Chunyu Jiang
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View article: Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics
Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics Open
The SPHK-S1P signaling axis is a core pathway driving sphingolipid metabolic dysregulation in the prefrontal cortex in ADHD. Targeted inhibition of this pathway synergistically modulates the expression levels of proteins associated with do…
View article: Heterogeneous Interactions During Bubble–Oil Droplet Contact in Water
Heterogeneous Interactions During Bubble–Oil Droplet Contact in Water Open
Oily wastewater is extensively generated during the petroleum extraction and refining processes, as crude oil production water and from the effluent systems in petrochemical enterprises. The discharge standards for such wastewater are stri…
View article: Oxidative Stress, Energy Metabolism Disorder, Mitochondrial Damage, and miR-144 Participated in Molecular Mechanisms of 4-Octylphenol-Caused Cardiac Autophagic Damage in Common Carps (Cyprinus carpio L.)
Oxidative Stress, Energy Metabolism Disorder, Mitochondrial Damage, and miR-144 Participated in Molecular Mechanisms of 4-Octylphenol-Caused Cardiac Autophagic Damage in Common Carps (Cyprinus carpio L.) Open
Background/Objectives: In 4-octylphenol (4-OP), a toxic environmental pollutant with endocrine disruptive effect, the use of 4-OP causes pollution in the freshwater environment and poses risks to aquatic organisms. Common carps (Cyprinus c…
View article: Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives
Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives Open
Gut microbiota dysbiosis is intricately linked to metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), hyperlipidemia, and non-alcoholic fatty liver disease (NAFLD). Traditional Chinese medicine (TCM), particularly when co…
View article: Screening of Fermentation Conditions for Liver-Protecting Tablets Residues and Their Effect on the Slaughtering Performance of Brolier Chickens
Screening of Fermentation Conditions for Liver-Protecting Tablets Residues and Their Effect on the Slaughtering Performance of Brolier Chickens Open
In order to optimise the solid-state fermentation process of liver tablet dregs and evaluate its feed application value, Bacillus subtilis Bu412 was used as the strain. This was achieved by optimising the water content, temperature, time a…
View article: Unveiling the interplay among skin microbiota, cytokines, and T2DM: an insightful Mendelian randomization study
Unveiling the interplay among skin microbiota, cytokines, and T2DM: an insightful Mendelian randomization study Open
In this study, we found a connection between the skin microbiome and T2DM, with inflammatory cytokines playing a key role in this relationship. This research helps us better understand this complex link and shows that addressing inflammati…
View article: Research on the optimization of mortar mix proportion based on neural network models and genetic algorithm
Research on the optimization of mortar mix proportion based on neural network models and genetic algorithm Open
Strength and durability of concrete are critical performance indicators for the safety and service life of building structures. These properties are significantly influenced by the material proportions and their microstructure. Traditional…
View article: The Nuclear Effector MiISE23 From <i>Meloidogyne incognita</i> Targets JAZ Proteins and Suppresses Jasmonate Signalling, Increasing Host Susceptibility
The Nuclear Effector MiISE23 From <i>Meloidogyne incognita</i> Targets JAZ Proteins and Suppresses Jasmonate Signalling, Increasing Host Susceptibility Open
Meloidogyne incognita is an economically important plant‐parasitic nematode that can infect thousands of different plant species. During its interaction with host plants, M. incognita synthesises numerous effectors in oesophageal glands, w…
View article: Whole-Brain Radiotherapy Simultaneous Integrated Boost Intensity-Modulated Radiotherapy Combined With Anlotinib in the Treatment of Brain Metastases
Whole-Brain Radiotherapy Simultaneous Integrated Boost Intensity-Modulated Radiotherapy Combined With Anlotinib in the Treatment of Brain Metastases Open
Introduction Whole-brain radiotherapy simultaneous integrated boost intensity-modulated radiotherapy (WBRT + SIB-IMRT) is a potential treatment approach for brain metastasis (BM) that may result in improved overall survival (OS). However, …
View article: Achieving Blood Pressure Control Targets Reduces the Risk of Left Bundle Branch Block in Patients With Hypertension
Achieving Blood Pressure Control Targets Reduces the Risk of Left Bundle Branch Block in Patients With Hypertension Open
OBJECTIVE To investigate the impact of different blood pressure control statuses on newly developed left bundle branch block (LBBB). METHODS A retrospective cohort study was conducted. A total of 88,553 Kailuan employees who underwent heal…
View article: Investigating the causal links between obstructive sleep apnea and gastrointestinal diseases mediated by metabolic syndrome through mendelian randomization
Investigating the causal links between obstructive sleep apnea and gastrointestinal diseases mediated by metabolic syndrome through mendelian randomization Open
Previous studies have pointed to a potential link between Obstructive Sleep Apnea (OSA) and gastrointestinal diseases, suggesting that this relationship might be influenced by the presence of Metabolic Syndrome. However, the exact role of …
View article: A new anti-CRISPR gene promotes the spread of drug-resistance plasmids in <i>Klebsiella pneumoniae</i>
A new anti-CRISPR gene promotes the spread of drug-resistance plasmids in <i>Klebsiella pneumoniae</i> Open
The Klebsiella pneumoniae (K. pneumoniae, Kp) populations carrying both resistance-encoding and virulence-encoding mobile genetic elements (MGEs) significantly threaten global health. In this study, we identified a new anti-CRISPR gene (ac…
View article: Level assessment of <sup>87</sup>Rb in rubidium-filled MEMS vapor cells by X-ray imaging for atomic magnetometers
Level assessment of <sup>87</sup>Rb in rubidium-filled MEMS vapor cells by X-ray imaging for atomic magnetometers Open
Quantitative assessments of the level and lifetime of alkali metal in the atomic vapor cells are essential for improving the stability of atomic magnetometers. In this paper, a fast and non-destructive approach is proposed to directly char…
View article: Se Alleviated Pb-Caused Neurotoxicity in Chickens: SPS2-GPx1-GSH-IL-2/IL-17-NO Pathway, Selenoprotein Suppression, Oxidative Stress, and Inflammatory Injury
Se Alleviated Pb-Caused Neurotoxicity in Chickens: SPS2-GPx1-GSH-IL-2/IL-17-NO Pathway, Selenoprotein Suppression, Oxidative Stress, and Inflammatory Injury Open
Lead (Pb), a heavy metal environmental pollutant, poses a threat to the health of humans and birds. Inflammation is one of the most common pathological phenomena in the case of illness and poisoning. However, the underlying mechanisms of i…
View article: Peanut LEAFY COTYLEDON1-type genes participate in regulating the embryo development and the accumulation of storage lipids
Peanut LEAFY COTYLEDON1-type genes participate in regulating the embryo development and the accumulation of storage lipids Open
LEAFY COTYLEDON1 (LEC1) isa member of the nuclear factor Y (NF-Y) family of transcription factors and has been identified as a key regulator of embryonic development. In the present study, two LEC1-type genes from Arachis hypogeae were ide…
View article: Detection of breakage and impurity ratios for raw sugarcane based on estimation model and MDSC-DeepLabv3+
Detection of breakage and impurity ratios for raw sugarcane based on estimation model and MDSC-DeepLabv3+ Open
Broken cane and impurities such as top, leaf in harvested raw sugarcane significantly influence the yield of the sugar manufacturing process. It is crucial to determine the breakage and impurity ratios for assessing the quality and price o…
View article: Molecular Mechanisms of Selenium Mitigating Lead Toxicity in Chickens via Mitochondrial Pathway: Selenoproteins, Oxidative Stress, HSPs, and Apoptosis
Molecular Mechanisms of Selenium Mitigating Lead Toxicity in Chickens via Mitochondrial Pathway: Selenoproteins, Oxidative Stress, HSPs, and Apoptosis Open
Lead (Pb), a hazardous heavy metal, can damage the health of organisms. However, it is not clear whether Pb can damage chicken cerebellums and thalami. Selenium (Se), an essential nutrient for organisms, has a palliative effect on Pb poiso…
View article: Peanut LEAFY COTYLEDON1-type genes participate in regulating the embryo development and accumulation of the storage lipids
Peanut LEAFY COTYLEDON1-type genes participate in regulating the embryo development and accumulation of the storage lipids Open
LEAFY COTYLEDON1 (LEC1) belongs to a member of nuclear factor Y (NF-Y) transcription factors, which has been identified as a key regulator of embryo development. In present study, two LEC1-type genes from Arachis hypogeae were identified a…
View article: Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V<sub>2</sub> Receptor in <i>In Vitro</i>, Ex Vivo, and In Vivo Models of ADPKD
Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V<sub>2</sub> Receptor in <i>In Vitro</i>, Ex Vivo, and In Vivo Models of ADPKD Open
The pharmacological activity of a small-molecule ligand is linked to its receptor residence time. Therefore, precise control of the duration for which a ligand binds to its receptor is highly desirable. Herein, we designed photoswitchable …
View article: Identification Method of Rice Seedlings Rows Based on Gaussian Heatmap
Identification Method of Rice Seedlings Rows Based on Gaussian Heatmap Open
The identification method of rice seedling rows based on machine vision is affected by environmental factors that decrease the accuracy and the robustness of the rice seedling row identification algorithm (e.g., ambient light transformatio…
View article: Input Digitization of the Manufacturing Industry and Carbon Emission Intensity Based on Testing the World and Developing Countries
Input Digitization of the Manufacturing Industry and Carbon Emission Intensity Based on Testing the World and Developing Countries Open
Facing the increasingly deteriorating climate, carbon emission reduction has become a global consensus. In particular, as an industry with very serious pollution emissions, the manufacturing industry is under enormous pressure to reduce en…
View article: The regulatory effect and molecular mechanism of lncRNA Gm10451 on islet cell dysfunction in children with diabetes
The regulatory effect and molecular mechanism of lncRNA Gm10451 on islet cell dysfunction in children with diabetes Open
The dysfunction of islet β- cells is one of the causes of diabetes, and lncRNA Gm10451 is also a participant in the occurrence and the development of various diseases. This study was carried out to reveal the correlation within β- cells an…
View article: Novel classification for simple peripheral arteriovenous malformations based on anatomic localization: Prevalence data from the tertiary referral center in China
Novel classification for simple peripheral arteriovenous malformations based on anatomic localization: Prevalence data from the tertiary referral center in China Open
Background In absence of the large-sample study of simple peripheral arteriovenous malfomations (pAVM), we aimed to perform the epidemiological analysis of over 1,000 simple pAVM patients from our center in the past 5 years, and establish …
View article: Cadmium Accumulation in the Goat Liver and Kidney Is Partially Promoted by the Upregulation of Metal Transporter Genes
Cadmium Accumulation in the Goat Liver and Kidney Is Partially Promoted by the Upregulation of Metal Transporter Genes Open
Metal transporters, including divalent metal-ion transporter-1 (DMT1), Zrt-/Irt-like protein 8 and 14 (ZIP8 and ZIP14), and ferroportin-1 (FPN1), reportedly participate in cellular cadmium (Cd) uptake, but those in farm animals remain uncl…
View article: Genome-wide identification of xyloglucan endotransglucosylase/hydrolase gene family members in peanut and their expression profiles during seed germination
Genome-wide identification of xyloglucan endotransglucosylase/hydrolase gene family members in peanut and their expression profiles during seed germination Open
Seed germination marks the beginning of a new plant life cycle. Improving the germination rate of seeds and the consistency of seedling emergence in the field could improve crop yields. Many genes are involved in the regulation of seed ger…