Chunjian Li
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View article: Multi-Objective Optimization Study on the Separation Stability of the Falling Body in Absolute Gravimeters
Multi-Objective Optimization Study on the Separation Stability of the Falling Body in Absolute Gravimeters Open
The stability of absolute gravimeters during carriage-falling body separation is crucial for improving gravitational acceleration measurement accuracy. Transmission speed accuracy of the transmission system and system vibration are core fa…
View article: Non-conventional lipid parameters predict the risk of rapid kidney function decline in patients with cardiovascular-kidney-metabolic syndrome: The first cohort study evidence from CHARLS
Non-conventional lipid parameters predict the risk of rapid kidney function decline in patients with cardiovascular-kidney-metabolic syndrome: The first cohort study evidence from CHARLS Open
Background: This study evaluates the predictive value of three novel lipid-derived biomarkers: non-HDL-to-HDL cholesterol ratio (NHHR); natural logarithm of remnant cholesterol (lnRC); and cholesterol, high-density lipoprotein, and glucose…
View article: Emerging Elastic Micro-Nano Materials for Diagnosis and Treatment of Thrombosis
Emerging Elastic Micro-Nano Materials for Diagnosis and Treatment of Thrombosis Open
Thrombus is a blood clot that forms in a blood vessel at the point of flaking. Thrombosis is closely associated with cardiovascular diseases caused by different sources and factors. However, the current clinical methods of thrombus diagnos…
View article: One-year outcomes of a single bolus r-SAK before primary PCI for STEMI: Follow-up of the OPTIMA-5 study
One-year outcomes of a single bolus r-SAK before primary PCI for STEMI: Follow-up of the OPTIMA-5 study Open
The OPTIMA-5 study demonstrated that a single bolus of half-dose recombinant staphylokinase (r-SAK) before primary percutaneous coronary intervention (PCI) significantly improved the patency of infarct related artery in patients with ST-el…
View article: Using higher cut-off values to diagnose acute myocardial infarction in patients with elevated hs-cTnT
Using higher cut-off values to diagnose acute myocardial infarction in patients with elevated hs-cTnT Open
It is often challenging to diagnose acute myocardial infarction (AMI) in patients with elevated high-sensitivity cardiac troponin T (hs-cTnT) before a significant rise and/or fall of hs-cTnT can be observed. This study aimed to find an opt…
View article: Joint and interactive associations of body mass index and genetic factors with cardiovascular disease: a prospective study in UK Biobank
Joint and interactive associations of body mass index and genetic factors with cardiovascular disease: a prospective study in UK Biobank Open
BMI and genetic factors jointly and interactively contribute to incident CVD, especially among participants with high genetic risk. These findings have public health implications for identifying populations more likely to have cardiovascul…
View article: A reconstruction method for harmonic measurement in distribution networks based on equivalent harmonic source approach
A reconstruction method for harmonic measurement in distribution networks based on equivalent harmonic source approach Open
In recent years, with a large number of nonlinear devices connected to the distribution network, harmonic problems have been inevitably generated during operation, which makes harmonic problems more complex in the distribution network. How…
View article: Vitamin drinks improve palatability and reduce adverse events associated to polyethylene glycol electrolyte solutions
Vitamin drinks improve palatability and reduce adverse events associated to polyethylene glycol electrolyte solutions Open
Compared to the conventional 4L PEG bowel preparation, the use of a vitamin drink (Mizone) as an adjuvant can improve the palatability, reduce adverse events, and increase the patient's willingness to undergo bowel preparation with the sam…
View article: Extended Clopidogrel Monotherapy vs DAPT in Patients With Acute Coronary Syndromes at High Ischemic and Bleeding Risk
Extended Clopidogrel Monotherapy vs DAPT in Patients With Acute Coronary Syndromes at High Ischemic and Bleeding Risk Open
Importance Purinergic receptor P2Y12 (P2Y12) inhibitor monotherapy after a certain period of dual antiplatelet therapy (DAPT) may be an attractive option of maintenance antiplatelet treatment for patients undergoing percutaneous coronary i…
View article: Impact of hemodialysis on efficacies of the antiplatelet agents in coronary artery disease patients complicated with end-stage renal disease
Impact of hemodialysis on efficacies of the antiplatelet agents in coronary artery disease patients complicated with end-stage renal disease Open
It is controversial whether hemodialysis affects the efficacy of the antiplatelet agents. We aimed to investigate the impact of hemodialysis on efficacies of the antiplatelet agents in coronary artery disease (CAD) patients complicated wit…
View article: Efficient biosynthesis of creatine by whole-cell catalysis from guanidinoacetic acid in Corynebacterium glutamicum
Efficient biosynthesis of creatine by whole-cell catalysis from guanidinoacetic acid in Corynebacterium glutamicum Open
View article: Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes
Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes Open
Vascular calcification (VC) is a known predictor of cardiovascular events in patients with atherosclerosis and chronic renal disease. However, the exact relationship between VC and cardiovascular mortality remains unclear. Herein, we inves…
View article: 3D fusion between SPECT myocardial perfusion imaging and invasive coronary angiography to guide the treatment for patients with stable CAD
3D fusion between SPECT myocardial perfusion imaging and invasive coronary angiography to guide the treatment for patients with stable CAD Open
Objective We evaluated the value of three-dimensional (3D) fusion of SPECT myocardial perfusion imaging (MPI) with invasive coronary angiography (ICA) to guide coronary revascularization for patients with stable coronary artery disease (CA…
View article: Low RBC counts predict high on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention and treated with clopidogrel
Low RBC counts predict high on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention and treated with clopidogrel Open
View article: Impact of Hemodialysis on Efficacies of the Antiplatelet Agents in Coronary Artery Disease Patients Complicated with End‑Stage Renal Disease
Impact of Hemodialysis on Efficacies of the Antiplatelet Agents in Coronary Artery Disease Patients Complicated with End‑Stage Renal Disease Open
Background It is controversial whether hemodialysis affects the efficacy of the antiplatelet agents. We aimed to investigate the impact of hemodialysis on efficacies of the antiplatelet agents in coronary artery disease (CAD) patients comp…
View article: Rationale and design of the optimal antithrombotic treatment for acute coronary syndrome patients with concomitant atrial fibrillation and implanted with new‐generation drug‐eluting stent: OPtimal management of anTIthroMbotic Agents (OPTIMA)‐4 trial
Rationale and design of the optimal antithrombotic treatment for acute coronary syndrome patients with concomitant atrial fibrillation and implanted with new‐generation drug‐eluting stent: OPtimal management of anTIthroMbotic Agents (OPTIMA)‐4 trial Open
Background About 5%–15% of acute coronary syndrome (ACS) patients undergoing stent implantation have concomitant atrial fibrillation and need both antiplatelet and anticoagulant therapies. The optimal antithrombotic regimen remains uncerta…
View article: Optimal Mono Antiplatelet Therapy for Patients Implanted with Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis
Optimal Mono Antiplatelet Therapy for Patients Implanted with Drug-Eluting Stents: A Systematic Review and Network Meta-Analysis Open
View article: Interleukin‐29 Accelerates Vascular Calcification via JAK2/STAT3/BMP2 Signaling
Interleukin‐29 Accelerates Vascular Calcification via JAK2/STAT3/BMP2 Signaling Open
Background Vascular calcification (VC), associated with enhanced cardiovascular morbidity and mortality, is characterized by the osteogenic transdifferentiation of vascular smooth muscle cells. Inflammation promotes VC initiation and progr…
View article: Stumpless lesion improves the value of J-CTO score in predicting the antegrade procedure outcome of chronic total occlusion percutaneous coronary intervention
Stumpless lesion improves the value of J-CTO score in predicting the antegrade procedure outcome of chronic total occlusion percutaneous coronary intervention Open
Background Percutaneous coronary intervention (PCI) of coronary chronic total occlusion (CTO) is one of the most challenging procedures of interventional cardiology. Debate continues with regard to the predictors that influence the antegra…
View article: Effects of ilaprazole on the steady-state pharmacodynamics of clopidogrel in healthy volunteers: An open-label randomized crossover study
Effects of ilaprazole on the steady-state pharmacodynamics of clopidogrel in healthy volunteers: An open-label randomized crossover study Open
Background: Previous studies have suggested that proton pump inhibitors could impair the antiplatelet effect of clopidogrel. It is uncertain whether ilaprazole affects the antiplatelet effect of clopidogrel. This study aimed to determine t…
View article: Impact of Insulin Receptor Substrate‐1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention
Impact of Insulin Receptor Substrate‐1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention Open
Background Insulin receptor substrate‐1 ( IRS‐1 ) rs956115 is associated with vascular risk in patients with coronary artery disease and concomitant diabetes. CYP2C19*2 (rs4244285) modulates clopidogrel response and predicts the outcome of…
View article: Association of serum creatinine with aortic arch calcification in middle-aged and elderly adults: an observational cross-sectional study from China
Association of serum creatinine with aortic arch calcification in middle-aged and elderly adults: an observational cross-sectional study from China Open
View article: Predictive Value of Globulin to Prealbumin Ratio for 3-Month Functional Outcomes in Acute Ischemic Stroke Patients
Predictive Value of Globulin to Prealbumin Ratio for 3-Month Functional Outcomes in Acute Ischemic Stroke Patients Open
Objective. We aimed to evaluate and compare the association between globulin to albumin ratio (GAR) and globulin to prealbumin ratio (GPR) and 3-month functional prognosis of acute ischemic stroke (AIS) patients receiving intravenous throm…
View article: Simultaneous determination of clopidogrel, 2-oxo-clopidogrel, and the thiol metabolite of clopidogrel in human plasma by LC-MS/MS
Simultaneous determination of clopidogrel, 2-oxo-clopidogrel, and the thiol metabolite of clopidogrel in human plasma by LC-MS/MS Open
Clopidogrel is a pro-drug which needs two-step metabolism to produce the active thiol metabolite. This study aimed to explore an efficient method to simultaneously determine the plasma clopidogrel, 2-oxo-clopidogrel (2-Oxo-CLP), and the cl…
View article: Use of handheld electrocardiograph (SnapECG) for the remote monitoring of arrhythmias
Use of handheld electrocardiograph (SnapECG) for the remote monitoring of arrhythmias Open
Objective To investigate the value of a SnapECG monitoring in diagnosing arrhythmias compared with the conventional management. Methods In the first phase, the SnapECG and 12-lead electrocardiogram (ECG) were simultaneously adopted to dete…
View article: Impact of IRS-1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing PCI
Impact of IRS-1 rs956115 and CYP2C19 rs4244285 Genotypes on Clinical Outcome of Patients Undergoing PCI Open
Background insulin receptor substrate-1 (IRS-1) rs956115 is associated with vascular risk in patients with coronary artery disease (CAD) and concomitant diabetes. CYP2C19 rs4244285 modulates clopidogrel responsiveness and predicts outcome …
View article: An optimal window of platelet reactivity by LTA assay for patients undergoing percutaneous coronary intervention
An optimal window of platelet reactivity by LTA assay for patients undergoing percutaneous coronary intervention Open
View article: Intensified antiplatelet therapy in patients after percutaneous coronary intervention with high on‐treatment platelet reactivity: the OPTImal Management of Antithrombotic Agents (OPTIMA)‐2 Trial
Intensified antiplatelet therapy in patients after percutaneous coronary intervention with high on‐treatment platelet reactivity: the OPTImal Management of Antithrombotic Agents (OPTIMA)‐2 Trial Open
Summary High on‐treatment platelet reactivity (HOPR) is associated with increased risk of cardiovascular events in patients undergoing percutaneous coronary intervention (PCI). We randomised post‐PCI patients with HOPR after 5 days of stan…
View article: An Optimal Window of Platelet Reactivity by LTA Assay for Patients Undergoing Percutaneous Coronary Intervention
An Optimal Window of Platelet Reactivity by LTA Assay for Patients Undergoing Percutaneous Coronary Intervention Open
Objective This study was aimed to investigate an optimal therapeutic window for platelet reactivity (PR) to predict the lowest ischemic and bleeding events in patients underwent percutaneous coronary intervention (PCI) and treated with dua…
View article: Joint effect of platelet distribution width and stent surface area on major adverse cardiovascular events after percutaneous coronary intervention
Joint effect of platelet distribution width and stent surface area on major adverse cardiovascular events after percutaneous coronary intervention Open
Our present results suggest that the joint effect of PDW and SSA was significantly correlated to MACE development in the patients treated with PCI (with DES implantation).