Chunrong Yang
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View article: Zn2+ -mediated siRNA-doxorubicin Self-Assembled Nanoparticles amplify immunogenic cell death via aggravating redox dyshomeostasis for cancer therapy
Zn2+ -mediated siRNA-doxorubicin Self-Assembled Nanoparticles amplify immunogenic cell death via aggravating redox dyshomeostasis for cancer therapy Open
Immunogenic cell death (ICD), instigated by reactive oxygen species (ROS), has emerged as an efficacious strategy for augmenting the immunogenicity of tumor cells. However, the effects of ICD are severely diminished by elevated levels of g…
View article: Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy
Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy Open
Proteolysis targeting chimera (PROTAC), as an emerging approach for target protein degradation based on the intracellular ubiquitin‐protease system, is characterized by catalytic and reusability over traditional inhibitors. However, PROTAC…
View article: Transdermal microneedle integrating a biomimetic self-enhancing Fenton reaction nano-reactor for alleviating rheumatoid arthritis by inflammatory microenvironment remodeling
Transdermal microneedle integrating a biomimetic self-enhancing Fenton reaction nano-reactor for alleviating rheumatoid arthritis by inflammatory microenvironment remodeling Open
Rationale: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease, and persistent inflammation in multiple joints is an important sign for the progression of RA. To this end, we developed the transdermal microneedle …
View article: Proteolysis‐Targeting Chimera (PROTAC): A Revolutionary Tool for Chemical Biology Research
Proteolysis‐Targeting Chimera (PROTAC): A Revolutionary Tool for Chemical Biology Research Open
Proteolysis‐targeting chimera (PROTAC) technology is a revolutionary tool for drug discovery that simultaneously recruits E3 ligase and the protein of interest to induce ubiquitination and subsequent proteasomal degradation. Since the inau…
View article: Correction to: HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression
Correction to: HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression Open
View article: The oral antigen-adjuvant multivalent fusion vaccine P-VP56310-500-FlaC provides effective protective effect against grass carp reovirus infection
The oral antigen-adjuvant multivalent fusion vaccine P-VP56310-500-FlaC provides effective protective effect against grass carp reovirus infection Open
View article: HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression
HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression Open
View article: Giant ovarian solid and cystic masses mixed with three types of tumors: A rare case report and literature review
Giant ovarian solid and cystic masses mixed with three types of tumors: A rare case report and literature review Open
We present a case of a postmenopausal woman with a rare combination of thecoma-fibroma, serous cystadenoma and diffuse large B-cell lymphoma in the ovary. To the best of our knowledge, this is the first reported case of such a combination.…
View article: Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges
Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges Open
Ionic liquids (ILs) have been proven to be an effective technology for enhancing drug transdermal absorption. However, due to the unique structural components of ILs, the design of efficient ILs and elucidation of action mechanisms remain …
View article: Targeted H <sub>2</sub> S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane
Targeted H <sub>2</sub> S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane Open
Management of myocardial ischemia–reperfusion injury (MIRI) in reperfusion therapy remains a major obstacle in the field of cardiovascular disease, but current available therapies have not yet been achieved in mitigating myocardial injury …
View article: M1 Macrophage-Biomimetic Targeted Nanoparticles Containing Oxygen Self-Supplied Enzyme for Enhancing the Chemotherapy
M1 Macrophage-Biomimetic Targeted Nanoparticles Containing Oxygen Self-Supplied Enzyme for Enhancing the Chemotherapy Open
Tumor hypoxia is considered one of the key causes of the ineffectiveness of various strategies for cancer treatment, and the non-specific effects of chemotherapy drugs on tumor treatment often lead to systemic toxicity. Thus, we designed M…
View article: Design of Dual-Targeted pH-Sensitive Hybrid Polymer Micelles for Breast Cancer Treatment: Three Birds with One Stone
Design of Dual-Targeted pH-Sensitive Hybrid Polymer Micelles for Breast Cancer Treatment: Three Birds with One Stone Open
Breast cancer has a high prevalence in the world and creates a substantial socio-economic impact. Polymer micelles used as nano-sized polymer therapeutics have shown great advantages in treating breast cancer. Here, we aim to develop a dua…
View article: Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia
Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia Open
Background. Amentoflavone, a natural biflavone, exerts anti-inflammation, antioxidation, and antiapoptosis effects on many diseases. However, the mechanism of amentoflavone on neuroinflammation-related diseases has not been comprehensively…
View article: Mechanistic Study of Release Characteristics of Two Active Ingredients in Transdermal Patch Containing Lidocaine−Flurbiprofen Ionic Liquid
Mechanistic Study of Release Characteristics of Two Active Ingredients in Transdermal Patch Containing Lidocaine−Flurbiprofen Ionic Liquid Open
Ionic liquids (ILs) have been proven to be an efficient technology for enhancing drug skin permeability. However, the question of whether the two components of ILs are released synchronously in transdermal preparations has remained unclear…
View article: A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution Open
View article: Combining immune checkpoint blockade with ATP-based immunogenic cell death amplifier for cancer chemo-immunotherapy
Combining immune checkpoint blockade with ATP-based immunogenic cell death amplifier for cancer chemo-immunotherapy Open
View article: Self-Amplifying ROS Sensitive Prodrug Based Nanodecoys Circumventing Immune Resistance for Chemotherapy-Sensitized Immunotherapy
Self-Amplifying ROS Sensitive Prodrug Based Nanodecoys Circumventing Immune Resistance for Chemotherapy-Sensitized Immunotherapy Open
View article: A Conflict Risk Analysis of MAV\UAV Flight in Shared Airspace
A Conflict Risk Analysis of MAV\UAV Flight in Shared Airspace Open
The intelligent auxiliary decision-making (IADM) is emerging as a feasible solution for air traffic control (ATC) to reduce undesirable conflicts in shared airspace; meanwhile, unmanned aerial vehicles (UAVs) can be operated with enhanced …
View article: Characteristics of Gut Microbiota in Diarrhea-predominant Irritable Bowel Syndrome of Han Nationality in Southwest China
Characteristics of Gut Microbiota in Diarrhea-predominant Irritable Bowel Syndrome of Han Nationality in Southwest China Open
Backgroud To study of gut microbiota in IBS-D of Han nationality in Southwest China, explore its relationship with environmental factors and differential expression function of gut microbiota in patients. Methods 120 cases of IBS-D group a…
View article: Neutrophil Delivered Hollow Titania Covered Persistent Luminescent Nanosensitizer for Ultrosound Augmented Chemo/Immuno Glioblastoma Therapy
Neutrophil Delivered Hollow Titania Covered Persistent Luminescent Nanosensitizer for Ultrosound Augmented Chemo/Immuno Glioblastoma Therapy Open
Glioblastoma (GBM) is the most malignant brain tumor with unmet therapeutic demand. The blood‐brain‐barrier (BBB) and tumor heterogeneity limit the treatment effectiveness of various interventions. Here, an ultrasound augmented chemo/immun…
View article: Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma
Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma Open
The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted deliver…
View article: Binary Regulation of Tumor Microenvironment by pH-Responsive Reversible Shielding Nanoplatform for Improved Tumor Chemo-Immunotherapy
Binary Regulation of Tumor Microenvironment by pH-Responsive Reversible Shielding Nanoplatform for Improved Tumor Chemo-Immunotherapy Open
View article: Botulinum toxin as an ultrasensitive reporter for bacterial and SARS-CoV-2 nucleic acid diagnostics
Botulinum toxin as an ultrasensitive reporter for bacterial and SARS-CoV-2 nucleic acid diagnostics Open
View article: Integrin α1 promotes tumorigenicity and progressive capacity of colorectal cancer
Integrin α1 promotes tumorigenicity and progressive capacity of colorectal cancer Open
Colorectal cancer (CRC) is the second leading cause of death globally. Integrin α1 (ITGA1) belongs to integrin family and involves in regulating cell adhesion, invasion, proliferation and tumorigenicity, its expression is up-regulated in v…
View article: Secoisolariciresinol diglucoside suppresses Dextran sulfate sodium salt-induced colitis through inhibiting NLRP1 inflammasome
Secoisolariciresinol diglucoside suppresses Dextran sulfate sodium salt-induced colitis through inhibiting NLRP1 inflammasome Open
Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal inflammatory disease with high risks for colorectal cancer and extremely affect people's health. Secoisolariciresinol diglucoside (SDG), a major component of lignans, e…
View article: Frontispiece: Recent Progress in Fluorescence Signal Design for DNA‐Based Logic Circuits
Frontispiece: Recent Progress in Fluorescence Signal Design for DNA‐Based Logic Circuits Open
DNA computing has the potential to execute orders of magnitude more powerful functions than traditional silicon circuitry and has a wide range of applications in medical diagnosis, in situ analysis, and artificial intelligence. However, si…
View article: Improved Pharmacokinetics of Icariin (ICA) within Formulation of PEG-PLLA/PDLA-PNIPAM Polymeric Micelles
Improved Pharmacokinetics of Icariin (ICA) within Formulation of PEG-PLLA/PDLA-PNIPAM Polymeric Micelles Open
Icariin (ICA) is a major flavonoid that contains the active compound Epimedii Folium. However, ICA’s pharmacokinetic characteristics remain unsatisfactory due to its low bioavailability, and hence limited drugability. In order to improve i…
View article: Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate Open
The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of…
View article: Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate Open
The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of…
View article: Combined using of paclitaxel and salinomycin active targeting nanostructured lipid carriers against non-small cell lung cancer and cancer stem cells
Combined using of paclitaxel and salinomycin active targeting nanostructured lipid carriers against non-small cell lung cancer and cancer stem cells Open
The existing of avidity cancer stem cells (CSCs) made it an optical strategy to kill cancer cells and CSCs at the same time. Here, we constructed a CSCs specific nanocarrier naming T-S-NLC using the CD133+ targeting peptide TISWPPR (TR) as…