Explanipedia

Polymerase theta inhibition impairs tumor growth and amplifies melphalan-induced DNA damage in multiple myeloma Open

Qun Li, Chi Ma, Liping Zuo, Aoshuang Xu, Bo Zhang , et al. · 2025

Collectively, our results confirm Polθ as a promising prognostic biomarker and highlight its potential to serve as a synthetic lethal target that can be used in combination with melphalan for the treatment of MM.

Efficacy and toxicity of treatment of smoldering multiple myeloma: a systematic review and meta-analysis Open

Lixin Quan, Qun Li, Chi Ma, Xinxin Cao, Chunyan Sun · 2025

Early intervention may delay progression and improve clinical responses, especially in high-risk SMM. However, adverse events (AEs) warrant caution. More well-designed RCTs are needed to confirm our findings.

[Development, reliability, and validity of a treatment-related quality of life scale for Chinese patients with multiple myeloma]. Open

Chunyan Sun, Zhen Cai, B Chen, L J Chen, Weiyan Chen , et al. · 2025

Objective: To develop a treatment-related quality of life scale for Chinese patients with multiple myeloma (MM) and to test its reliability and validity. Methods: The initial scale was constructed through a literature search,…

Development and validation of a prognostic staging system for primary plasma cell leukemia Open

Mengru Tian, Gang An, Weijun Fu, Wenqiang Yan, Li Lu , et al. · 2025

A comprehensive analysis of bone marrow-derived cytogenetic abnormalities in multiple myeloma patients with extramedullary disease Open

Juan Xu, Huijuan Yang, Jingcao Huang, Ting Niu, Chunyan Sun , et al. · 2025

LDHAL6B is a novel prognostic marker and promotes disease progression in multiple myeloma Open

Liping Zuo, Zhixin Li, Li Cai, Qun Li, Fengjuan Fan , et al. · 2025

Not available.

A Comprehensive Analysis of Bone Marrow-Derived Cytogenetic Abnormalities in Multiple Myeloma Patients with Extramedullary Disease Open

Juan Xu, Huijuan Yang, Jingcao Huang, Ting Niu, Chunyan Sun , et al. · 2025

Extramedullary disease (EMD) in multiple myeloma (MM) remains a critical clinical challenge due to its aggressive behavior and resistance to conventional therapies. While cytogenetic abnormalities are recognized contributors to MM progress…

Methionine Dependency and Restriction in Cancer: Exploring the Pathogenic Function and Therapeutic Potential Open

Chi Ma, Aoshuang Xu, Liping Zuo, Qun Li, Fengjuan Fan , et al. · 2025

Methionine, an essential amino acid, is obtained by dietary intake to fulfill the requirements of our bodies. Accumulating evidence indicates that methionine plays a pivotal role in various biological processes, including protein synthesis…

Therapeutic Target Discovery for Multiple Myeloma: Identifying Druggable Genes via Mendelian Randomization Open

Shijun Jiang, Fengjuan Fan, Qun Li, Liping Zuo, Aoshuang Xu , et al. · 2025

Background: Multiple myeloma (MM) is a hematological malignancy originating from the plasma cells present in the bone marrow. Despite significant therapeutic advancements, relapse and drug resistance remain major clinical challenges, highl…

Clonal Hematopoietic Mutations in Plasma Cell Disorders: Clinical Subgroups and Shared Pathogenesis Open

Xuezhu Wang, Liping Zuo, Y C Yu, Xinyi Xiong, Jian Xu , et al. · 2025

Plasma cell disorders (PCDs) are marked by the clonal proliferation of abnormal plasma cells and bone marrow plasma cells (BMPCs), causing various clinical complications. These PCDs include subtypes with distinct clinical features. Multipl…

Comprehensive analysis of anoikis-related gene signature in ulcerative colitis using machine learning algorithms Open

Peng Liu, Chunyan Sun, Xiaojuan Wang, Bing Han, Fuchun Sun , et al. · 2025

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with an idiopathic origin, characterized by persistent mucosal inflammation. Anoikis is a programmed cell death mechanism activated during carcinogenesis to eliminate undetect…

COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression Open

Yajun Wang, Bo Zhang, Fengjuan Fan, Fei Zhao, Jian Xu , et al. · 2025

Background: Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells, with extramedullary myeloma (EMM) being an aggressive form involving malignant infiltration beyond the bone marrow. Co…

Development of an Artificial Intelligence-Based Early Diagnostic System for Light-Chain Amyloidosis Open

Wei Yan, Tao He, Haoze Xu, Jian‐Min Chen, Xiaoyu Liu , et al. · 2025

Programmed cell death 1 inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic urothelial carcinoma: a single-center experience Open

Xing Huang, Chunyan Sun, Peng Zhang, Lei Wang · 2024

Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease Open

Yutong Wang, Qiming Xu, Yuan Li, Yongbin Su, Ling Wang , et al. · 2024

Asymptomatic multicentric Castleman disease: a potential early stage of idiopathic MCD Open

Lu Zhang, Qinhua Liu, Hui Zhou, Huilai Zhang, Yujun Dong , et al. · 2024

According to the diagnostic criteria for human herpesvirus 8 (HHV-8)–negative/idiopathic multicentric Castleman disease (iMCD) proposed by Castleman Disease Collaborative Network in 2017, there is a group of HHV-8–negative patients with mu…

Class II ferroptosis inducers are a novel therapeutic approach for t(4;14)-positive multiple myeloma Open

Jiasi Zhang, Yuxi Liu, Liping Zuo, Fengjuan Fan, Han Yan , et al. · 2024

Multiple myeloma (MM) is a clonal plasma cell malignancy that is characterized by genetic heterogeneity. The cytogenetic abnormality t(4;14) strongly predicts poor outcome in patients with MM, even in the era of novel drugs. Ferroptosis is…

Bispecific Antibodies for Multiple Myeloma: Recent Advancements and Strategies for Increasing Their Efficacy Open

Moran Wang, Chaofan Wang, Jun Deng, Huafang Wang, Chunyan Sun , et al. · 2024

The treatment options for multiple myeloma (MM) have undergone significant transformation with the advent of immunotherapy. Novel therapies that focus on tumor antigens now drive advances in MM research. Bispecific antibodies (bsAbs) lever…

Advances in nano-immunotherapy for hematological malignancies Open

Jian Xu, Wenqi Liu, Fengjuan Fan, Bo Zhang, Chunyan Sun , et al. · 2024

Early progression is associated with worse survival in patients with Waldenström’s macroglobulinemia Open

Wenjie Xiong, Zanzan Wang, Huihan Wang, Chunrui Li, Xiaoxia Chu , et al. · 2024

Early progression of disease within 24 months (POD24) of diagnosis is associated with inferior overall survival (OS) in follicular lymphoma, but its prognostic role in Waldenström’s macroglobulinemia (WM) is still unclear. Here, we perform…

Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis Open

Qun Li, Lisha Ai, Liping Zuo, Junying Li, Fei Zhao , et al. · 2024

Our meta-analysis confirmed that the increased number of CPCs had a negative impact on the PFS and OS of MM patients. Therefore, CPCs could be a promising prognostic biomarker that helps with risk stratification and disease monitoring.

MH-STRALP: A scoring system for prognostication in patients with upper gastrointestinal bleeding Open

Jun-Nan Hu, Fei Xu, Ya-Rong Hao, Chunyan Sun, Kaiming Wu , et al. · 2024

BACKGROUND Upper gastrointestinal bleeding (UGIB) is a common medical emergency and early assessment of its outcomes is vital for treatment decisions. AIM To develop a new scoring system to predict its prognosis. METHODS In this retrospect…

Different evasion strategies in multiple myeloma Open

Chaofan Wang, Wanting Wang, Moran Wang, Jun Deng, Chunyan Sun , et al. · 2024

Multiple myeloma is the second most common malignant hematologic malignancy which evolved different strategies for immune escape from the host immune surveillance and drug resistance, including uncontrolled proliferation of malignant plasm…

[Diagnosis and treatment understanding of Waldenström macroglobulinemia in China: a cross-sectional study]. Open

Shuhua Yi, Wujun Xiong, Xinxin Cao, Chunyan Sun, Juan Du , et al. · 2024

Objective: To conduct a nationwide physician survey to better understand clinicians' disease awareness, treatment patterns, and experience of Waldenström macroglobulinemia (WM) in China. Methods: This cross-sectional study wa…

Development of a nomogram prognostic model for early Grade ≥ 3 infection in newly diagnosed multiple myeloma based on immunoparesis Open

Min Zhang, Qianwen Cheng, Fei Zhao, Aoshuang Xu, Qun Li , et al. · 2023

In this study, we established a nomogram model to predict early grade ≥ 3 infection in NDMM patients. This model can assist clinicians in identifying NDMM patients with high-risk infections and improve their prognosis through early interve…

Hematologists’ awareness of venous thromboembolism in multiple myeloma: a national survey in China Open

Qun Li, Bo Zhang, Qianwen Cheng, Fei Zhao, Junying Li , et al. · 2023

The results of our study showed that a large proportion of Chinese hematologists failed to recognize the VTE risk factors, most of them cannot select appropriate thromboprophylaxis for different MM therapeutic regimens and lack awareness o…

Pomalidomide, bortezomib, and dexamethasone for newly diagnosed multiple myeloma patients with renal impairment Open

Yuan Jian, Long Chang, Mingxia Shi, Ying Sun, Xiaoxia Chu , et al. · 2023

Identification of ferroptosis-related diagnostic markers in primary Sjögren's syndrome based on machine learning Open

Hsiu‐Chiung Yang, Chunyan Sun, Xuewen Wang, Tianfang Wang, Conghua Xie , et al. · 2023

This study offers valuable insights into the pathogenesis of pSS and highlights the importance of targeting ferroptosis-related DEGs, which suggests a novel treatment strategy for pSS.

Oligosecretory Waldenström macroglobulinemia exhibits excellent treatment response and outcomes Open

Wenjie Xiong, Ying Yu, Chunyan Sun, Juan Du, Zhen Cai , et al. · 2023

Not available.

P974: INTERIM ANALYSIS OF THE LAUNCH STUDY-A MULTICENTER, OPEN-LABEL STUDY OF SELINEXOR, DEXAMETHASONE PLUS CHEMOTHERAPY DRUGS IN RELAPSED/ REFRACTORY MULTIPLE MYELOMA Open

Chunyan Sun, Baijun Fang, Guangxun Gao, Aili He, Fei Zhao , et al. · 2023

Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Exportin 1 (XPO1) participates the nuclear export of tumor suppressor proteins (TSPs), is associated with poor prognosis and drug resistance (PI or IMiD) in MM. Se…

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