C. Xu
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View article: Meta-analysis of LVD versus PVE in treating liver cancer with an insufficient liver remnant
Meta-analysis of LVD versus PVE in treating liver cancer with an insufficient liver remnant Open
Background: This meta-analysis was conducted to evaluate the efficacy and safety of liver venous deprivation (LVD) compared with portal vein embolization (PVE) in promoting compensatory liver hypertrophy and improving surgical resectabilit…
View article: Epithelial‐Mesenchymal Transition States and Metabolic Reprogramming Related Signatures Predict Prognosis and Therapeutic Responses in <scp>HER2</scp> ‐Positive Breast Cancer
Epithelial‐Mesenchymal Transition States and Metabolic Reprogramming Related Signatures Predict Prognosis and Therapeutic Responses in <span>HER2</span> ‐Positive Breast Cancer Open
Background Epithelial‐mesenchymal transition (EMT) and metabolic reprogramming have been shown to regulate HER2 targeted therapy resistance and tumor metastasis. We aimed to establish an EMT‐associated and metabolic‐related prognostic mode…
View article: Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas
Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas Open
View article: Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2
Pyrotinib inhibits the tumorigenicity of HER2-positive non-small cell lung cancer by inducing ARIH1/ubiquitin/lysosome-dependent degradation of HER2 Open
View article: Immune-oncology-microbiome axis in lung cancer: from carcinogenesis to therapy—a narrative review
Immune-oncology-microbiome axis in lung cancer: from carcinogenesis to therapy—a narrative review Open
The IOM axis reveals dynamic interactions between immune cells, cancer cells, and microbes. Specific microbe-derived metabolites show promise as lung cancer biomarkers. Current microbiome-based therapy shows great potential in lung cancer …
View article: Nucleolar protein DCAF13 promotes non–small cell lung cancer cell proliferation via facilitating rDNA transcription and ribosome biogenesis
Nucleolar protein DCAF13 promotes non–small cell lung cancer cell proliferation via facilitating rDNA transcription and ribosome biogenesis Open
The nucleolus is an important nonmembranous organelle within the nucleus and is responsible for ribosome biogenesis. This process is frequently upregulated in tumors to support elevated protein synthesis and sustain tumor growth. The trans…
View article: Epidemiology and clinical characteristics of mesothelioma in the Chinese population: a multicenter study
Epidemiology and clinical characteristics of mesothelioma in the Chinese population: a multicenter study Open
Background: Mesothelioma is a rare and highly aggressive tumor that causes severe damage. However, there is a lack of systematic reports on the incidence and clinical characteristics of mesothelioma in the Chinese population. Objectives: T…
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis
Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis Open
Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare malignancy originating from mesothelial cells of the testicular tunica vaginalis. Due to its insidious onset and local aggressiveness, most patients are diagnosed at a…
View article: Inclusion of anti-vascular therapy as a promising option for later-line treatment of malignant pleural mesothelioma: a retrospective study
Inclusion of anti-vascular therapy as a promising option for later-line treatment of malignant pleural mesothelioma: a retrospective study Open
For patients with MPM requiring later-line treatment, the combination of chemotherapy and anti-vascular therapy may represent a viable therapeutic alternative, demonstrating an acceptable safety profile.
View article: Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4
Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4 Open
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC), characterized by limited treatment options and poor clinical outcomes. Aberrant FGFR signaling has been implicated in TNBC; however, the therapeutic …
View article: The Chain Mediating Role of Hope and Posttraumatic Growth Between Social Support and Psychological Distress Among Lung Cancer Patients
The Chain Mediating Role of Hope and Posttraumatic Growth Between Social Support and Psychological Distress Among Lung Cancer Patients Open
This study found that lung cancer patients exhibit high levels of psychological distress. Social support directly impacts psychological distress and acts through multiple pathways: the mediating effects of hope and PTG, as well as their se…
View article: P-586 Development and validation of an interpretable machine learning model for predicting pregnancy outcomes based on mitochondrial DNA (mtDNA) content and clinical features: a retrospective study
P-586 Development and validation of an interpretable machine learning model for predicting pregnancy outcomes based on mitochondrial DNA (mtDNA) content and clinical features: a retrospective study Open
Study question Can machine learning models be developed and validated based on mtDNA content and other relevant clinical characteristics to predict the probability of successful embryo implantation? Summary answer On the basis of large-sam…
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma
Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma Open
Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma…
View article: SplitFusion enables ultrasensitive gene fusion detection and reveals fusion variant-associated tumor heterogeneity
SplitFusion enables ultrasensitive gene fusion detection and reveals fusion variant-associated tumor heterogeneity Open
View article: The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis
The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis Open
REGISTRATION NUMBER: CRD42023430962.
View article: HOXC-AS1 and EZH2 interaction increase HOXC9 expression and promote the malignant transformation of oral leukoplakia
HOXC-AS1 and EZH2 interaction increase HOXC9 expression and promote the malignant transformation of oral leukoplakia Open
Objective: To investigate the role of HOXC9 in the transformation of oral leukoplakia (OLK) to oral squamous cell carcinoma (OSCC) and its effectiveness as a new molecular marker for oral leukoplakia carcinogenesis. Materials and…
View article: ECLUNG consensus/guidelines development principles and methods (2024 edition)
ECLUNG consensus/guidelines development principles and methods (2024 edition) Open
View article: Scaling Covalent Ligand Discovery via Library-Versus-Proteome Screening
Scaling Covalent Ligand Discovery via Library-Versus-Proteome Screening Open
View article: OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations
OKAIN: A comprehensive oncology knowledge base for the interpretation of clinically actionable alterations Open
The increased use of next-generation sequencing in clinical genetic testing has resulted in the identification of several genetic variations with possible therapeutic implications. We developed OKAIN (https://szcube.origimed.com), an algor…
View article: Identification of anoikis-related molecular patterns and the novel risk model to predict prognosis, tumor microenvironment infiltration and immunotherapy response in bladder cancer
Identification of anoikis-related molecular patterns and the novel risk model to predict prognosis, tumor microenvironment infiltration and immunotherapy response in bladder cancer Open
Background Anoikis, a unique form of cell death, serves as a vital part of the organism's defense by preventing shedding cells from re-attaching to the incorrect positions, and plays pivotal role in cancer metastasis. Nonetheless, the spec…
View article: Global profiling of arginine reactivity and ligandability in the human proteome
Global profiling of arginine reactivity and ligandability in the human proteome Open
Covalent small molecules targeting nucleophilic amino acids have emerged as a rapidly advancing frontier in covalent drug development, with a primary focus on cysteine and lysine residues. Despite the crucial biological roles of arginine, …
View article: Primary parenchymal squamous cell carcinoma of the kidney: A case report
Primary parenchymal squamous cell carcinoma of the kidney: A case report Open
BACKGROUND Primary squamous cell carcinoma (SCC) of the renal parenchyma is extremely rare, with only nine cases reported. CASE SUMMARY This study reports a 51-year-old man with primary SCC of the renal parenchyma. The patient was admitted…
View article: Case report: Polymorphous low-grade neuroepithelial tumor of the young and supratentorial ependymoma diagnosed in an adult male
Case report: Polymorphous low-grade neuroepithelial tumor of the young and supratentorial ependymoma diagnosed in an adult male Open
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a rare central nervous system (CNS) pathology predominantly observed in the pediatric population. Ependymomas also exhibit a peak incidence in early childhood, with rare …
View article: First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors
First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors Open
Oncogenic RET alteration is an important, tissue-agnostic therapeutic target across diverse cancers. We conducted a first-in-human phase 1 study on SY-5007, a potent and selective RET inhibitor, in patients with RET -altered solid tumors. …
View article: DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway
DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway Open
Cullin-RING ubiquitin ligase 4 (CRL4) is closely correlated with the incidence and progression of ovarian cancer. DDB1- and CUL4-associated factor 13 (DCAF13), a substrate-recognition protein in the CRL4 E3 ubiquitin ligase complex, is inv…
View article: DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway
DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway Open
Cullin-RING ubiquitin ligase 4 (CRL4) is closely correlated with the incidence and progression of ovarian cancer. DDB1- and CUL4-associated factor 13 (DCAF13), a substrate-recognition protein in the CRL4 E3 ubiquitin ligase complex, is inv…
View article: Performance study of air source heat pump system applying two types of distributors
Performance study of air source heat pump system applying two types of distributors Open
Air source heat pump heating is the most effective way to solve heating problems, and gas-liquid two-phase refrigerant in the uniform distribution and pressure drop problem of finned heat exchanger branch tube are the main factors affectin…
View article: A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma Open
Chronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed to study the association between inflamma…
View article: MAEL in human cancers and implications in prognostication and predicting benefit from immunotherapy over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma: a bioinformatic analysis
MAEL in human cancers and implications in prognostication and predicting benefit from immunotherapy over VEGFR/mTOR inhibitors in clear cell renal cell carcinoma: a bioinformatic analysis Open
Maelstrom (MAEL), a novel cancer/testis-associated gene, may facilitate the initiation and progression of human malignancies, warranting comprehensive investigations. Single-cell and tissue-bulk transcriptomic data demonstrat…
View article: Rechallenge of immune checkpoint inhibitors in advanced non‐small cell lung cancer
Rechallenge of immune checkpoint inhibitors in advanced non‐small cell lung cancer Open
Immune checkpoint inhibitor (ICI) rechallenge in non‐small cell lung cancer (NSCLC) is a promising therapeutic strategy. The situation for ICI rechallenge can be divided into three categories: adverse events (AEs); resistance to ICIs, and …