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View article: Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy
Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy Open
Objective This is a cross-sectional study to evaluate whether β-amyloid-(Aβ)-PET positivity and cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA) are regionally colocalized. Methods Ten patients with p…
View article: Detection Gap of Right-Asymmetric Neuronal Degeneration by CERAD Test Battery in Alzheimer’s Disease
Detection Gap of Right-Asymmetric Neuronal Degeneration by CERAD Test Battery in Alzheimer’s Disease Open
Objectives : Asymmetric disease characteristics on neuroimaging are common in structural and functional imaging of neurodegenerative diseases, particularly in Alzheimer‘s disease (AD). However, a standardized clinical evaluation of asymmet…
View article: Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study Open
In patients with FTD, the education level predicts the existing left temporal FDG-PET hypometabolism at the same cognition level, supporting the cognitive reserve hypothesis in FTD.
View article: Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA
Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA Open
Cortical superficial siderosis (cSS) is a common feature in patients with cerebral amyloid angiopathy (CAA). The correlation between β-amyloid and/or tau pathology and the occurrence of cSS is unclear. We report on an 80-year-old male pati…
View article: Basal forebrain atrophy along the Alzheimer’s disease spectrum and its relevance for subjective cognitive decline
Basal forebrain atrophy along the Alzheimer’s disease spectrum and its relevance for subjective cognitive decline Open
Background There is growing evidence in the literature that the cholinergic basal forebrain might be one of the earliest affected structures in Alzheimer’s disease (AD). Recent data suggest that individuals with preclinical Alzheimer’s pat…
View article: Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status
Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status Open
Background: While cerebral beta-amyloid accumulation was found in many studies to alter precuneus-based functional connectivity (FC) in mild cognitive impairment and demented Alzheimer’s disease (AD) patients, its impact is less well under…
View article: Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies
Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies Open
Background Striatal dopamine deficiency and metabolic changes are well‐known phenomena in dementia with Lewy bodies and can be quantified in vivo by 123 I‐Ioflupane brain single‐photon emission computed tomography of dopamine transporter a…
View article: Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer’s Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness
Multicenter Tract-Based Analysis of Microstructural Lesions within the Alzheimer’s Disease Spectrum: Association with Amyloid Pathology and Diagnostic Usefulness Open
Diffusion changes as determined by diffusion tensor imaging are potential indicators of microstructural lesions in people with mild cognitive impairment (MCI), prodromal Alzheimer's disease (AD), and AD dementia. Here we extended the scope…
View article: P1‐407: RELATIONSHIP BETWEEN GLOBAL CONNECTIVITY, AMYLOID AND TAU IN DIFFERENT STAGES DURING THE DEVELOPMENT OF ALZHEIMER'S DISEASE AS DEMONSTRATED IN THE DZNE DELCODE COHORT
P1‐407: RELATIONSHIP BETWEEN GLOBAL CONNECTIVITY, AMYLOID AND TAU IN DIFFERENT STAGES DURING THE DEVELOPMENT OF ALZHEIMER'S DISEASE AS DEMONSTRATED IN THE DZNE DELCODE COHORT Open
Recent multicenter studies provide rich insights in restingstate alterations, while different scanning protocols between sites sometimes lower interpretability (Teipel et al., 2017a, 2017b). Global brain connectivity (GBC) is a local resti…
View article: Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis Open
Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS…
View article: Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy
Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy Open
Patients with cSS and suspected CAA are at high risk for CAA-related incident intracranial hemorrhage and poor functional outcome. Both the presence and extent of cSS have prognostic relevance and may influence clinical decision-making.
View article: Correspondence Between Resting-State and Episodic Memory-Task Related Networks in Elderly Subjects
Correspondence Between Resting-State and Episodic Memory-Task Related Networks in Elderly Subjects Open
Resting-state fMRI studies demonstrated temporally synchronous fluctuations in brain activity among ensembles of brain regions, suggesting the existence of intrinsic functional networks. A spatial match between some of the resting-state ne…
View article: Clinical Routine FDG-PET Imaging of Suspected Progressive Supranuclear Palsy and Corticobasal Degeneration: A Gatekeeper for Subsequent Tau-PET Imaging?
Clinical Routine FDG-PET Imaging of Suspected Progressive Supranuclear Palsy and Corticobasal Degeneration: A Gatekeeper for Subsequent Tau-PET Imaging? Open
Background: F-18-fluordeoxyglucose positron emission tomography (FDG-PET) is widely used for discriminative diagnosis of tau-positive atypical parkinsonian syndromes (T+APS). This approach now stands to be augmented with more specific tau …
View article: Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer’s Disease
Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer’s Disease Open
Even when following a strictly harmonized data acquisition protocol and rigorous scan quality control, widely used connectivity measures of multicenter rs-fMRI do not reach levels of diagnostic accuracy sufficient for a useful biomarker in…
View article: The left frontal cortex supports reserve in aging by enhancing functional network efficiency
The left frontal cortex supports reserve in aging by enhancing functional network efficiency Open
The present results suggest that higher education-related LFC connectivity to key memory networks during a memory task is associated with higher network efficiency and thus enhanced reserve of memory abilities in aging.
View article: Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease
Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease Open
Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may support higher reserve capacity, i.e. relatively high cognitive …
View article: Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment
Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment Open
Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer's disease. A putative functional neural substrate underlying reserve is global functional connectivity …
View article: Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment
Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment Open
Reserve in aging and Alzheimer's disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors. Recent evidence …
View article: [IC‐P‐119]: CROSS‐NETWORK COUPLING OF THE FRONTOPARIETAL CONTROL NETWORK DURING MEMORY PERFORMANCE SUPPORTS PROTECTIVE EFFECTS OF EDUCATION IN AGING
[IC‐P‐119]: CROSS‐NETWORK COUPLING OF THE FRONTOPARIETAL CONTROL NETWORK DURING MEMORY PERFORMANCE SUPPORTS PROTECTIVE EFFECTS OF EDUCATION IN AGING Open
Individuals with higher education have a lower risk of developing cognitive decline or Alzheimer's disease dementia at late age, suggesting that education is associated with enhanced reserve in late-life that helps maintaining memory and o…