Ciara O’Donnell
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View article: Sugammadex or Neostigmine for prevention of post-operative pulmonary complications after major abdominal or thoracic surgery: study protocol for the SINFONIA (Sugammadex for preventioN oF pOst-operative pulmonary complIcAtions) randomised controlled superiority trial
Sugammadex or Neostigmine for prevention of post-operative pulmonary complications after major abdominal or thoracic surgery: study protocol for the SINFONIA (Sugammadex for preventioN oF pOst-operative pulmonary complIcAtions) randomised controlled superiority trial Open
Background Post-operative pulmonary complications (PPCs) are an important source of morbidity and mortality after major abdominal and thoracic surgery. The use of neuromuscular blocking drugs in general anaesthesia is an important risk fac…
View article: When Collaboration Falters, Insensitivity to How Our Actions Affect Others Drives Inflated Self-evaluations
When Collaboration Falters, Insensitivity to How Our Actions Affect Others Drives Inflated Self-evaluations Open
During high-stake interactions, people not only evaluate policies or outcomes, but also themselves and others. Such evaluations may be crucial for long-term outcomes, such as harmonious marriage, confident leadership and indeed mental heal…
View article: Author Correction: The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors
Author Correction: The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors Open
Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-022-21053-2, published online 05 October 2022. The original version of this Article contained an omission in the Methods section, under the subheading ‘Risk factors’. “A detai…
View article: Protocol for the economic evaluation of group interpersonal therapy for postnatal depression compared with high-quality standard care in Kenya and Lebanon (SUMMIT trial)
Protocol for the economic evaluation of group interpersonal therapy for postnatal depression compared with high-quality standard care in Kenya and Lebanon (SUMMIT trial) Open
Introduction One in six women experience postnatal depression globally. Treatment is often unavailable, which increasing risks of long-term depression among mothers and poorer developmental outcomes for their children. This protocol outli…
View article: Human adolescent brain similarity development is different for paralimbic versus neocortical zones
Human adolescent brain similarity development is different for paralimbic versus neocortical zones Open
Adolescent development of human brain structural and functional networks is increasingly recognized as fundamental to emergence of typical and atypical adult cognitive and emotional processes. We analysed multimodal magnetic resonance imag…
View article: Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia
Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia Open
We used a probabilistic reversal learning task to examine prediction error-driven belief updating in three clinical groups with psychosis or psychosis-like symptoms. Study 1 compared people with at-risk mental state and first episode psych…
View article: Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial
Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial Open
Background Depression ranks as the foremost mental health concern among childbearing women. Within low- and middle-income countries (LMICs), between 20 and 25% of women encounter depression during pregnancy or soon after delivery. This con…
View article: Cohort Profile Update: The Neuroscience in Psychiatry Network (NSPN) 2400 cohort during the COVID-19 pandemic
Cohort Profile Update: The Neuroscience in Psychiatry Network (NSPN) 2400 cohort during the COVID-19 pandemic Open
The Neuroscience in Psychiatry Network (NSPN) 2400 cohort (n 2403; aged 14-24 years at baseline) was conceived in 2012 to support an accelerated longitudinal design to study the emergence of psychopathology and psychiatric disorders across…
View article: P62 The environmental impact of skin cancer surgery
P62 The environmental impact of skin cancer surgery Open
The climate crisis has been described as the greatest global health threat by the World Health Organization. In 2019, healthcare-related emissions accounted for 25 mega-tonnes CO2 equivalent (CO2e), 10% of which was related to staff and pa…
View article: Reducing the treatment burden of keratinocyte cancers requiring referral to plastic surgery: Lessons from lockdown
Reducing the treatment burden of keratinocyte cancers requiring referral to plastic surgery: Lessons from lockdown Open
Background Keratinocyte cancers are increasing in incidence in Ireland and are more common in older age, necessitating multidisciplinary specialist input and treatment often is a greater burden for patients. The coronavirus disease 2019 (C…
View article: Human Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor
Human Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection…
View article: SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain (NTD) remains poorly characterized despite enrichment of mutations in this region across variants of concern (VOCs). Here, we examine the contribution…
View article: Adolescent development of multiscale structural wiring and functional interactions in the human connectome
Adolescent development of multiscale structural wiring and functional interactions in the human connectome Open
Adolescence is a time of profound changes in the physical wiring and function of the brain. Here, we analyzed structural and functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y ( n = 199). Core to…
View article: Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning
Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning Open
Compulsive behavior is enacted under a belief that a specific act controls the likelihood of an undesired future event. Compulsive behaviors are widespread in the general population despite having no causal relationship with events they as…
View article: What is the impact of dexamethasone on postoperative pain in adults undergoing general anaesthesia for elective abdominal surgery: a systematic review and meta-analysis
What is the impact of dexamethasone on postoperative pain in adults undergoing general anaesthesia for elective abdominal surgery: a systematic review and meta-analysis Open
Background Previous meta-analysis of heterogeneous surgical cohorts demonstrated reduction in postoperative pain with perioperative intravenous dexamethasone, but none have addressed adults undergoing elective abdominal surgery. Objective …
View article: An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization
An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization Open
Adolescence is a critical time for the continued maturation of brain networks. Here, we assessed structural connectome development in a large longitudinal sample ranging from childhood to young adulthood. By projecting high-dimensional con…
View article: Author response: An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization
Author response: An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Adolescence is a critical time for the con…
View article: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies Open
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries. It is unclear whether the…
View article: Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity
Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity Open
Significance Goal-directed behavior is impaired in disorders of compulsivity. Here, we characterize the developmental trajectory of model-based control and show a progressive strengthening from adolescence to early adulthood. We found that…