Explanipedia

Impact of Patent Foramen Ovale on Ischemic Stroke Outcomes in Patients Aged 65 and Older: A Retrospective Cohort Study Open

Nouraldeen Manasrah, Ciara M. Shaver, Rohan Sharma, Samarth Mishra · 2025

T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary Fibrosis Open

Júlia Miranda Ribeiro Bazzano, L Silva, Erin M. Wilfong, Ciara M. Shaver, Lorraine B. Ware , et al. · 2025

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and respiratory failure, with a median survival of 3–5 years. While T-cell numbers are elevated in IPF lungs, their contribution…

Early institutional experience with third-party procurement in lung transplantation—an observational pilot study Open

Caitlin T. Demarest, JOHN H. STOKES, Arvind J. Trindade, Ciara M. Shaver, D Erasmus , et al. · 2025

Matrix metalloproteinase-7 is dispensable in a mouse model of sepsis-induced acute lung injury Open

Brandon Baer, Jason Lin, Kaitlyn Schaaf, Lorraine B. Ware, Ciara M. Shaver , et al. · 2025

Acute respiratory distress syndrome (ARDS) is a life-threatening form of acute lung injury whose pathogenesis is characterized by excessive lung inflammation and alveolar-capillary barrier permeability. Matrix metalloproteinase 7 (MMP7) ca…

Oxidized Cell‐Free Hemoglobin Induces Mitochondrial Dysfunction by Activation of the Mitochondrial Permeability Transition Pore in the Pulmonary Microvasculature Open

Kyle Riedmann, Jamie E. Meegan, Aqeela Afzal, Yatzil Cervantes‐Cruz, S. Obeidalla , et al. · 2025

Objective Cell‐free hemoglobin (CFH) is released into the circulation during sepsis where it can redox cycle from the ferrous 2+ to ferric 3+ and disrupt endothelial function, but the mechanisms of CF‐mediated endothelial dysfunction are u…

10 degree C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia-reperfusion injury Open

Kaitlyn M. Tracy, Yutaka Shishido, Mark Petrovic, Alexandria C. Murphy, TiOluwanimi Adesanya , et al. · 2025

Lung rehabilitation using xenogeneic cross-circulation does not lead to hyperacute rejection in a human lung transplantation model Open

Kaitlyn M. Tracy, Timothy R Harris, Mark Petrovic, Michael Cortelli, William Tucker , et al. · 2025

Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis Open

Annika Vannan, Ruqian Lyu, Arianna L. Williams-Katek, Nicholas M. Negretti, Evan D. Mee , et al. · 2025

Association of Grit and Resilience With Short‐Term Post‐Transplant Outcomes in Lung Allograft Recipients Open

Alexander G. Dragnich, Kaitlyn C. Chapin, Ke Xu, Jinyuan Liu, Loren Lipworth , et al. · 2025

The importance of mental toughness on lung transplant outcomes is unknown. We performed a pilot study to assess whether pretransplant grit and resilience are associated with short‐term posttransplant outcomes. We enrolled 31 lung transplan…

Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx Open

Kaitlyn Schaaf, Stuart R. Landstreet, Nathan D. Putz, Samantha Gonski, Jason Lin , et al. · 2024

Background The alveolar epithelium is protected by a heparan sulfate-rich, glycosaminoglycan layer called the epithelial glycocalyx. It is cleaved in patients with acute respiratory distress syndrome (ARDS) and in murine models of influenz…

Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report Open

Rebecca F. Hough, Cristina M. Alvira, Julie A. Bastarache, Serpil C. Erzurum, Wolfgang M. Kuebler , et al. · 2024

Lung endothelium resides at the interface between the circulation and the underlying tissue, where it senses biochemical and mechanical properties of both the blood as it flows through the vascular circuit and the vessel wall. The endothel…

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis Open

Yoshihiro Hasegawa, Jennifer M. Franks, Yusuke Tanaka, Yasuaki Uehara, David F. Read , et al. · 2024

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored mechanisms of silica-induced pulmonary fibrosis in human lung samples collecte…

Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies Open

Avery M. Bogart, Christine R. Lopez, S. Obeidalla, C. Wang, Andrew Willmore , et al. · 2024

Elevated HbA1c may be associated with risk of developing ARDS, independent of clinical diagnosis of diabetes, but prospective validation is needed. If confirmed, these findings suggest that inadequate glycemic control could be an unrecogni…

Author Correction: Cell-type-specific and disease-associated expression quantitative trait loci in the human lung Open

Heini M. Natri, Christina B. Azodi, Lance Peter, Chase J. Taylor, Sagrika Chugh , et al. · 2024

eQTLs that were nominally significant (P < 1 × 10 -6 ) in the IPF GWAS meta-analysis" and has now been corrected in the HTML and PDF versions of the article.

Pulmonary vascular disease in Veterans with post-deployment respiratory syndrome Open

Sergey Gutor, Bradley W. Richmond, Vineet Agrawal, Evan L. Brittain, Ciara M. Shaver , et al. · 2024

Exertional dyspnea has been documented in US military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We pe…

Cell-type-specific and disease-associated expression quantitative trait loci in the human lung Open

Heini M. Natri, Christina B. Azodi, Lance Peter, Chase J. Taylor, Sagrika Chugh , et al. · 2024

Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the…

The Emperor Has Some Clothes: Emerging Molecular Diagnostics in Post–Lung Transplant Decision-Making Open

Daniel R. Calabrese, Ciara M. Shaver · 2024

Risk factors and clinical consequences of early extubation failure in lung transplant recipients Open

Kaitlyn C. Chapin, Alexander G. Dragnich, Whitney D. Gannon, Abigail K. Martel, Matthew Bacchetta , et al. · 2023

Specific baseline donor and recipient demographics and intraoperative variables are associated with greater risk for post-transplant extubation failure. Patients with extubation failure have worse short-term outcomes.

Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis Open

Annika Vannan, Ruqian Lyu, A. Williams, Nicholas M. Negretti, Evan D. Mee , et al. · 2023

The human lung is structurally complex, with a diversity of specialized epithelial, stromal and immune cells playing specific functional roles in anatomically distinct locations, and large-scale changes in the structure and cellular makeup…

Outcomes of lung transplantation from donors with hepatitis C viremia with outpatient initiation of antiviral therapy Open

Ciara M. Shaver, Jinyuan Liu, Ke Xu, Gong Yang, Madeline C. Morrison , et al. · 2023

Transplantation of lungs from donors with active hepatitis C viremia with early initiation of antiviral therapy has been shown to have similar short- and medium-term outcomes compared to transplantation of lungs from nonviremic donors. Con…

Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88 Open

Kaitlyn Schaaf, Stuart R. Landstreet, Sangami Pugazenthi, Emily Y. Qian, Nathan D. Putz , et al. · 2023

Cell-free hemoglobin (CFH) is elevated in the airspace of most patients with acute respiratory distress syndrome and causes severe inflammation. Here, we identify that CFH contributes to macrophage-induced cytokine production via Toll-like…

<i>MICB</i> Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death Open

Oscar A. Aguilar, Anita Qualls, Maria D. R. Gonzalez-Hinojosa, S. Obeidalla, V. Eric Kerchberger , et al. · 2023

Rationale: Acute lung injury (ALI) carries a high risk of mortality but has no established pharmacologic therapy. We previously found that experimental ALI occurs through natural killer (NK) cell NKG2D receptor activation and that t…

Immune recognition of porcine organs transplanted into humans Open

Ciara M. Shaver, Matthew Bacchetta · 2023

Devil is in the airspace: compartmentalisation of inflammation during COVID ARDS Open

Ciara M. Shaver · 2023

Relative Change in Donor-Derived Cell-free DNA is Superior to Absolute Values for Diagnosis of Acute Lung Allograft Dysfunction Open

Anil J. Trindade, Kaitlyn C. Chapin, Jennifer N. Gray, Y. Furuya, Amy Mullican , et al. · 2023

Background. Donor-derived cell-free DNA (dd-cfDNA%) is a biomarker of early acute lung allograft dysfunction (ALAD), with a value of ≥1.0% indicating injury. Whether dd-cfDNA% is a useful biomarker in patients >2 y posttransplant is unknow…

Pulmonary Vascular Disease in Veterans with Post-Deployment Respiratory Syndrome Open

Sergey Gutor, Bradley W. Richmond, Vineet Agrawal, Evan L. Brittain, Matthew F. Mart , et al. · 2023

Background Increased frequency of exertional dyspnea has been documented in U.S. military personnel after deployment to Southwest Asia and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associate…

Scientific Program Committee Open

Howard J. Eisen, Andreas Zuckermann, Laurie D. Snyder, Göran Dellgren, A. Velleca , et al. · 2023

Immune characterization of a xenogeneic human lung cross-circulation support system Open

Wei Wu, Matthew T. Stier, John W. Stokes, Rei Ukita, Yatrik J. Patel , et al. · 2023

Improved approaches to expanding the pool of donor lungs suitable for transplantation are critically needed for the growing population with end-stage lung disease. Cross-circulation (XC) of whole blood between swine and explanted human lun…

Cell type-specific and disease-associated eQTL in the human lung Open

Heini M. Natri, Christina B. Azodi, Lance Peter, Chase J. Taylor, Sagrika Chugh , et al. · 2023

Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis (PF). Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understandin…

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis Open

Yoshihiro Hasegawa, Jennifer M. Franks, Yusuke Tanaka, Yasuaki Uehara, David F. Read , et al. · 2023

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored the mechanisms of silica-induced pulmonary fibrosis in a mouse model using mul…

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