 116 AY…
View article: Extended replicative lifespan of primary resting T cells by CRISPR/dCas9-based epigenetic modifiers and transcriptional activators
Extended replicative lifespan of primary resting T cells by CRISPR/dCas9-based epigenetic modifiers and transcriptional activators Open
View article: Real‐time field‐programmable gate array‐based closed‐loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia
Real‐time field‐programmable gate array‐based closed‐loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia Open
Aims The open‐loop nature of conventional deep brain stimulation (DBS) produces continuous and excessive stimulation to patients which contributes largely to increased prevalence of adverse side effects. Cerebellar ataxia is characterized …
View article: Impact of Body Image Perception on Behavioral Outcomes in Chinese Adolescent and Young Adult Survivors of Sarcoma
Impact of Body Image Perception on Behavioral Outcomes in Chinese Adolescent and Young Adult Survivors of Sarcoma Open
Purpose To identify the prevalence and predictive factors of body image dissatisfaction among Chinese adolescent and young adult (AYA) survivors of sarcoma, and to evaluate its associations with behavioral outcomes. Methods In total, 116 A…
View article: Clinical, neuroimaging, and behavioural risk factors for neurocognitive impairment in Chinese patients with haemophilia: A multicentre study
Clinical, neuroimaging, and behavioural risk factors for neurocognitive impairment in Chinese patients with haemophilia: A multicentre study Open
Background Few studies have evaluated the impact of subclinical microstructural changes and psychosocial factors on cognitive function in patients with haemophilia. Objectives To determine the prevalence and characteristics of cognitive im…
View article: Effective and efficient neural networks for spike inference from in vivo calcium imaging
Effective and efficient neural networks for spike inference from in vivo calcium imaging Open
Calcium imaging provides advantages in monitoring large populations of neuronal activities simultaneously. However, it lacks the signal quality provided by neural spike recording in traditional electrophysiology. To address this issue, we …
View article: Positive feedback of efferent copy via pontine nucleus facilitates cerebellum-mediated associative learning
Positive feedback of efferent copy via pontine nucleus facilitates cerebellum-mediated associative learning Open
The cerebellum is critical for motor coordination and learning. However, the role of feedback circuitry in this brain region has not been fully explored. Here, we characterize a nucleo-ponto-cortical feedback pathway in classical delayed e…
View article: Associations between Lifestyle Factors and Neurocognitive Impairment among Chinese Adolescent and Young Adult (AYA) Survivors of Sarcoma
Associations between Lifestyle Factors and Neurocognitive Impairment among Chinese Adolescent and Young Adult (AYA) Survivors of Sarcoma Open
Background: The effect of lifestyle on neurocognitive impairment among cancer survivors remain an understudied area. This study explored the association between lifestyle factors and neurocognitive outcomes (specifically, attention, memory…
View article: Multimodal detection of flap endonuclease 1 activity through CRISPR/Cas12a trans-cleavage of single-strand DNA oligonucleotides
Multimodal detection of flap endonuclease 1 activity through CRISPR/Cas12a trans-cleavage of single-strand DNA oligonucleotides Open
View article: Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing
Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing Open
Itch is a cutaneous sensation that is critical in driving scratching behavior. The long-standing question of whether there are specific neurons for itch modulation inside the brain remains unanswered. Here, we report a subpopulation of itc…
View article: PAM-flexible dual base editor-mediated random mutagenesis and self-activation strategies to improve CRISPRa potency
PAM-flexible dual base editor-mediated random mutagenesis and self-activation strategies to improve CRISPRa potency Open
VP64 is the smallest transactivation domain that can be packaged together with the sgRNA into a single adeno-associated virus (AAV) vector. However, VP64-based CRISPRa often exerts modest activation to the target gene when only one sgRNA i…
View article: Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery
Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery Open
Compared with siRNAs or other antisense oligonucleotides (ASOs), the chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability of threose nucleic acid (TNA) motivate scien…
View article: Multimodal Detection of Flap Endonuclease 1 Activity Through Crispr/Cas12a Trans-Cleavage of Single-Strand DNA Oligonucleotides
Multimodal Detection of Flap Endonuclease 1 Activity Through Crispr/Cas12a Trans-Cleavage of Single-Strand DNA Oligonucleotides Open
View article: Effective and Efficient Neural Networks for Spike Inference from<i>In Vivo</i>Calcium Imaging
Effective and Efficient Neural Networks for Spike Inference from<i>In Vivo</i>Calcium Imaging Open
Calcium imaging technique provides the advantages in monitoring large population of neuronal activities simultaneously. However, it lacks the signal quality provided by neural spike recording in traditional electrophysiology. To address th…
View article: Awareness of diagnosis, treatment and risk of late effects in Chinese survivors of childhood cancer in Hong Kong
Awareness of diagnosis, treatment and risk of late effects in Chinese survivors of childhood cancer in Hong Kong Open
Background For survivors of childhood cancer, awareness of personal health risks is a critical component of long‐term health management. Objective To evaluate the awareness of the diagnosis, treatment and risk of late effects among survivo…
View article: Fully automatic electrocardiogram classification system based on generative adversarial network with auxiliary classifier
Fully automatic electrocardiogram classification system based on generative adversarial network with auxiliary classifier Open
View article: CRISPR-based strategies for targeted transgene knock-in and gene correction
CRISPR-based strategies for targeted transgene knock-in and gene correction Open
The last few years have seen tremendous advances in CRISPR-mediated genome editing. Great efforts have been made to improve the efficiency, specificity, editing window, and targeting scope of CRISPR/Cas9-mediated transgene knock-in and gen…
View article: A Nucleo-Ponto-Cortical Circuit Facilitates Cerebellum-Mediated Associative Learning Via Excitatory Feedback of Efference Copy
A Nucleo-Ponto-Cortical Circuit Facilitates Cerebellum-Mediated Associative Learning Via Excitatory Feedback of Efference Copy Open
View article: Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa
Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa Open
View article: A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification
A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification Open
Quantitative and dynamic analyses of immune cell secretory cytokines are essential for precise determination and characterization of the “immune phenotype” of patients for clinical diagnosis and treatment of immune-related diseases.
View article: Automated ECG Classification Using Dual Heartbeat Coupling Based on Convolutional Neural Network
Automated ECG Classification Using Dual Heartbeat Coupling Based on Convolutional Neural Network Open
A high performance electrocardiogram (ECG)-based arrhythmic beats classification system is presented in this paper. The classifier was designed based on convolutional neural network (CNN). Single channel ECG signal was segmented into heart…
View article: Self-Recalibrating Surface EMG Pattern Recognition for Neuroprosthesis Control Based on Convolutional Neural Network
Self-Recalibrating Surface EMG Pattern Recognition for Neuroprosthesis Control Based on Convolutional Neural Network Open
Hand movement classification based on surface electromyography (sEMG) pattern recognition is a promising approach for upper limb neuroprosthetic control. However, maintaining day-to-day performance is challenged by the non-stationary natur…
View article: Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury
Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury Open
View article: Real-Time Simulation of Passage-of-Time Encoding in Cerebellum Using a Scalable FPGA-Based System
Real-Time Simulation of Passage-of-Time Encoding in Cerebellum Using a Scalable FPGA-Based System Open
The cerebellum plays a critical role for sensorimotor control and learning. However, dysmetria or delays in movements' onsets consequent to damages in cerebellum cannot be cured completely at the moment. Neuroprosthesis is an emerging tech…
View article: Submissive hypercapnia: Why COPD patients are more prone to CO2 retention than heart failure patients
Submissive hypercapnia: Why COPD patients are more prone to CO2 retention than heart failure patients Open