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PersADE: a database of personalized adverse drug events and their underlying molecular mechanisms Open

Zhuohang Yu, Yimeng Wang, Yintao Zhang, Xiaoxiao Hu, Lesang Shen , et al. · 2025

As a major burden on global healthcare systems, adverse drug events (ADEs) result in significant morbidity, mortality, and healthcare resource consumption. With the rapid advances in precision medicine, personalized ADEs and their molecula…

Dietary index for gut microbiota, genetic risk, and incidence of breast cancer: a prospective study Open

Xiyang Chen, Ying Wang, Li D, Bing Liu, Qian Fang , et al. · 2025

Cancer cells impede T cell early activation and drive immune evasion by transferring Tmem176b Open

Nengming Xiao, Xiaoyan Gao, Fang Liu, A‐Bin You, Ya Jin , et al. · 2025

Despite its remarkable clinical success in human cancer treatment, immune checkpoint blockade is effective only in a minority of patients. One major obstacle is tumor-driven impairment of T cell priming and early activation, however, the u…

Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies Open

Siwei Zheng, Wenwen Wang, Lesang Shen, Yao Yao, Wenjie Xia , et al. · 2024

The tumor microenvironment demonstrates great immunophenotypic heterogeneity, which has been leveraged in traditional immune-hot/cold tumor categorization based on the abundance of intra-tumoral immune cells. By incorporating the spatial i…

Immune mediated support of metastasis: Implication for bone invasion Open

Zengfeng Xin, Luying Qin, Yang Tang, Siyu Guo, Fangfang Li , et al. · 2024

Bone is a common organ affected by metastasis in various advanced cancers, including lung, breast, prostate, colorectal, and melanoma. Once a patient is diagnosed with bone metastasis, the patient's quality of life and overall survival are…

FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma Open

Dongmei Wang, Yuxiang Cao, Meiyao Meng, Jin Qiu, Chao Ni , et al. · 2024

Cholesterol metabolism is vital for multiple cancer progression, while how cholesterol affects lung, a low-cholesterol tissue, for cancer metastasis and the underlying mechanism remain unclear. In this study, we found that metastatic lung …

Supplementary Figure S7 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S7. CD24hiCD27+ Bregs induce drug resistance by activating NF-kB and STAT3 signalling in BC cells with effect stronger when in a direct contact.

Supplementary Figure S2 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S2. Comparison of CD24hiCD27+ Bregs from peripheral blood and LNs.

Supplementary Figure S9 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S9. CD24hiCD27+ Bregs are the main cellular sources of IL-10, IL-6 and TNF-α among CD45+ immune cells within the mLNs.

Supplementary Figure S1 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S1. The features of B cells in the mLNs of BC.

Supplementary Figure S4 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S4. CD24hiCD27+ Breg-induced drug resistance in BC is independent of small molecule substances.

Supplementary Table S4 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Table. S4. Characteristics of the patient samples and basic information.

Supplementary Figure S10 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S10. CD24hiCD27+ Bregs induce the upregulation of CD40L and PD-L1 in BC cells.

Supplementary Figure S1 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S1. The features of B cells in the mLNs of BC.

Supplementary Figure S12 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S12. The addition of anti-PD1/PD-L1 to neoadjuvant chemotherapy improves the pCR rate of patients with mLNs.

Supplementary Figure S8 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S8. Depletion of B cells within the LNs of mice by anti-CD20 antibody injection.

Supplementary Figure S11 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S11. Anti-PD-L1 treatment attenuates the activation of B cells and improves the treatment response rate of mLNs.

Supplementary Table S2 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Table. S2. Annotation of the 92 Olink biomarkers studied herein.

Supplementary Figure S5 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S5. Direct cell-cell contact between BC cells and CD24hiCD27+ Bregs endows BC cells with stronger stemness and drug resistance.

Supplementary Table S1 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Table. S1. List of antibodies used in this study.

Supplementary Figure S6 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S6. CD24hiCD27+ Bregs induce the drug resistance of BC cells by secreting IL-6 and TNF-α.

Supplementary Table S1 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Table. S1. List of antibodies used in this study.

Supplementary Figure S3 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S3. CD24hiCD27+ Bregs induce epithelial-mesenchymal transition and stemness of BC cells.

Supplementary Figure S6 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S6. CD24hiCD27+ Bregs induce the drug resistance of BC cells by secreting IL-6 and TNF-α.

Supplementary Figure S12 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S12. The addition of anti-PD1/PD-L1 to neoadjuvant chemotherapy improves the pCR rate of patients with mLNs.

Supplementary Figure S10 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S10. CD24hiCD27+ Bregs induce the upregulation of CD40L and PD-L1 in BC cells.

Supplementary Figure S9 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S9. CD24hiCD27+ Bregs are the main cellular sources of IL-10, IL-6 and TNF-α among CD45+ immune cells within the mLNs.

Supplementary Figure S3 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S3. CD24hiCD27+ Bregs induce epithelial-mesenchymal transition and stemness of BC cells.

Supplementary Table S4 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Table. S4. Characteristics of the patient samples and basic information.

Supplementary Figure S5 from CD24<sup>hi</sup>CD27<sup>+</sup> Bregs within Metastatic Lymph Nodes Promote Multidrug Resistance in Breast Cancer Open

Huanhuan Huang, Yao Yao, Lesang Shen, Jingxin Jiang, Ting Zhang , et al. · 2023

Fig. S5. Direct cell-cell contact between BC cells and CD24hiCD27+ Bregs endows BC cells with stronger stemness and drug resistance.

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