Chunling Zhao
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View article: Natural Frequency Optimization of Stiffener Structure for Ceramic Matrix Composites Combustion Liner in Aero-Engines
Natural Frequency Optimization of Stiffener Structure for Ceramic Matrix Composites Combustion Liner in Aero-Engines Open
To mitigate vibration in thin-walled composite combustion liners of aero-engines, this study proposes an optimization strategy for stiffener design to maximize natural frequencies and suppress resonance. The approach enhances structural dy…
View article: Crystal Plasticity Modeling of Mechanical Anisotropy for TiAl Alloy Under Uniaxial and Biaxial Loading
Crystal Plasticity Modeling of Mechanical Anisotropy for TiAl Alloy Under Uniaxial and Biaxial Loading Open
TiAl alloys are widely used in aerospace applications due to their low density and good mechanical properties. However, their pronounced mechanical anisotropy resulting from the preferred orientations of lamellar crystals remains an import…
View article: Mapping the BCSC-1 interactome in breast cancer
Mapping the BCSC-1 interactome in breast cancer Open
BCSC-1 (breast cancer suppressor candidate-1), the official gene symbol VWA5A (von Willebrand factor A domain containing 5 A), is downregulated in a variety of cancer types including breast cancer. The role of BCSC-1 in tumorigenesis and t…
View article: Beyond energy: Mitochondrial control of platelet lifecycle through redox, calcium, and dynamics
Beyond energy: Mitochondrial control of platelet lifecycle through redox, calcium, and dynamics Open
View article: Microvoids Enhance the Low-Cycle Fatigue Resistance of TiAl Alloys
Microvoids Enhance the Low-Cycle Fatigue Resistance of TiAl Alloys Open
Voids have a crucial effect on the fatigue performance of materials. The general viewpoint is that voids, as possible sources of cracks, are harmful to the fatigue performance of materials. However, this study finds that microvoids enhance…
View article: Simple and Sensitive <i>Escherichia coli</i> Analysis <i>via</i> Allosteric Probe Controllable Switch Cas12a/crRNA Complex Mediated Strategy
Simple and Sensitive <i>Escherichia coli</i> Analysis <i>via</i> Allosteric Probe Controllable Switch Cas12a/crRNA Complex Mediated Strategy Open
The development of an innovative, portable, and cost-effective biosensor for rapid and accurate bacterial detection represents a significant advancement over conventional methods, offering a promising diagnostic tool for infection control …
View article: QuarkMed Medical Foundation Model Technical Report
QuarkMed Medical Foundation Model Technical Report Open
Recent advancements in large language models have significantly accelerated their adoption in healthcare applications, including AI-powered medical consultations, diagnostic report assistance, and medical search tools. However, medical tas…
View article: Circulating CHI3L1 autoantibodies serve as a diagnostic biomarker in patients with obstructive sleep apnea
Circulating CHI3L1 autoantibodies serve as a diagnostic biomarker in patients with obstructive sleep apnea Open
View article: AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition
AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition Open
Debate regarding the premature aging of knee joints in acquired immune deficiency syndrome (AIDS) patients has remained contentious, with conjectures pointing towards its correlation with distinct antiviral regimes. Protease inhibitors (PI…
View article: POS0998 CC312, A CD19-TARGETING, CO-STIMULATORY CD28 RECEPTOR-ACTIVATING TRI-SPECIFIC T CELL ENGAGER, FOR THE TREATMENT OF AUTOIMMUNE DISEASES
POS0998 CC312, A CD19-TARGETING, CO-STIMULATORY CD28 RECEPTOR-ACTIVATING TRI-SPECIFIC T CELL ENGAGER, FOR THE TREATMENT OF AUTOIMMUNE DISEASES Open
View article: Epigenetic roles of chromatin remodeling complexes in bone biology and the pathogenesis of bone‑related disease (Review)
Epigenetic roles of chromatin remodeling complexes in bone biology and the pathogenesis of bone‑related disease (Review) Open
Chromatin remodeling complexes are essential regulators of chromatin architecture, facilitating critical processes such as nucleosome sliding, eviction, histone exchange and post‑translational modifications. By providing an additional laye…
View article: Analysis of the influence of two kinds of shell characteristics on the total weight and soft tissue weight of the clam <i>Cyclina sinensis</i>
Analysis of the influence of two kinds of shell characteristics on the total weight and soft tissue weight of the clam <i>Cyclina sinensis</i> Open
To reveal the influence of shell traits between two shell colors on the body and soft tissue weight of the clam Cyclina sinensis , a total of 1000 individuals (500 with white shells and 500 with purple shells) were randomly selected to ana…
View article: Mitigating microplastic-induced organ Damage: Mechanistic insights from the microplastic-macrophage axes
Mitigating microplastic-induced organ Damage: Mechanistic insights from the microplastic-macrophage axes Open
We live in a world increasingly dominated by plastic, leading to the generation of microplastic particles that pose significant global health concerns. Microplastics can enter the body via ingestion, inhalation, and direct contact, accumul…
View article: The Antifungal Effects of Equol Against Candida albicans Involve Mitochondrial Dysfunction
The Antifungal Effects of Equol Against Candida albicans Involve Mitochondrial Dysfunction Open
Novel antifungal agents are urgently needed because of the increasing number of drug-resistant Candida strains encountered in clinical practice and the limited variety of available antifungal drugs. Equol, a metabolite of soy isoflavone gl…
View article: Benign and Malignant Breast Lesions: Differentiation Using Microstructural Metrics Derived from Time-Dependent Diffusion MRI
Benign and Malignant Breast Lesions: Differentiation Using Microstructural Metrics Derived from Time-Dependent Diffusion MRI Open
Time-dependent diffusion MRI–derived cell density demonstrated higher diagnostic performance compared with conventional apparent diffusion coefficient in differentiating malignant from benign breast lesions.
View article: Latent profile analysis of mental workload among emergency department nurses: a cross-sectional study
Latent profile analysis of mental workload among emergency department nurses: a cross-sectional study Open
View article: Predicting epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients through logistic regression: a model incorporating clinical characteristics, computed tomography (CT) imaging features, and tumor marker levels
Predicting epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients through logistic regression: a model incorporating clinical characteristics, computed tomography (CT) imaging features, and tumor marker levels Open
Background Approximately 60% of Asian populations with non-small cell lung cancer (NSCLC) harbor epidermal growth factor receptor (EGFR) gene mutations, marking it as a pivotal target for genotype-directed therapies. Currently, determining…
View article: Latent profile analysis of mental workload among emergency department nurses: a cross-sectional study
Latent profile analysis of mental workload among emergency department nurses: a cross-sectional study Open
Aim Emergency department nurses experience varying degrees of mental workload due to various reasons. The group with medium to high levels of mental workload needs to be given attention. There is limited research on the potential profiles …
View article: Transcriptome analysis reveals PRKCA as a potential therapeutic target for overcoming cisplatin resistance in lung cancer through ferroptosis
Transcriptome analysis reveals PRKCA as a potential therapeutic target for overcoming cisplatin resistance in lung cancer through ferroptosis Open
Cisplatin-based chemotherapy is the current standard care for lung cancer patients; however, drug resistance frequently develops during treatment, thereby limiting therapeutic efficacy.The molecular mechanisms underlying cisplatin resistan…
View article: Overexpression of 9-cis-Epoxycarotenoid Dioxygenase Gene, IbNCED1, Negatively Regulates Plant Height in Transgenic Sweet Potato
Overexpression of 9-cis-Epoxycarotenoid Dioxygenase Gene, IbNCED1, Negatively Regulates Plant Height in Transgenic Sweet Potato Open
Plant height is one of the key agronomic traits for improving the yield of sweet potato. Phytohormones, especially gibberellins (GAs), are crucial to regulate plant height. The enzyme 9-cis-epoxycarotenoid dioxygenase (NCED) is the key enz…
View article: Overexpression of 9-<em>cis</em>-Epoxycarotenoid Dioxygenase Gene, <em>IbNCED1</em>, Negatively Regulates Plant Height in Transgenic Sweet Potato
Overexpression of 9-<em>cis</em>-Epoxycarotenoid Dioxygenase Gene, <em>IbNCED1</em>, Negatively Regulates Plant Height in Transgenic Sweet Potato Open
Plant height is one of the key agronomic traits for improving the yield of sweetpotato. The phytohormones, especially gibberellins (GAs) are crucial to regulate plant height. The 9-cis-epoxycarotenoid dioxygenase (NCED) is the key enzyme f…
View article: Erratum: Secretions from Serratia marcescens Inhibit the Growth and Biofilm Formation of Candida spp. and Cryptococcus neoformans
Erratum: Secretions from Serratia marcescens Inhibit the Growth and Biofilm Formation of Candida spp. and Cryptococcus neoformans Open
View article: MiRNA-625-3p as novel biomarker promotes cell proliferation and metastasis of lung adenocarcinoma by targeting KLF9
MiRNA-625-3p as novel biomarker promotes cell proliferation and metastasis of lung adenocarcinoma by targeting KLF9 Open
Background. MicroRNAs (miRNAs) are emerging as potential blood-based biomarkers and involved carcinogenesis for various cancers, including lung adenocarcinoma (LUAD). Methods. In the present study, microarray was used to screen 2,549 miRNA…
View article: Toll-like Receptors and Thrombopoiesis
Toll-like Receptors and Thrombopoiesis Open
Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispens…
View article: Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes Thrombocytopoiesis
Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes Thrombocytopoiesis Open
Background: Thrombocytopenia has long been considered an important complication of chemotherapy and radiotherapy, which severely limits the effectiveness of cancer treatment and the overall survival of patients. However, clinical treatment…
View article: Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway
Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway Open
Ulcerative colitis (UC) is a complex immune-mediated inflammatory disease. In recent years, the incidence of UC has increased rapidly, however, its exact etiology and mechanism are still unclear. Based on the definite anti-inflammatory and…
View article: Comprehensive Control Strategy of Fuel Consumption and Emissions Incorporating the Catalyst Temperature for PHEVs Based on DRL
Comprehensive Control Strategy of Fuel Consumption and Emissions Incorporating the Catalyst Temperature for PHEVs Based on DRL Open
PHEVs (plug-in hybrid electric vehicles) equipped with diesel engines have multiple model transitions in the driving cycle for their particular structure. The high frequency of start–stop of a diesel engine will increase fuel consumption a…
View article: How prosocial behaviors are maintained in China: The relationship between communist authority and prosociality
How prosocial behaviors are maintained in China: The relationship between communist authority and prosociality Open
Objective Numerous studies have demonstrated that religious belief is associated with prosocial behavior. However, how do they maintain cooperation in societies with a predominating atheist population, such as China? Different primings (ex…
View article: Influence of Hold Time on Dwell Fatigue Behavior in IMI834 Disc Forging
Influence of Hold Time on Dwell Fatigue Behavior in IMI834 Disc Forging Open
View article: The m6A methyltransferase WTAP plays a key role in the development of diffuse large B-cell lymphoma via regulating the m6A modification of catenin beta 1
The m6A methyltransferase WTAP plays a key role in the development of diffuse large B-cell lymphoma via regulating the m6A modification of catenin beta 1 Open
In conclusion, these findings demonstrated that WTAP promotes DLBCL development via modulation of m6A methylation in CTNNB1.