Health Research Board, Cancer Research UK, Irish Cancer Society, Oesophageal Cancer Fund, and French National Cancer Institute.

Abstract Background While PET-CT is considered the gold standard imaging investigation in diagnosing esophageal cancer, its role in determining management is controversial. It demonstrates increased sensitivity for detection of occult M1 disease in comparison with endosonography or CT alone, however its accuracy in assessment of histopathologic response to neoadjuvant therapy is unclear. The aim of this study was to evaluate the clinical utility of PET-CT in staging, response evaluation and prognostication in esop…

A digital twin is a digital representation of a real-world object synchronized at a specified periodicity and fidelity. The original concept emerged decades ago, based on ideas that first arose in science fiction and in the Apollo program [1].

Prostate cancer is the most common malignancy in men with high incidence of recurrence following treatment. Biochemical recurrence, as indicated by rising PSA levels following successful treatment of the primary disease, is a frequent encounter in routine clinical practice. 68 Gallium-PSMA positron emission tomography/computer tomography has been widely accepted as the modality of choice with the highest impact in management of this group of patients. Pitfalls of this diagnostic technique stem from the diversity o…

Positron Emission Tomography (PET) is a functional imaging modality widely used in clinical oncology. Over the years the sensitivity and specificity of PET has improved with the advent of specific radiotracers, increased technical accuracy of PET scanners and incremental experience of Radiologists. However, significant limitations exist—most notably false positives and false negatives. Additionally, the accuracy of PET varies between cancer types and in some cancers, is no longer considered a standard imaging moda…