Chunnan Liu
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View article: <scp>PDZK1</scp> Regulates the Stability and Function of <scp>ADRB2</scp> to Prevent Vascular Remodelling in Hypertension
<span>PDZK1</span> Regulates the Stability and Function of <span>ADRB2</span> to Prevent Vascular Remodelling in Hypertension Open
In this study, we found that PDZK1, a scaffold protein, interacts with the β₂‐adrenergic receptor (ADRB2) through its PDZ domains, stabilising ADRB2 by inhibiting its ubiquitination and proteasomal degradation. This study explored the PDZK…
View article: Splicing Shift of <i>RAC1</i> Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
Splicing Shift of <i>RAC1</i> Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer Open
Dysregulated RNA splicing has emerged as a pervasive yet understudied feature of cancer. The small GTPase RAC1 undergoes splicing changes in multiple cancers. However, the in vivo functional disparities between the two major RAC1 isoforms,…
View article: Expression and mechanism of endogenous relaxin in hypertensive patients
Expression and mechanism of endogenous relaxin in hypertensive patients Open
Objective This study aimed to investigate the role of endogenous relaxin in the development of hypertension by examining its expression in hypertensive patients and various hypertensive rat models. Methods In this study, 61 hypertensive pa…
View article: Radiation immunodynamics in patients with glioblastoma receiving chemoradiation
Radiation immunodynamics in patients with glioblastoma receiving chemoradiation Open
Introduction This is a prospective, rigorous inquiry into the systemic immune effects of standard adjuvant chemoradiotherapy, for WHO grade 4, glioblastoma. The purpose is to identify peripheral immunologic effects never yet reported in ke…
View article: Study on the Environmental Responsibility Measurement of Oil and Gas Resources Enterprises Based on Super Efficiency-DEA Model
Study on the Environmental Responsibility Measurement of Oil and Gas Resources Enterprises Based on Super Efficiency-DEA Model Open
With the rapid economic development, environmental pollution is getting worse.As heavily polluting enterprises, oil and gas resources enterprises, while playing an important role in national economy and the people's livelihood, must fulfil…
View article: Integrative tumour mutation burden with CD39 and PD-L1 for the prediction of response to PD-L1 blockade and adjuvant chemotherapy in muscle-invasive bladder cancer patients
Integrative tumour mutation burden with CD39 and PD-L1 for the prediction of response to PD-L1 blockade and adjuvant chemotherapy in muscle-invasive bladder cancer patients Open
Background CD39, a rate-limiting enzyme to convert extracellular ATP (eATP) to adenosine, has been reported to be a key modulator of immune response, but its correlation with therapeutic sensitivity remains obscure. We conducted this study…
View article: Activation of the Epstein-Barr virus DNA polymerase promoter by the BRLF1 immediate-early protein is mediated through USF and E2F.
Activation of the Epstein-Barr virus DNA polymerase promoter by the BRLF1 immediate-early protein is mediated through USF and E2F. Open
The Epstein-Barr virus (EBV) DNA polymerase (pol) is essential for the replication of viral genomes during productive EBV infection. We have previously reported that the EBV DNA pol promoter, which is TATA-less and constitutively inactive,…
View article: PEITC in End-Stage B-Cell Prolymphocytic Leukemia: Case Report of Possible Sensitization to Salvage R-CHOP
PEITC in End-Stage B-Cell Prolymphocytic Leukemia: Case Report of Possible Sensitization to Salvage R-CHOP Open
Given the limited data for R-CHOP in B-PLL, this patient's recovery suggests presensitization of B-PLL cells toward R-CHOP, potentially justifying further investigation.