Chunguang Guo
YOU?
Author Swipe
View article: A deep learning based automatic report generator for retinal optical coherence tomography images
A deep learning based automatic report generator for retinal optical coherence tomography images Open
Reading and summarizing insights from Optical Coherence Tomography (OCT) images is a routine yet time-consuming task that requires expensive time from experienced ophthalmologists. This paper introduces the Multi-label OCT Report Generatio…
View article: Transcriptomic elucidation of Dahuang-Huanglian in promoting white adipose browning in high-fat diet-induced obese rats
Transcriptomic elucidation of Dahuang-Huanglian in promoting white adipose browning in high-fat diet-induced obese rats Open
Objective Dahuang ( Rhei Radix et Rhizoma )-Huanglian ( Coptidis Rhizoma ) (DHHL), has been shown to effectively treat obesity caused by dietary irregularities. Nevertheless, the fundamental process driving this phenomenon has yet to be el…
View article: Bidirectional relationship between platelet count and skin cancer: tumor drug resistance mechanisms
Bidirectional relationship between platelet count and skin cancer: tumor drug resistance mechanisms Open
Our findings reveal a bidirectional, subtype-specific relationship between PLT and skin cancer. Elevated PLT levels specifically increase the risk of MSC, while MSC influences PLT count positively. In contrast, NMSC is associated with lowe…
View article: <scp>YBX1</scp> Modulates Intimal Hyperplasia by Regulating Expression and Alternative Splicing of Cell Cycle Associated Genes in <scp>RASMCs</scp>
<span>YBX1</span> Modulates Intimal Hyperplasia by Regulating Expression and Alternative Splicing of Cell Cycle Associated Genes in <span>RASMCs</span> Open
YBX1, a DNA‐/RNA‐binding protein, is implicated in various diseases, yet its role in intimal hyperplasia (IH) remains unclear. This study investigates YBX1's function in rat aortic smooth muscle cells (RASMCs) through knockdown experiments…
View article: Quantitative Analysis of Phosphorothioate Isomers in CRISPR sgRNA at Single-Residue Resolution Using Endonuclease Digestion Coupled with Liquid Chromatography Cyclic Ion Mobility Mass Spectrometry (LC/cIMS)
Quantitative Analysis of Phosphorothioate Isomers in CRISPR sgRNA at Single-Residue Resolution Using Endonuclease Digestion Coupled with Liquid Chromatography Cyclic Ion Mobility Mass Spectrometry (LC/cIMS) Open
Phosphorothioate (PS) modifications in single-guided RNA (sgRNA) are crucial for genome editing applications using the CRISPR/Cas9 system. These modifications may enhance sgRNA stability, pharmacokinetics, and binding to targets, thereby f…
View article: Research on the Evaluation Model of Automotive Talents Based on Factor Analysis Method
Research on the Evaluation Model of Automotive Talents Based on Factor Analysis Method Open
With the rapid development of the automotive industry, the demand for high-quality talents is increasing day by day. This article uses factor analysis method to construct an automotive talent evaluation model, aiming to help enterprises se…
View article: A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies Open
View article: Associations Between Cardiovascular Health (Life's Essential 8) and Mental Disorders
Associations Between Cardiovascular Health (Life's Essential 8) and Mental Disorders Open
Background Mental health was closely associated with cardiovascular disease (CVD). We aimed to investigate the association between cardiovascular health (CVH), as defined by Life's Essential 8 (LE8), and the presence of depression and anxi…
View article: Machine learning‐driven diagnostic signature provides new insights in clinical management of hypertrophic cardiomyopathy
Machine learning‐driven diagnostic signature provides new insights in clinical management of hypertrophic cardiomyopathy Open
Aims In an era of evolving diagnostic possibilities, existing diagnostic systems are not fully sufficient to promptly recognize patients with early‐stage hypertrophic cardiomyopathy (HCM) without symptomatic and instrumental features. Cons…
View article: Anti-S-layer monoclonal antibodies impact <i>Clostridioides difficile</i> physiology
Anti-S-layer monoclonal antibodies impact <i>Clostridioides difficile</i> physiology Open
Clostridioides difficile (C. difficile), a gram-positive anaerobic and spore-forming bacterium, is the leading cause of nosocomial antibiotic-associated diarrhea in adults which is characterized by high levels of recurrence a…
View article: A monoclonal antibody collection for C. difficile typing ?
A monoclonal antibody collection for C. difficile typing ? Open
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles…
View article: Associations Between Life's Essential 8 and Chronic Kidney Disease
Associations Between Life's Essential 8 and Chronic Kidney Disease Open
Background Chronic kidney disease (CKD) is closely associated with cardiovascular disease. We aimed to examine the association of Life's Essential 8 (LE8), the recently updated measurement of cardiovascular health, with the prevalence of C…
View article: BEST: a web application for comprehensive biomarker exploration on large-scale data in solid tumors
BEST: a web application for comprehensive biomarker exploration on large-scale data in solid tumors Open
Data mining from RNA-seq or microarray data has become an essential part of cancer biomarker exploration. Certain existing web servers are valuable and broadly utilized, but the meta-analysis of multiple datasets is absent. Most web server…
View article: Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma
Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma Open
Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI…
View article: Analysis of textbook outcomes for ampullary carcinoma patients following pancreaticoduodenectomy
Analysis of textbook outcomes for ampullary carcinoma patients following pancreaticoduodenectomy Open
Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI…
View article: A monoclonal antibody collection for<i>C. difficile</i>typing
A monoclonal antibody collection for<i>C. difficile</i>typing Open
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles…
View article: Anti-S-layer monoclonal antibodies impact<i>C. difficile</i>physiology
Anti-S-layer monoclonal antibodies impact<i>C. difficile</i>physiology Open
Clostridioides difficile ( C. difficile ), a gram-positive anaerobic and spore-forming bacterium, is the leading cause of nosocomial antibiotic-associated diarrhea in adults and is characterized by high levels of recurrence and mortality. …
View article: Equivalent Survival between Gastric Large-Cell Neuroendocrine Carcinoma and Gastric Small-Cell Neuroendocrine Carcinoma
Equivalent Survival between Gastric Large-Cell Neuroendocrine Carcinoma and Gastric Small-Cell Neuroendocrine Carcinoma Open
Background: According to the 2019 World Health Organization (WHO) classification of gastric neuroendocrine neoplasms, gastric neuroendocrine carcinoma (GNEC) can be further divided into gastric large-cell neuroendocrine carcinoma (GLNEC) a…
View article: Immune perturbation network identifies an EMT subtype with chromosomal instability and tumor immune-desert microenvironment
Immune perturbation network identifies an EMT subtype with chromosomal instability and tumor immune-desert microenvironment Open
View article: Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma
Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma Open
View article: CRISPR-Cas9 identifies growth-related subtypes of glioblastoma with therapeutical significance through cell line knockdown
CRISPR-Cas9 identifies growth-related subtypes of glioblastoma with therapeutical significance through cell line knockdown Open
Background Glioblastoma (GBM) is a type of highly malignant brain tumor that is known for its significant intratumoral heterogeneity, meaning that there can be a high degree of variability within the tumor tissue. Despite the identificatio…
View article: Impact of perioperative blood transfusion on oncological outcomes in ampullary carcinoma patients underwent pancreaticoduodenectomy
Impact of perioperative blood transfusion on oncological outcomes in ampullary carcinoma patients underwent pancreaticoduodenectomy Open
Obstructive jaundice (OJ) is a common problem in daily clinical practice. However, completely understanding the pathophysiological changes in OJ remains a challenge for planning current and future management. The effects of OJ are widespre…
View article: Immune‐related interaction perturbation networks unravel biological peculiars and clinical significance of glioblastoma
Immune‐related interaction perturbation networks unravel biological peculiars and clinical significance of glioblastoma Open
The immune system is an interacting network of plentiful molecules that could better characterize the relationship between immunity and cancer. This study aims to investigate the behavioral patterns of immune‐related interaction perturbati…
View article: Multi-center validation of an immune-related lncRNA signature for predicting survival and immune status of patients with renal cell carcinoma: an integrating machine learning-derived study
Multi-center validation of an immune-related lncRNA signature for predicting survival and immune status of patients with renal cell carcinoma: an integrating machine learning-derived study Open
View article: Laparoscopic endoscopic cooperative surgery for the duodenal neuroendocrine tumor: A single-center case series (How I Do It)
Laparoscopic endoscopic cooperative surgery for the duodenal neuroendocrine tumor: A single-center case series (How I Do It) Open
LECS with endoscopic full-thickness resection is a reliable surgical procedure. The minimally invasive advantages of LECS enable more individualized treatment options for a specific group. Limited by the length of observation, the long-ter…
View article: Immunosenescence: molecular mechanisms and diseases
Immunosenescence: molecular mechanisms and diseases Open
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence). During aging, organisms tend to develop …
View article: Comparative outcomes of anticoagulation alone versus anticoagulation plus endovascular intervention in adults with isolated renal vein thrombosis
Comparative outcomes of anticoagulation alone versus anticoagulation plus endovascular intervention in adults with isolated renal vein thrombosis Open
The etiologies of RVT can and should be investigated. In the present study, RVT was primarily caused by nephrotic syndrome in young patients and also was attributed to malignancy and lupus nephritis. In addition to anticoagulation therapy,…
View article: Data from Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis
Data from Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis Open
Purpose: This study aimed to identify novel biological markers for the prediction of colorectal cancer liver metastasis.Experimental Design: We established two models that mimicked the interactions between colorectal tumor ce…
View article: Supplementary Data from Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis
Supplementary Data from Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis Open
Supplementary Data from Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis
View article: Data from Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis
Data from Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis Open
Purpose: This study aimed to identify novel biological markers for the prediction of colorectal cancer liver metastasis.Experimental Design: We established two models that mimicked the interactions between colorectal tumor ce…