Cilia R. Pothast
YOU?
Author Swipe
View article: Humoral and cellular immune response after COVID-19 vaccination in patients with sickle cell disease on hydroxyurea
Humoral and cellular immune response after COVID-19 vaccination in patients with sickle cell disease on hydroxyurea Open
Patients with sickle cell disease (SCD) are at increased risk of COVID-19-related mortality compared to healthy individuals, also after vaccination. To what extent impaired vaccine-induced immunity contributes to this risk is unknown. We p…
View article: Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses Open
The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination. Understanding its functional capacity is crucial for deciphering correlates of …
View article: T-cell and antibody responses in immunocompromised patients with hematologic malignancies indicate strong potential of SARS-CoV-2 mRNA vaccines
T-cell and antibody responses in immunocompromised patients with hematologic malignancies indicate strong potential of SARS-CoV-2 mRNA vaccines Open
Not available.
View article: Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C Open
T cell recognition of specific antigens presented by major histocompatibility complexes class-I (MHC-I) can play an important role during immune responses against pathogens and cancer cells. Detection of T cell immunity is based on assessi…
View article: Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C Open
T cell recognition of specific antigens presented by major histocompatibility complexes class-I (MHC-I) can play an important role during immune responses against pathogens and cancer cells. Detection of T cell immunity is based on assessi…
View article: Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses Open
The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination. Understanding its functional capacity is crucial for deciphering correlates of …
View article: Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C Open
T cell recognition of specific antigens presented by major histocompatibility complexes class-I (MHC-I) can play an important role during immune responses against pathogens and cancer cells. Detection of T cell immunity is based on assessi…
View article: Immune responses to SARS-CoV-2 in sub-Saharan Africa and western Europe: a retrospective, population-based, cross-sectional study
Immune responses to SARS-CoV-2 in sub-Saharan Africa and western Europe: a retrospective, population-based, cross-sectional study Open
European and Developing Countries Clinical Trials Partnership 2 programme (AIDCO), LUMC Gisela Thier Fellowship, Dutch Research Council (NWO), European Research Council, and Leids Universitair Fonds.
View article: Intradermal delivery of the third dose of the mRNA-1273 SARS-CoV-2 vaccine: safety and immunogenicity of a fractional booster dose
Intradermal delivery of the third dose of the mRNA-1273 SARS-CoV-2 vaccine: safety and immunogenicity of a fractional booster dose Open
View article: Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial
Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial Open
Fractional dosing can be a cost-effective vaccination strategy to accelerate individual and herd immunity in a pandemic. We assessed the immunogenicity and safety of primary intradermal (ID) vaccination, with a 1/5th dose compared with the…
View article: P1536: SARS-COV-2 INFECTIONS IN PATIENTS WITH HAEMATOLOGIC MALIGNANCIES: EFFECT OF VACCINATION AND THE DEVELOPMENT OF HYBRID IMMUNITY
P1536: SARS-COV-2 INFECTIONS IN PATIENTS WITH HAEMATOLOGIC MALIGNANCIES: EFFECT OF VACCINATION AND THE DEVELOPMENT OF HYBRID IMMUNITY Open
View article: Human T cells recognize HLA-DP–bound peptides in two orientations
Human T cells recognize HLA-DP–bound peptides in two orientations Open
Human leukocyte antigen (HLA) molecules present small peptide antigens to T cells, thereby allowing them to recognize pathogen-infected and cancer cells. A central dogma over the last 50+ y is that peptide binding to HLA molecules is media…
View article: SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells
SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells Open
Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4 + and CD8 + T cells in SARS-CoV-2-unexposed donors has been explained by the presence of T cells primed by other coronaviruses. However, based on the re…
View article: Sickle Cell Disease Patients Mount Adequate Humoral but Reduced Cellular Responses to COVID-19 Vaccination
Sickle Cell Disease Patients Mount Adequate Humoral but Reduced Cellular Responses to COVID-19 Vaccination Open
Introduction Sickle cell disease patients have an increased risk of severe and fatal coronavirus disease (COVID)-19 compared to the healthy population, even after immunization with the primary 2-dose COVID-19 mRNA vaccination schedule. We …
View article: <scp>SARS‐CoV</scp>‐2 <scp>mRNA</scp> vaccination of aplastic anemia patients is safe and effective
<span>SARS‐CoV</span>‐2 <span>mRNA</span> vaccination of aplastic anemia patients is safe and effective Open
Vaccines are an essential part of the fight against the COVID-19 pandemic. Especially immunocompromised patients at risk for a severe or fatal course of SARS-CoV-2 infection are expected to benefit from vaccination. While studies on SARS-C…
View article: Author response: SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells
Author response: SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells Open
View article: Increased <scp>CD8</scp> T‐cell immunity after <scp>COVID</scp>‐19 vaccination in lymphoid malignancy patients lacking adequate humoral response: An immune compensation mechanism?
Increased <span>CD8</span> T‐cell immunity after <span>COVID</span>‐19 vaccination in lymphoid malignancy patients lacking adequate humoral response: An immune compensation mechanism? Open
To the Editor: SARS-CoV-2 vaccine immunogenicity is commonly evaluated by measuring antibody titers against the SARS-CoV-2 Spike (S) protein. Previously, inferior humoral vaccination responses in patients with lymphoid malignancies have be…
View article: Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral Clearance
Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral Clearance Open
Virus-specific cellular and humoral responses are major determinants for protection from critical illness after SARS-CoV-2 infection. However, the magnitude of the contribution of each of the components to viral clearance remains unclear. …
View article: SARS-CoV-2-specific CD4 <sup>+</sup> and CD8 <sup>+</sup> T cell responses can originate from cross-reactive CMV-specific T cells
SARS-CoV-2-specific CD4 <sup>+</sup> and CD8 <sup>+</sup> T cell responses can originate from cross-reactive CMV-specific T cells Open
Detection of SARS-coronavirus-2 (SARS-CoV-2) specific CD4 + and CD8 + T cells in SARS-CoV-2-unexposed donors has been explained by the presence of T cells primed by other coronaviruses. However, based on the relative high frequency and pre…
View article: Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19 Open
View article: Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2 specific CD8 T cell responses following COVID-19
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2 specific CD8 T cell responses following COVID-19 Open
The immune system plays a major role in Coronavirus Disease 2019 (COVID-19) pathogenesis, viral clearance and protection against re-infection. Immune cell dynamics during COVID-19 have been extensively documented in peripheral blood, but r…
View article: Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?
Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity? Open
It is not exactly clear yet which type of immune response prevails to accomplish viral clearance in coronavirus disease 2019 (COVID-19). Studying a patient with chronic lymphocytic leukemia and hypogammaglobulinemia who suffered from COVID…
View article: Absence of rapid T cell control corresponds with delayed viral clearance in hospitalised COVID-19 patients
Absence of rapid T cell control corresponds with delayed viral clearance in hospitalised COVID-19 patients Open
SARS-CoV-2 viral load is associated with disease severity. A better understanding of immunological mechanisms involved in viral clearance is crucial to guide new therapeutic strategies. Here, we studied the timing of viral clearance in rel…
View article: Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2 specific CD8 T cell responses following COVID-19
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2 specific CD8 T cell responses following COVID-19 Open
The immune system plays a major role in Coronavirus Disease 2019 (COVID-19) pathogenesis, viral clearance and protection against re-infection. Immune cell dynamics during COVID-19 have been extensively documented in peripheral blood, but r…
View article: Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic
Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic Open