Cheng Zhan
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View article: Cover Image, Volume 45, Issue 11
Cover Image, Volume 45, Issue 11 Open
The cover image is based on the article CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer by Jiaqi Liang et al., https://doi.org/10.1002/cac2.70068 . image
View article: CircZFR functions in cancer from molecular networks to precision therapy
CircZFR functions in cancer from molecular networks to precision therapy Open
CircRNAs are a class of covalently closed circular non-coding RNAs formed through back-splicing of precursor mRNAs, lacking 5′ caps and 3′ poly(A) tails, and are widely present in eukaryotic cells. Advances in high-throughput sequencing ha…
View article: CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer
CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer Open
Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiat…
View article: Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity
Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of motor neurons, muscle atrophy, and systemic energy imbalance. Increasing evidence suggests a metabolic shift in ALS from glu…
View article: Genome-Wide Identification, Characterization, and Comparison of C3HC4 Family Genes in Salt Tolerance Between Barley and Rice
Genome-Wide Identification, Characterization, and Comparison of C3HC4 Family Genes in Salt Tolerance Between Barley and Rice Open
Soil salinization constitutes a major constraint on global agricultural production, with marked divergence in salt adaptation strategies between salt-tolerant barley (Hordeum vulgare) and salt-sensitive rice (Oryza sativa). This study syst…
View article: Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction Open
The metastasis of lung cancer represents a significant factor contributing to the failure of clinical treatment, and the mechanisms involved are intricate and not yet completely elucidated. Intermediate filaments, which constitute a key el…
View article: KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma
KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma Open
Our study reveals that KLF13 promotes ferroptosis in LUAD by inhibiting GPX4, thereby enhancing sensitivity to chemotherapy drugs. Overall, targeting KLF13 may contribute to developing new therapeutic strategies for LUAD.
View article: ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis
ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis Open
Background Lung adenocarcinoma (LUAD) remains a significant contributor to cancer incidence and mortality, with transcription factors playing pivotal roles in its progression and serving as potential therapeutic targets. Results Through an…
View article: Sarcosine sensitizes lung adenocarcinoma to chemotherapy by dual activation of ferroptosis via PDK4/PDHA1 signaling and NMDAR-mediated iron export
Sarcosine sensitizes lung adenocarcinoma to chemotherapy by dual activation of ferroptosis via PDK4/PDHA1 signaling and NMDAR-mediated iron export Open
Background Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, is associated with chemoresistance in lung adenocarcinoma (LUAD). This study aims to investigate the role of sarcosine in ferroptosis and its under…
View article: Blood lipid metabolic biomarkers are emerging as significant prognostic indicators for survival in cancer patients
Blood lipid metabolic biomarkers are emerging as significant prognostic indicators for survival in cancer patients Open
Blood lipids, particularly HDL-C, TC, and ApoA1, emerge as accessible and cost-effective biomarkers that may aid in assessing survival outcomes in cancer patients and potentially inform clinical decision-making.
View article: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Chemotherapy is widely used to treat lung adenocarcinoma (LUAD) patients comprehensively. Considering the limitations of chemotherapy due to drug resistance and other issues, it is crucial to explore the impact of chemotherapy and immunoth…
View article: Vertical bearing performance of a concrete-filled steel tubular single pile and pile group in sand-rock composite ground
Vertical bearing performance of a concrete-filled steel tubular single pile and pile group in sand-rock composite ground Open
The seabed in the Fujian Sea Area is a soil-rock composite ground that limits the application of steel pipe piles in offshore wind power foundations. Therefore, a new type of concrete-filled steel tubular pile was proposed. However, the ve…
View article: Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing Open
Background Chemotherapy is widely used to treat lung adenocarcinoma (LUAD) patients comprehensively. Considering the limitations of chemotherapy due to drug resistance and other issues, it is crucial to explore the impact of chemotherapy a…
View article: Nuclear epidermal growth factor receptor (nEGFR) in clinical treatment
Nuclear epidermal growth factor receptor (nEGFR) in clinical treatment Open
The epidermal growth factor receptor (EGFR) is a recognized target in tumor treatment. While there is significant focus on inhibiting membrane EGFR and its downstream signaling activation, the ectopic accumulation of EGFR, particularly nuc…
View article: Gram-Negative Microflora Dysbiosis Facilitates Tumor Progression and Immune Evasion by Activating the CCL3/CCL5–CCR1–MAPK–PD-L1 Pathway in Esophageal Squamous Cell Carcinoma
Gram-Negative Microflora Dysbiosis Facilitates Tumor Progression and Immune Evasion by Activating the CCL3/CCL5–CCR1–MAPK–PD-L1 Pathway in Esophageal Squamous Cell Carcinoma Open
Gram-negative (G−) microflora dysbiosis occurs in multiple digestive tumors and is found to be the dominant microflora in the esophageal squamous cell carcinoma (ESCC) microenvironment. The continuous stimulation of G− bacterium metabolite…
View article: Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis
Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis Open
KRAS is among the most commonly mutated oncogenes in human malignancies. Although the advent of sotorasib and adagrasib, has lifted the "undruggable" stigma of KRAS, the resistance to KRAS inhibitors quickly becomes a major issue. Here, we…
View article: Supplementary Figure 3 from Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells
Supplementary Figure 3 from Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells Open
RETSAT does not interfere with known ferroptosis regulators.