Christopher M. O’Connor
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View article: Impact of standardized team‐based care on cardiogenic shock outcomes over time
Impact of standardized team‐based care on cardiogenic shock outcomes over time Open
Background and Aims Limited data exist regarding the impact of standardized care on cardiogenic shock (CS) outcomes over time. We aimed to investigate the influence of multidisciplinary management on CS outcomes following implementation of…
View article: Vericiguat and mortality in heart failure and reduced ejection fraction: the VICTOR trial
Vericiguat and mortality in heart failure and reduced ejection fraction: the VICTOR trial Open
Background and Aims In the VICTOR trial (NCT05093933), vericiguat was neutral for the primary composite endpoint of cardiovascular death or hospitalization for heart failure (HF). VICTOR was powered to independently assess cardiovascular d…
View article: 6 ‘A gut instinct’: tackling <i>Clostridioides difficile</i> infection in surgical patients
6 ‘A gut instinct’: tackling <i>Clostridioides difficile</i> infection in surgical patients Open
Introduction Clostridioides difficile infection (CDI) is a leading healthcare-associated infection, ranging from mild diarrhoea to severe colitis with toxic megacolon, pseudomembranous colitis, and death. Surgical patients are particularly…
View article: PO-llution control: a cross-sectional study on the role of antimicrobial stewardship in reducing healthcare’s carbon footprint
PO-llution control: a cross-sectional study on the role of antimicrobial stewardship in reducing healthcare’s carbon footprint Open
Objectives To evaluate the environmental impact of prolonged IV antimicrobial courses and identify opportunities for improved antimicrobial stewardship (AMS) practices. Methods A retrospective cross-sectional study was conducted using AMS …
View article: Use of Radiomics to Predict Pancreatic Neuroendocrine Tumor Aggressiveness: A Novel and Personalized Approach to Patients with Multiple Endocrine Neoplasia Type 1 Disease
Use of Radiomics to Predict Pancreatic Neuroendocrine Tumor Aggressiveness: A Novel and Personalized Approach to Patients with Multiple Endocrine Neoplasia Type 1 Disease Open
Background Multiple Endocrine Neoplasia Type 1 (MEN1) is an autosomal dominant disorder that predisposes individuals to endocrine tumours, including pancreatic neuroendocrine tumours (PNETs), which range from indolent to metastatic. Liver …
View article: Derisking Phase II Clinical Trials in Heart Failure
Derisking Phase II Clinical Trials in Heart Failure Open
Phase II clinical trials play an important role in drug development, providing key data that guide decision-making for promising therapeutic candidates. An important objective of phase II is to establish proof of concept by demonstrating t…
View article: Assessing Benefit in Heart Failure Patients with Reduced Ejection Fraction: Analysis of the VICTORIA Trial Using Novel Prognostic Risk Stratification
Assessing Benefit in Heart Failure Patients with Reduced Ejection Fraction: Analysis of the VICTORIA Trial Using Novel Prognostic Risk Stratification Open
Background Randomized controlled clinical trials remain the gold standard for determining efficacy of new heart failure (HF) therapies; however, failure to account for heterogeneity in risk of the primary endpoint(s) may dilute treatment e…
View article: Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure
Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure Open
Perturbations in kidney function are frequently encountered in heart failure (HF) across its spectrum in both chronic and acute settings with distinct implications for patient management and prognosis. Lack of consensus on the threshold fo…
View article: Artificial Intelligence in Cardiovascular Clinical Trials
Artificial Intelligence in Cardiovascular Clinical Trials Open
Randomized clinical trials are the gold standard for establishing the efficacy and safety of cardiovascular therapies. However, current pivotal trials are expensive, lengthy, and insufficiently diverse. Emerging artificial intelligence (AI…
View article: Optimal Medical Therapy and Outcomes Among Patients With Chronic Heart Failure With Reduced Ejection Fraction
Optimal Medical Therapy and Outcomes Among Patients With Chronic Heart Failure With Reduced Ejection Fraction Open
Optimal medical therapy (OMT) scoring may stratify clinical risk in real-world chronic heart failure with reduced ejection fraction (HFrEF) by integrating use and dosing of guideline-directed medical therapy (GDMT) for HFrEF. The purpose o…
View article: Heart Failure Drug Development Over the Eras
Heart Failure Drug Development Over the Eras Open
Over the past decade, the field of heart failure (HF) has witnessed remarkable progress in drug development, resulting in the approval of numerous groundbreaking drugs by the U.S. Food and Drug Administration. To address some of these chal…
View article: Evaluation of the Hemocompatibility of the Direct Oral Anticoagulant Apixaban in Left Ventricular Assist Devices
Evaluation of the Hemocompatibility of the Direct Oral Anticoagulant Apixaban in Left Ventricular Assist Devices Open
Anticoagulation with apixaban was feasible in patients with an LVAD without an excess of HRAEs or deaths. This study informs future pivotal clinical trials evaluating the safety and efficacy of apixaban in LVAD recipients. (Evaluation of t…
View article: Antimicrobial prescribing in acute pancreatitis: Too much for too many?
Antimicrobial prescribing in acute pancreatitis: Too much for too many? Open
Background: Acute pancreatitis (AP) is an inflammatory condition of the pancreas that varies widely in both clinical presentation and severity. Current international guidelines do not recommend the use of prophylactic antimicrobials in AP.…
View article: Diet and physical activity interventions to improve cardiovascular disease risk factors in liver transplant recipients: Systematic review and meta-analysis
Diet and physical activity interventions to improve cardiovascular disease risk factors in liver transplant recipients: Systematic review and meta-analysis Open
Diet and physical activity interventions reduced percentage body fat and triglycerides in liver transplant recipients. Further good quality research is needed to evaluate their effect on other cardiovascular disease risk factors, including…
View article: Diuretic Use and Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from the VICTORIA Trial
Diuretic Use and Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from the VICTORIA Trial Open
Aims In VICTORIA, vericiguat compared with placebo reduced the risk of cardiovascular death (CVD) and heart failure hospitalization (HFH) in patients enrolled after a worsening heart failure (WHF) event. We examined clinical outcomes and e…
View article: Getting to the heart of the matter—are two agents really better than one for the treatment of staphylococcal infective endocarditis?
Getting to the heart of the matter—are two agents really better than one for the treatment of staphylococcal infective endocarditis? Open
The recently published European Society of Cardiology guidelines for infective endocarditis management recommends daptomycin combination therapy for the treatment of staphylococcal endocarditis in severe penicillin allergy, rather than dap…
View article: Biomarker profiles of favorable ventricular remodeling in heart failure patients with reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial
Biomarker profiles of favorable ventricular remodeling in heart failure patients with reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial Open
Background Favorable ventricular remodeling, defined as a decrease in left ventricular end-systolic volume indexed (LVESVI) to body surface area or an increase in left ventricular ejection fraction (LVEF), is associated with improved clini…
View article: USING REVERSE NOISE CONTOURS TO MANAGE CONSTRUCTION NOISE - A CONTRACTOR'S EXPERIENCE
USING REVERSE NOISE CONTOURS TO MANAGE CONSTRUCTION NOISE - A CONTRACTOR'S EXPERIENCE Open
At a time when the demand to extend the life of existing infrastructure is high, the challenge of managing the noise impact of construction works in urban environments needs fresh thinking.The upgrade of one of London's busiest underground…
View article: A comparative analysis of microglial inducible Cre lines
A comparative analysis of microglial inducible Cre lines Open
Cre/loxP technology has revolutionized genetic studies and allowed for spatial and temporal control of gene expression in specific cell types. Microglial biology has particularly benefited because microglia historically have been difficult…
View article: Evolution of NT-proBNP During Prerandomization Screening in VICTORIA: Implications for Clinical Outcomes and Efficacy of Vericiguat
Evolution of NT-proBNP During Prerandomization Screening in VICTORIA: Implications for Clinical Outcomes and Efficacy of Vericiguat Open
BACKGROUND: Selecting high-risk patients with heart failure with potentially modifiable cardiovascular events is a priority. Our objective was to evaluate NT-proBNP (N-terminal pro-B-type natriuretic peptide) changes during a 30-day screen…