Chunheng Mo
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View article: Research progress on the application of nanoparticles delivery in the treatment of atherosclerosis: implications for therapeutic interventions
Research progress on the application of nanoparticles delivery in the treatment of atherosclerosis: implications for therapeutic interventions Open
Atherosclerosis (AS) is a chronic cardiovascular disease and a leading cause of global morbidity and mortality. Its pathological features include lipid accumulation within the arterial walls, macrophage infiltration, and the proliferation …
View article: Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies
Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies Open
Pneumoconiosis, caused by exposure to inorganic hazardous materials, is a highly prevalent and severe occupational disease. It is characterized by a progressive inflammatory process and the development of permanent lung fibrosis, which ult…
View article: Harnessing Artificial Intelligence for Accurate Diagnosis and Radiomics Analysis of Combined Pulmonary Fibrosis and Emphysema: Insights from a Multicenter Cohort Study
Harnessing Artificial Intelligence for Accurate Diagnosis and Radiomics Analysis of Combined Pulmonary Fibrosis and Emphysema: Insights from a Multicenter Cohort Study Open
Combined Pulmonary Fibrosis and Emphysema (CPFE), formally recognized as a distinct pulmonary syndrome in 2022, is characterized by unique clinical features and pathogenesis that may lead to respiratory failure and death. However, the diag…
View article: In vitro gastrin-releasing peptide response in chicken ovarian follicles
In vitro gastrin-releasing peptide response in chicken ovarian follicles Open
The gastrin-releasing peptide (GRP) is reported to be mainly produced by the pituitary in chickens, with its receptor (GRPR) highly expressed in the ovaries, indicating its regulatory role in ovarian function. Present study aims to verify …
View article: Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies (Adv. Sci. 11/2025)
Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies (Adv. Sci. 11/2025) Open
Transfusion‐Related Acute Lung Injury In this frontispiece, a transfusion bag, Taiji symbol, and alveolar structure highlight the immune imbalance triggered by exogenous blood products, resulting in acute lung injury. Article number 241336…
View article: Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies
Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies Open
Transfusion‐related acute lung injury (TRALI) is a potentially lethal complication of blood transfusions, characterized by the rapid onset of pulmonary edema and hypoxemia within six hours post‐transfusion. As one of the primary causes of …
View article: Harnessing Artificial Intelligence for Accurate Diagnosis and Radiomics Analysis of Combined Pulmonary Fibrosis and Emphysema: Insights from a Multicenter Cohort Study
Harnessing Artificial Intelligence for Accurate Diagnosis and Radiomics Analysis of Combined Pulmonary Fibrosis and Emphysema: Insights from a Multicenter Cohort Study Open
Combined Pulmonary Fibrosis and Emphysema (CPFE), formally recognized as a distinct pulmonary syndrome in 2022, is characterized by unique clinical features and pathogenesis that may lead to respiratory failure and death. However, the diag…
View article: SQSTM1 upregulation-induced iron overload triggers endothelial ferroptosis in nicotine-exacerbated atherosclerosis
SQSTM1 upregulation-induced iron overload triggers endothelial ferroptosis in nicotine-exacerbated atherosclerosis Open
This study has been registered in the Chinese Clinical Trial Registry (ChiCTR2400083484, Registration Date: April 26, 2024).
View article: Targeting mast cell activation alleviates anti-MHC I antibody and LPS-induced TRALI in mice by pharmacologically blocking the TLR3 and MAPK pathway
Targeting mast cell activation alleviates anti-MHC I antibody and LPS-induced TRALI in mice by pharmacologically blocking the TLR3 and MAPK pathway Open
Transfusion-related lung injury (TRALI) poses a significant risk following blood transfusion and remains the primary cause of transfusion-related morbidity and mortality, primarily driven by the activation of immune cells through anti-majo…
View article: Effect of IVIG therapy on pregnant women with unexplained recurrent spontaneous abortion: a systematic review and meta-analysis
Effect of IVIG therapy on pregnant women with unexplained recurrent spontaneous abortion: a systematic review and meta-analysis Open
Objective To assess the effect of intravenous immunoglobulin (IVIG) therapy on unexplained recurrent spontaneous abortion (URSA). Methods We retrieved all randomized controlled trials (RCTs) related to the effect of IVIG therapy on URSA in…
View article: Ferroptosis in chronic obstructive pulmonary disease: From cellular mechanisms to therapeutic applications
Ferroptosis in chronic obstructive pulmonary disease: From cellular mechanisms to therapeutic applications Open
To the Editor: Chronic obstructive pulmonary disease (COPD) is a global public health challenge without effective treatment currently available, affecting >300 million individuals worldwide. Comprehensively understanding the pathogenesis o…
View article: Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions
Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer f…
View article: Comprehensive review of potential drugs with anti-pulmonary fibrosis properties
Comprehensive review of potential drugs with anti-pulmonary fibrosis properties Open
Pulmonary fibrosis is a chronic and progressive lung disease characterized by the accumulation of scar tissue in the lungs, which leads to impaired lung function and reduced quality of life. The prognosis for idiopathic pulmonary fibrosis …
View article: Lung regeneration: diverse cell types and the therapeutic potential
Lung regeneration: diverse cell types and the therapeutic potential Open
Lung tissue has a certain regenerative ability and triggers repair procedures after injury. Under controllable conditions, lung tissue can restore normal structure and function. Disruptions in this process can lead to respiratory system fa…
View article: Editorial: Cellular and molecular mechanisms of lung regeneration, repair, and fibrosis
Editorial: Cellular and molecular mechanisms of lung regeneration, repair, and fibrosis Open
EDITORIAL article Front. Cell Dev. Biol., 08 January 2024Sec. Molecular and Cellular Pathology Volume 11 - 2023 | https://doi.org/10.3389/fcell.2023.1346875
View article: Single-cell RNA sequencing analysis of lung cells in COVID-19 patients with diabetes, hypertension, and comorbid diabetes-hypertension
Single-cell RNA sequencing analysis of lung cells in COVID-19 patients with diabetes, hypertension, and comorbid diabetes-hypertension Open
Background There is growing evidence that the lung is a target organ for injury in diabetes and hypertension. There are no studies on the status of the lungs, especially cellular subpopulations, and related functions in patients with diabe…
View article: Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data
Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data Open
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a significant challenge to medical professionals due to its increasing incidence and prevalence coupled with the limited understanding of its underlying…
View article: The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential
The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential Open
Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the excessive production of extracellular matrix and aberrant activation of fibroblast. While Pirfenidone and Nintedanib are FDA-approved drugs that can slow…
View article: Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial–Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis
Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial–Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis Open
Chronic liver diseases affect over a billion people worldwide and often lead to fibrosis. Nonalcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndromes, is characterized by liver fibrosis, and its path…
View article: Research progress on perioperative blood-brain barrier damage and its potential mechanism
Research progress on perioperative blood-brain barrier damage and its potential mechanism Open
The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins. During the perioperati…
View article: Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS
Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS Open
Vascular leakage and inflammation are pathological hallmarks of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Endothelial cells (ECs) serve as a semipermeable barrier and play a key role in disease progression. It is …
View article: Role of ferroptosis in pregnancy related diseases and its therapeutic potential
Role of ferroptosis in pregnancy related diseases and its therapeutic potential Open
Ferroptosis is a form of regulated cell death characterized by iron overload, overwhelming lipid peroxidation, and disruption of antioxidant systems. Emerging evidence suggests that ferroptosis is associated with pregnancy related diseases…
View article: Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis
Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis Open
Liver fibrosis is one main histological characteristic of nonalcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndromes with no approved therapies. The role of the gut microbiota in NASH pathogenesis h…
View article: Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor in Male Chickens
Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor in Male Chickens Open
In vertebrates, adrenocorticotropin (ACTH), released by the pituitary gland, is a critical part of the stress axis and stress response. Generally, the biosynthesis and secretion of ACTH are controlled by both hypothalamic stimulatory facto…
View article: Single-Cell RNA Sequencing Analysis of Chicken Anterior Pituitary: A Bird’s-Eye View on Vertebrate Pituitary
Single-Cell RNA Sequencing Analysis of Chicken Anterior Pituitary: A Bird’s-Eye View on Vertebrate Pituitary Open
It is well-established that anterior pituitary contains multiple endocrine cell populations, and each of them can secrete one/two hormone(s) to regulate vital physiological processes of vertebrates. However, the gene expression profiles of…