Chao Luo
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View article: Type VII secretion system deploys an active iron uptake pathway to enhance bacterial fitness and counteract host nutritional immunity
Type VII secretion system deploys an active iron uptake pathway to enhance bacterial fitness and counteract host nutritional immunity Open
Type VII secretion systems (T7SS) are increasingly recognized as pivotal for bacterial adaptation across both environmental and host-associated niches in Gram-positive bacteria. Although T7SS has been reported to contribute to iron acquisi…
View article: Novel genetic algorithm‐based individual treatment effect scoring model for optimizing decision‐making: Induction chemotherapy in nasopharyngeal carcinoma
Novel genetic algorithm‐based individual treatment effect scoring model for optimizing decision‐making: Induction chemotherapy in nasopharyngeal carcinoma Open
Traditional decision‐making models often focus on risk prediction rather than treatment effects, potentially leading to suboptimal outcomes. This study developed an individual treatment effect (ITE) model to predict the survival benefit of…
View article: Clinical features and laboratory indicators of dengue infection in China: a retrospective study of adult patients in a hospital of traditional Chinese medicine
Clinical features and laboratory indicators of dengue infection in China: a retrospective study of adult patients in a hospital of traditional Chinese medicine Open
Background Dengue is an arboviral disease caused by the dengue virus, primarily transmitted by mosquitoes in tropical and subtropical regions. Despite preventive measures, the incidence and mortality of dengue remain significant. While the…
View article: Choroid Plexus Carcinoma in an Adult: Genetic Insights from a Unique Case Study
Choroid Plexus Carcinoma in an Adult: Genetic Insights from a Unique Case Study Open
Objective To investigate a rare adult case of choroid plexus carcinoma (CPC), with a focus on identifying genetic variations and their implications for prognosis and treatment selection. Methods The patient was diagnosed with Magnetic Reso…
View article: Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead
Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead Open
Review Exploring Fungi Within the Human Gut Microbiota: Obstacles, Innovations, Therapeutic Applications and Prospects Ahead Peng Xue 1,†, Chao Luo 2,†, Jiashu Li 3, Liang Yang 3,* and Yuanyuan Ma 1,* 1 Nantong Key Laboratory of Environmen…
View article: Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder
Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder Open
Addressing the escalating global burdens of inflammatory bowel disease and antimicrobial resistance demanded innovative food-based approaches to fortify gut health and suppress pathogens. We introduced a novel edible probiotic, Enterococcu…
View article: Geomechanical method for wellbore stability prediction: A case study of the Longmaxi formation in the Yongchuan shale gas field, southwestern China
Geomechanical method for wellbore stability prediction: A case study of the Longmaxi formation in the Yongchuan shale gas field, southwestern China Open
Shale formations display heterogeneous characteristics, and the current methods for assessing the stability of adjacent wells using drilling data have limitations. This paper presents a regional wellbore stability prediction method for sha…
View article: The Scoring Model to Predict ICU Stay and Mortality After Emergency Admissions in Atrial Fibrillation: A Retrospective Study of 30 366 Patients
The Scoring Model to Predict ICU Stay and Mortality After Emergency Admissions in Atrial Fibrillation: A Retrospective Study of 30 366 Patients Open
Background The rapid assessment of the conditions is crucial for the prognosis of atrial fibrillation (AF) patients admitted to the emergency department (ED). We aim to derive and validate a more accurate and simplified scoring model to op…
View article: Prognostic Value of Skull Base Foramen Invasion Subclassification in T Category Modification and Induction Chemotherapy Management for Nasopharyngeal Carcinoma: Post‐Hoc Analysis of a Dual‐Center Retrospective Cohort Study
Prognostic Value of Skull Base Foramen Invasion Subclassification in T Category Modification and Induction Chemotherapy Management for Nasopharyngeal Carcinoma: Post‐Hoc Analysis of a Dual‐Center Retrospective Cohort Study Open
Skull base foramen invasion (SBFI) indicates poor prognosis in nasopharyngeal carcinoma (NPC). However, only a few studies systematically assessed the role of SBFIin staging and treatment of NPC. To investigate the prognostic value of SBFI…
View article: Guiding induction chemotherapy of locoregionally advanced nasopharyngeal carcinoma with ternary classification of predicted individual treatment effect
Guiding induction chemotherapy of locoregionally advanced nasopharyngeal carcinoma with ternary classification of predicted individual treatment effect Open
The ternary PITE classification offers an accurate and clinically advantageous approach to guide personalized IC decision-making in patients with LANPC.
View article: Radiomics-based lymph nodes prognostic models from three MRI regions in nasopharyngeal carcinoma
Radiomics-based lymph nodes prognostic models from three MRI regions in nasopharyngeal carcinoma Open
Accurate prediction of the prognosis of nasopharyngeal carcinoma (NPC) is important for treatment. Lymph nodes metastasis is an important predictor for distant failure and regional recurrence in patients with NPC. Traditionally, subjective…
View article: Value of radiological depth of invasion in non-pT4 Oral tongue squamous cell carcinoma: implication for preoperative MR T-staging
Value of radiological depth of invasion in non-pT4 Oral tongue squamous cell carcinoma: implication for preoperative MR T-staging Open
Objective The prognostic stratification for oral tongue squamous cell carcinoma (OTSCC) is heavily based on postoperative pathological depth of invasion (pDOI). This study aims to propose a preoperative MR T-staging system based on tumor s…
View article: A Rulefit-based prognostic analysis using structured MRI report to select potential beneficiaries from induction chemotherapy in advanced nasopharyngeal carcinoma: A dual-centre study
A Rulefit-based prognostic analysis using structured MRI report to select potential beneficiaries from induction chemotherapy in advanced nasopharyngeal carcinoma: A dual-centre study Open
The Rulefit-based Rules model, with the revelation of intrinsic associations behind structured variables, is promising in risk stratification and guiding individualised IC treatment for advanced NPC.
View article: Synergistic Association of Hepatitis B Surface Antigen and Plasma Epstein-Barr Virus DNA Load on Distant Metastasis in Patients With Nasopharyngeal Carcinoma
Synergistic Association of Hepatitis B Surface Antigen and Plasma Epstein-Barr Virus DNA Load on Distant Metastasis in Patients With Nasopharyngeal Carcinoma Open
Importance Hepatitis B surface antigen (HBsAg) reportedly increases the risk of distant metastasis among patients with nasopharyngeal carcinoma (NPC). However, the associated potential interaction and changes in hazard ratios (HRs) between…
View article: Prognostic value of MR-detected mandibular nerve involvement: potential indication for future individual induction chemotherapy in T4 nasopharyngeal carcinoma
Prognostic value of MR-detected mandibular nerve involvement: potential indication for future individual induction chemotherapy in T4 nasopharyngeal carcinoma Open
Purpose To investigate the prognostic significance of MR-detected mandibular nerve involvement (MNI) and its value for induction chemotherapy (IC) administration in patients with nasopharyngeal carcinoma (NPC) and T4 disease. Methods This …
View article: Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation
Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation Open
Backgrounds Trimodal therapy (neoadjuvant chemoradiotherapy followed by esophagectomy) for locally advanced esophageal squamous cell carcinoma (ESCC) is associated with a significant survival benefit. Modified Ryan score is an effective to…
View article: Clinical outcomes of pipeline embolization devices with shield technology for treating intracranial aneurysms
Clinical outcomes of pipeline embolization devices with shield technology for treating intracranial aneurysms Open
Introduction As a common endovascular treatment for intracranial aneurysms, the pipeline embolization device (PED) is considered a standard treatment option, especially for large, giant, wide-necked, or dissecting aneurysms. A layer of pho…
View article: Enteral nutrition improves the prognosis and immune nutritional status of patients in the cardiothoracic surgery recovery unit: A propensity score–matched analysis
Enteral nutrition improves the prognosis and immune nutritional status of patients in the cardiothoracic surgery recovery unit: A propensity score–matched analysis Open
EN may improve the prognosis and immune nutritional status of patients in the CSRU. Patients who might benefit should be actively treated with EN.
View article: Pan-Cancer Analysis and Experimental Validation Identify ACOT7 as a Novel Oncogene and Potential Therapeutic Target in Lung Adenocarcinoma
Pan-Cancer Analysis and Experimental Validation Identify ACOT7 as a Novel Oncogene and Potential Therapeutic Target in Lung Adenocarcinoma Open
Background: Acyl-CoA thioesterase 7 (ACOT7) is of great significance in regulating cell cycle, cell proliferation, and glucose metabolism. The function of ACOT7 in pan-cancer and its capacity as a prognostic indicator in lung adenocarcinom…
View article: RuleFit-Based Nomogram Using Inflammatory Indicators for Predicting Survival in Nasopharyngeal Carcinoma, a Bi-Center Study
RuleFit-Based Nomogram Using Inflammatory Indicators for Predicting Survival in Nasopharyngeal Carcinoma, a Bi-Center Study Open
The proposed final models based on inflammation-related rules based on RuleFit showed significantly elevated predictive performance.
View article: Home enteral nutrition for patients with esophageal cancer undergoing esophagectomy: A systematic review and meta-analysis
Home enteral nutrition for patients with esophageal cancer undergoing esophagectomy: A systematic review and meta-analysis Open
Introduction Home enteral nutrition (HEN) is a relatively new nutritional intervention that provides patients with EN support at home through jejunostomy or nasogastric feeding tubes. We conducted this systematic review and meta-analysis t…
View article: NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats Open
Background The transplantation of adipose-derived stem cells (ASCs) is a most promising treatment for diabetic erectile dysfunction (DMED). However, the effect of high glucose on the post-transplantation survival of stem cells limits the e…