Chunyan Tian
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View article: Genome-Wide Identification, Evolution, and Expression Patterns of the Fructose-1,6-Bisphosphatase Gene Family in Saccharum Species
Genome-Wide Identification, Evolution, and Expression Patterns of the Fructose-1,6-Bisphosphatase Gene Family in Saccharum Species Open
Fructose-1,6-bisphosphatase (FBP) is a crucial regulatory enzyme in sucrose synthesis and photosynthetic carbon assimilation, functioning through two distinct isoforms: cytosolic FBP (cyFBP) and chloroplastic FBP (cpFBP). However, the iden…
View article: Effect of pelvic floor muscle combined with pulmonary rehabilitation training on lung function in elderly patients after surgery for intertrochanteric fractures of the femur: a randomized controlled trial
Effect of pelvic floor muscle combined with pulmonary rehabilitation training on lung function in elderly patients after surgery for intertrochanteric fractures of the femur: a randomized controlled trial Open
View article: Deep Profiling of Oocyte Aging Enabled by Simple One-Step Vial-Based Pretreatment and Single-Cell Proteomics
Deep Profiling of Oocyte Aging Enabled by Simple One-Step Vial-Based Pretreatment and Single-Cell Proteomics Open
Single-cell proteomics is a pivotal technology for studying cellular phenotypes, offering unparalleled insights into cellular heterogeneity and dynamic functions. Technical improvement in mass spectrometry instruments and sample preparatio…
View article: [Retracted] ABCG1 as a potential oncogene in lung cancer
[Retracted] ABCG1 as a potential oncogene in lung cancer Open
[This retracts the article DOI: 10.3892/etm.2017.4393.].
View article: Examination of factors causing postoperative pneumonia in elderly hip fracture patients: A narrative review
Examination of factors causing postoperative pneumonia in elderly hip fracture patients: A narrative review Open
With the increasing aging problem, the number of fractures in the elderly is also increasing, of which hip fractures are more common, known as “the last fracture of life.” Postoperative pneumonia (POP) is a common complication of hip fract…
View article: Recent Advances in Sugarcane Leaf Scald Disease: Pathogenic Insights and Sustainable Management Approaches
Recent Advances in Sugarcane Leaf Scald Disease: Pathogenic Insights and Sustainable Management Approaches Open
Sugarcane, a key cash crop in tropical and subtropical regions, is primarily cultivated for sucrose and bioethanol. However, Sugarcane Leaf Scald Disease, caused by the Gram-negative bacterium Xanthomonas albilineans, significantly threate…
View article: MINDY1 Induces PD-L1 Deubiquitination to Promote Immune Escape in Hepatocellular Carcinoma by the Wnt/β-Catenin Pathway
MINDY1 Induces PD-L1 Deubiquitination to Promote Immune Escape in Hepatocellular Carcinoma by the Wnt/β-Catenin Pathway Open
MINDY1 promotes PD-L1 deubiquitination and inhibits CD8+ T cell activation by stimulating the Wnt/β-catenin pathway, consequently promoting HCC tumor immune escape.
View article: Unraveling the Impact of Geographic Distance on the Microbial Communities of Jiuyao Samples in the Yangtze River Basin: From Upstream to Downstream
Unraveling the Impact of Geographic Distance on the Microbial Communities of Jiuyao Samples in the Yangtze River Basin: From Upstream to Downstream Open
View article: Three Sugarcane Flowering Locus T-Like Genes Function Antagonistically to Regulate Floral Initiation Under Induced Photoperiodic Conditions
Three Sugarcane Flowering Locus T-Like Genes Function Antagonistically to Regulate Floral Initiation Under Induced Photoperiodic Conditions Open
View article: Simple One-step Vial-based Pretreatment for Deep Single-cell Proteomics and Its Application to Oocyte Aging
Simple One-step Vial-based Pretreatment for Deep Single-cell Proteomics and Its Application to Oocyte Aging Open
Single-cell proteomics is a pivotal technology for studying cellular phenotypes, offering unparalleled insights into cellular heterogeneity and dynamic functions. Technical improvement in mass spectrometry instrument and sample preparation…
View article: ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by Recruiting SMYD3 in Breast Cancer
ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by Recruiting SMYD3 in Breast Cancer Open
Most deaths in breast cancer patients are attributed to metastasis, and lung metastasis is associated with a particularly poor prognosis; therefore it is imperative to identify potential target for intervention. The transforming growth fac…
View article: Git2 deficiency promotes MDSCs recruitment in intestine via NF-κB-CXCL1/CXCL12 pathway and ameliorates necrotizing enterocolitis
Git2 deficiency promotes MDSCs recruitment in intestine via NF-κB-CXCL1/CXCL12 pathway and ameliorates necrotizing enterocolitis Open
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease in preterm infants and the most common cause of neonatal death, whereas the molecular mechanism of intestinal injury remains unclear accompanied by deficiency of effectiv…
View article: Application of Career Management and Competency Model in the Construction of New Employee Training System in Enterprises
Application of Career Management and Competency Model in the Construction of New Employee Training System in Enterprises Open
New employees are at the beginning of the career path and the bottom of the business layer. They not only need to master basic job skills, but also need to know the corporate culture, corporate value, system regulations, development strate…
View article: Genetic Engineering for Enhancing Sugarcane Tolerance to Biotic and Abiotic Stresses
Genetic Engineering for Enhancing Sugarcane Tolerance to Biotic and Abiotic Stresses Open
Sugarcane, a vital cash crop, contributes significantly to the world’s sugar supply and raw materials for biofuel production, playing a significant role in the global sugar industry. However, sustainable productivity is severely hampered b…
View article: Proteomics Identifies LUC7L3 as a Prognostic Biomarker for Hepatocellular Carcinoma
Proteomics Identifies LUC7L3 as a Prognostic Biomarker for Hepatocellular Carcinoma Open
Alternative splicing has been shown to participate in tumor progression, including hepatocellular carcinoma. The poor prognosis of patients with HCC calls for molecular classification and biomarker identification to facilitate precision me…
View article: Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin
Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin Open
View article: Association analysis of three breeding traits with SSR markers and exploration of elite alleles in sugarcane
Association analysis of three breeding traits with SSR markers and exploration of elite alleles in sugarcane Open
View article: From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation
From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation Open
PROTAC is a rapidly developing engineering technology for targeted protein degradation using the ubiquitin–proteasome system, which has promising applications for inflammatory diseases, neurodegenerative diseases, and malignant tumors. Thi…
View article: Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma
Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma Open
Stable infiltration of myeloid cells, especially tumor-associated M2 macrophages, acts as one of the essential features of the tumor immune microenvironment by promoting the malignant progression of hepatocellular carcinoma (HCC). However,…
View article: Integrated analysis of tumor and adjacent non-tumor proteomic data reveals SERPINH1 as a recurrence biomarker and drug target in hepatocellular carcinoma
Integrated analysis of tumor and adjacent non-tumor proteomic data reveals SERPINH1 as a recurrence biomarker and drug target in hepatocellular carcinoma Open
The high rate of postoperative recurrence contributes to the poor outcome in hepatocellular carcinoma (HCC), and effective strategies for managing recurrence are currently lacking. Based on seven pairs of tumors and non-tumor adjacent tiss…
View article: RNF149 Promotes HCC Progression through Its E3 Ubiquitin Ligase Activity
RNF149 Promotes HCC Progression through Its E3 Ubiquitin Ligase Activity Open
Hepatocellular carcinoma (HCC) accounts for over 80% of cases among liver cancer, with high incidence and poor prognosis. Thus, it is of valuable clinical significance for discovery of potential biomarkers and drug targets for HCC. In this…
View article: Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma
Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma Open
Background The molecular subtypes of hepatocellular carcinoma (HCC) with the worst prognosis are characterized by immune disorders dominated by myeloid cell infiltration, but how to accurately screen these patients for accurate diagnosis a…
View article: Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation
Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation Open
Background High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in eliciting intestinal…
View article: [Retracted] MicroRNA‑381 serves as a prognostic factor and inhibits migration and invasion in non‑small cell lung cancer by targeting LRH‑1
[Retracted] MicroRNA‑381 serves as a prognostic factor and inhibits migration and invasion in non‑small cell lung cancer by targeting LRH‑1 Open
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the western blotting data shown in Fig. 5C, and the cell migration and invasion data shown in Figs. 3C and D and 6B and C…
View article: SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer
SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer Open
Endoplasmic reticulum (ER) homeostasis has been implicated in the pathogenesis of various forms of cancer; however, our understanding of the role of ER quality control mechanisms in tumorigenesis remains incomplete. Here, we show that the …
View article: The signaling pathways regulated by KRAB zinc-finger proteins in cancer
The signaling pathways regulated by KRAB zinc-finger proteins in cancer Open
Kruppel-associated box (KRAB) zinc-finger proteins (KRAB-ZFPs) are the largest transcriptional/transcription-regulatory factor family in mammalian cells. The amino-terminal KRAB domain, which recruits other transcription-regulating protein…
View article: ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation
ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation Open
Background Dysfunctional p53 signaling is one of the major causes of hepatocellular carcinoma (HCC) tumorigenesis and development, but the mechanisms underlying p53 inactivation in HCC have not been fully clarified. The role of Krüppel-ass…
View article: Additional file 4 of ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation
Additional file 4 of ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation Open
Additional file 4: Table S3. ZNF498 mRNA level and TP53 mutational status in HCC patients from TCGA datasets.
View article: Additional file 1 of ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation
Additional file 1 of ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation Open
Additional file 1: Supplementary Figure S1. Anti-ZNF498 antibody specifically recognizes ZNF498. Supplementary Figure S2. ZNF498 promotes the initiation of DEN-induced HCC. Supplementary Figure S3. ZNF498 interacts with p53, represses p53 …
View article: Sel1L-Hrd1 ER-Associated Degradation Suppresses Hepatocyte Hyperproliferation and Liver Cancer
Sel1L-Hrd1 ER-Associated Degradation Suppresses Hepatocyte Hyperproliferation and Liver Cancer Open