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View article: Agreement between clinical criteria and quantitative polymerase chain reaction for diagnosing scabies in Auckland children
Agreement between clinical criteria and quantitative polymerase chain reaction for diagnosing scabies in Auckland children Open
Aim We sought to determine the degree of agreement between clinical and laboratory methods for diagnosing scabies in school‐aged children. Methods Clinical information and samples were collected from children aged 7 months to 14 years atte…
Comparison of prevalence estimates of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum determined by conventional PCR and multiplex qPCR and implications for surveillance and monitoring Open
Multiplex qPCR and cPCR produce comparable estimates of gene deletion prevalence when monoclonal infections dominate; however, qPCR provides higher estimates where multi-clonal infections are common.
Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda Open
Background Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda, but deletion of the pfhrp2/3 target gene threatens their usefulness as malaria diagnosis and s…
A cross-sectional survey of knowledge and attitudes towards scabies control in Australian aged care facilities Open
Scabies outbreaks cause significant morbidity and disruption in aged care facilities and other institutional settings. Failure to manage scabies outbreaks may be attributable to low awareness amongst healthcare workers. A survey was distri…
View article: Children's scabies survey indicates high prevalence and misdiagnosis in Auckland educational institutions
Children's scabies survey indicates high prevalence and misdiagnosis in Auckland educational institutions Open
Aim Here, we present results of a survey of scabies prevalence in childcare centres and primary schools in Auckland. Methods Children whose parents agreed to take part in participating centres in the Auckland region were examined for scabi…
Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility 1 of HRP2-based malaria RDTs in Northern Uganda Open
Background: Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda however deletion of the pfhrp2/3 target gene threatens their usefulness as malaria diagnosis a…
High prevalence of scabies in Auckland pre-schools Open
The prevalence of scabies is high in early childcare centres in socio-economically challenged areas of Auckland.
Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome Open
Background The suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic studies. Additionally, parasitologic diagnosis by microscopic examinat…
Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia Open
The studies were registered with the Australian New Zealand Clinical Trials Registry: ACTRN12617000244303 (https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372357) and ACTRN12617001394336 (https://www.anzctr.org.au/Trial/Re…
Polymorphisms in Plasmodium falciparum Kelch 13 and P. vivax Kelch 12 Genes in Parasites Collected from Three South Pacific Countries Prior to Extensive Exposure to Artemisinin Combination Therapies Open
The South Pacific countries Solomon Islands, Vanuatu, and Papua New Guinea (PNG) adopted artemisinin-based combination therapies (ACTs) in 2008. We examined Kelch 13 and Kelch 12 genes in parasites originating from these countries before o…
Cyclooctatetraene: A Bioactive Cubane Paradigm Complement Open
Cubane was recently validated as a phenyl ring (bio)isostere, but highly strained caged carbocyclic systems lack π character, which is often critical for mediating key biological interactions. This electronic property restriction associate…
View article: CCDC 1847176: Experimental Crystal Structure Determination
CCDC 1847176: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 1847177: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 1847178: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial Open
Large-scale in vitro culture of P. falciparum parasites using a wave bioreactor can be achieved under GMP-compliant conditions. This provides a cost-effective methodology for the production of malaria parasites suitable for administration …
View article: Corrigendum: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere
Corrigendum: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere Open
In this Communication, a La Trobe University affiliation is missing for the author David A. Winkler. The penultimate author address entry must read: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 (Australia…
Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission Open
Anzctr.org.au ACTRN12613001008718.
View article: The Utility of Malaria Rapid Diagnostic Tests as a Tool in Enhanced Surveillance for Malaria Elimination in Vanuatu
The Utility of Malaria Rapid Diagnostic Tests as a Tool in Enhanced Surveillance for Malaria Elimination in Vanuatu Open
PCD and Pro-ACDs demonstrate that both Tafea and Torba Provinces in Vanuatu has achieved very low malaria prevalence. In these low-transmission areas, conducting Pro-ACD and Re-ACDs using RDTs appears not cost-effective and may have limite…
Piperaquine Monotherapy of Drug-Susceptible<i>Plasmodium falciparum</i>Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia Open
ACTRN12613000565741.
Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere Open
Bioisosteres In their Communication on page 3580 ff., C. M. Williams, G. P. Savage, J. Tsanaktsidis et al. confirm that cubane can act as a benzene bioisostere by synthesizing and evaluating cubane derivatives of five biologically importan…
Frontispiz: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere Open
Bioisosterie In ihrer Zuschrift auf S. 3644 ff. bestätigen C. M. Williams, G. P. Savage, J. Tsanaktsidis et al. durch die Synthese und Evaluierung von Cuban-Derivaten fünf biologisch wichtiger Verbindungen, dass Cuban und Benzol bioisoster…
Sensitive Detection of Plasmodium vivax Using a High-Throughput, Colourimetric Loop Mediated Isothermal Amplification (HtLAMP) Platform: A Potential Novel Tool for Malaria Elimination Open
This novel HtLAMP-P. vivax assay has the potential to be a useful field applicable molecular diagnostic test for P. vivax infection in elimination settings.
Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere Open
Pharmaceutical and agrochemical discovery programs are under considerable pressure to meet increasing global demand and thus require constant innovation. Classical hydrocarbon scaffolds have long assisted in bringing new molecules to the m…
CCDC 1418507: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 1418506: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …