Explanipedia

PANoptosis in hepatocellular carcinoma: Underlying mechanisms Open

Chunyi Wen, Hai-lian Lyu · 2025

PANoptosis is an inflammatory programmed cell death pathway possessing critical characteristics of apoptosis, pyroptosis, and necroptosis. It is regulated by PANoptosome complexes, involves interaction between these three key programmed ce…

Tailoring Human Joint-on-a-Chip: from Biological Principles, Materials, to Disease Modeling Open

Xuejiao Wang, Louis Jun Ye Ong, Chunyi Wen · 2025

Lacticaseibacillus rhamnosus AC1 Aggravates Bone Loss in a Male Rat Model of Deoxycorticosterone Acetate (DOCA)-Salt-Induced Osteoporosis Open

Xiaoqing Kuang, Haicui Wu, Tim‐Fat Shum, Chunyi Wen, Jiachi Chiou · 2025

Background/Objectives: Osteoporosis is a prevalent and debilitating skeletal disease characterized by a progressive loss of bone mass and deterioration of bone microarchitecture. Probiotics have emerged as a potential therapeutic tool for …

Development and validation of a generalisable survival model to predict osteoarthritis progression Open

H H T Li, Lok-Chun Chan, PK Chan, Chunyi Wen · 2025

Artificial intelligence in osteoarthritis research: summary of the 2025 OARSI pre-congress workshop Open

Matthew S. Harkey, K.E. Costello, Bella Mehta, Chunyi Wen, Anne‐Marie Malfait , et al. · 2025

Cross-disciplinary collaboration and AI literacy are essential to responsibly advance AI integration in OA research. The workshop's collective insights call for ethical, patient-centered approaches that leverage AI's strengths while preser…

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis Open

Said el Bouhaddani, Lin Zhu, Nienke Nijhof, S.C. Mastbergen, Chunyi Wen , et al. · 2025

Osteoarthritis (OA) is a multifactorial, mechano-inflammatory joint disorder characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling. Despite its high prevalence and significant impact on quality of l…

Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression Open

Lin Zhu, Xin Diao, Chenrui Yuan, Lawrence Chun‐Man Lau, Jianing Wang , et al. · 2025

Rationale: Synovial fibrosis, driven by myofibroblast activation and extracellular matrix remodelling, is fundamental in osteoarthritis (OA) pathogenesis but remains poorly understood due to the spatial heterogeneity of synovial inf…

Ambroxol hydrochloride as an antibiofilm agent synergizes with tetracycline antibiotics against mature biofilms of multidrug-resistant Klebsiella pneumoniae Open

T. Zhang, Xinxin Gao, Mengting Liu, Chunyi Wen, Peng Jin , et al. · 2025

Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is a major pathogen responsible for hospital-acquired infections, associated with high morbidity and mortality. Biofilm formation plays a key role in the pathogenicity of MDR-KP and…

Diffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes Open

S. H. Lau, Lok-Chun Chan, Tianshu Jiang, Jiang Zhang, Xiangqiao Meng , et al. · 2025

Corrigendum to ‘Networking in the osteoarthritis research community in the digital era’ [Osteoarthr Cartil Open 7 (2025) 100650] Open

Rachel K Nelligan, Anca Maglaviceanu, Jocelyn L. Bowden, Jackie L. Whittaker, Tobias Winkler , et al. · 2025

Shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells and augment bone regeneration Open

Huaqian Liu, Weiwei Zhao, Yuhe Yang, Ho‐Pan Bei, Qunchao Chen , et al. · 2025

Networking in the osteoarthritis research community in the digital era Open

Rachel K Nelligan, Anca Maglaviceanu, Jocelyn L. Bowden, Jackie L. Whittaker, Tobias Winkler , et al. · 2025

Smartphone-Derived Joint Angular Velocities in Sit-to-Stand Motion: A Novel Spatiotemporal Marker for Symptomatic Knee Osteoarthritis Open

Chunyi Wen · 2025

Background and Objective: Knee osteoarthritis (OA) is a debilitating condition that compromises mobility and exacerbates knee pain, necessitating accurate and accessible diagnostic tools. Traditional motion capture technology, while effect…

Predicting periprosthetic joint infection in primary total knee arthroplasty: a machine learning model integrating preoperative and perioperative risk factors Open

Yuk Yee Chong, Lawrence Chun‐Man Lau, Tianshu Jiang, Chunyi Wen, Jiang Zhang , et al. · 2025

Our study presented the first machine learning model in Asia to predict periprosthetic joint infection following primary total knee arthroplasty. We enhanced the model's usability by providing global and local interpretations. This tool pr…

Tissue Mimetic Membranes for Healing Augmentation of Tendon–Bone Interface in Rotator Cuff Repair Open

Yuwei Zhu, Bingyang Dai, Shian Zhang, Jun Liu, Shunxiang Xu , et al. · 2025

The globally prevalent rotator cuff tear has a high re‐rupture rate, attributing to the failure to reproduce the interfacial fibrocartilaginous enthesis. Herein, a hierarchically organized membrane is developed that mimics the heterogeneou…

Multiscalar circulation system: A key issue in artificial organ manufacturing Open

Chongjian Gao, Zhongqing Wu, Chunyi Wen, Haobo Pan, Changshun Ruan · 2025

In situ bioprinting: Tailored printing strategies for regenerative medicine Open

Chengwei Hu, Chenmin Wang, Shaoquan Bian, Weichen Qi, Bo Liu , et al. · 2024

In recent years, three-dimensional (3D) bioprinting has emerged as a revolutionary biological manufacturing technology. Despite significant progress, current bioprinting technologies face critical barriers, such as the need for in vi…

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids Open

Chiu Wang Chau, Alex To, Rex Au-Yeung, Kaiming Tang, Yang Xiang , et al. · 2024

SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task. Organoids from human tissues ad…

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids Open

Chiu Wang Chau, Alex To, Rex Au-Yeung, Kaiming Tang, Yang Xiang , et al. · 2024

SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task. Organoids from human tissues ad…

Subchondral bone expansion in advanced knee osteoarthritis: Relation with radiographic severity and role in surgical decision-making Open

Wei Wang, Tianshu Jiang, Jiang Zhang, Jun Liu, Lok-Chun Chan , et al. · 2024

Engineering an extracellular matrix-functionalized, load-bearing tendon substitute for effective repair of large-to-massive tendon defects Open

Shuting Huang, Ying Rao, Meng Zhou, Anna Blocki, Xiao Chen , et al. · 2024

Radiomics signature of osteoarthritis: Current status and perspective Open

Tianshu Jiang, S. H. Lau, Jiang Zhang, Lok-Chun Chan, Wei Wang , et al. · 2024

Radiomics is a novel approach used in oncology, and it may also play an essential role in the diagnosis and prognosis of OA. By transforming medical images from qualitative interpretation to quantitative data, radiomics could be the soluti…

Radiomics analysis of patellofemoral joint improves knee replacement risk prediction: Data from the Multicenter Osteoarthritis Study (MOST) Open

Jiang Zhang, Tianshu Jiang, Lok-Chun Chan, S. H. Lau, Wei Wang , et al. · 2024

Feasible non-surgical options for management of knee osteoarthritis during the COVID-19 pandemic and beyond Open

J Khoo, PK Chan, Chunyi Wen, Lawrence Chun‐Man Lau, Thomas KC Leung , et al. · 2024

An interpretable knee replacement risk assessment system for osteoarthritis patients Open

H H T Li, Lok-Chun Chan, PK Chan, Chunyi Wen · 2024

A self-administrable and interpretable KR survival model was developed, underscoring a KR risk scoring system to stratify KOA patients. It will encourage regular self-assessments within the community and facilitate personalised healthcare …

A Small‐Molecule Polycationic Crosslinker Boosts Alginate‐Based Bioinks for Extrusion Bioprinting (Adv. Funct. Mater. 9/2024) Open

Chongjian Gao, Lan Tang, Huawei Qu, Mingming Wu, Tian Zhou , et al. · 2024

Alginate-Based Bioinks In article number 2310369, Pinpin Wang, Nan Xu, Changshun Ruan, and co-workers describe a small-molecule polycationic crosslinker (i.e., ɛ-polylysine) enhanced alginate-based hydrogel, which reshines the vitality of …

Organoids in concert: engineering in vitro models toward enhanced fidelity Open

Zhengkun Chen, Ryohichi Sugimura, Yu Shrike Zhang, Changshun Ruan, Chunyi Wen · 2024

Organoids have emerged as a powerful platform for studying complex biological processes and diseases in vitro. However, most studies have focused on individual organoids, overlooking the inter‐organ interactions in vivo and limiting the ph…

Slot-In Snap-Back, Homeothermal,Shape Memory Bone Screws Loading L-Arginine and Ca2+ Propagate Mechanical Stimulation, Energize Bone Cells and Augment Bone Regeneration Open

Huaqian Liu, Weiwei Zhao, Yuhe Yang, Ho-Pan Bei, Qunchao Chen , et al. · 2024

Organoids: Principle, application and perspective Open

Kaizheng Liu, Xinyi Fang, Abdellah Aazmi, Qingzhe Wang, Xiao‐Feng Gong , et al. · 2024

Organoid technology, a notable advancement in biomedical engineering, has emerged over the past decade, offering significant scientific and therapeutic potential. By accurately mimicking the structural and functional intricacies of human o…

ChatGPT for scientific writing — The coexistence of opportunities and challenges Open

Liangbin Zhou, Alex Chao Wu, Péter Hegyi, Chunyi Wen, Ling Qin · 2024

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