Cinta Moraleda
YOU?
Author Swipe
View article: Increase of Dengue in Pediatric Travelers in Madrid: A Multicentric Retrospective Experience
Increase of Dengue in Pediatric Travelers in Madrid: A Multicentric Retrospective Experience Open
Dengue fever has significantly increased globally, extending into non-endemic regions. This study aims to describe the epidemiological and clinical characteristics of pediatric dengue cases diagnosed in Madrid, Spain, over ten years. We co…
View article: Corrigendum: Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study
Corrigendum: Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study Open
[This corrects the article DOI: 10.3389/ijph.2025.1607246.].
View article: Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study
Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study Open
Objective To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study. Methods We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian …
View article: Persistent Symptoms (Lasting Longer than 1 Year) in Children Hospitalized with Acute COVID-19 Versus Other Conditions
Persistent Symptoms (Lasting Longer than 1 Year) in Children Hospitalized with Acute COVID-19 Versus Other Conditions Open
Background: We evaluated the prevalence and characteristics of persistent signs and/or symptoms in children and young people (CYP) one year after hospitalization for acute COVID-19 compared with a control group of CYP hospitalized for othe…
View article: Statistical Analysis Plan for the “Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia” clinical trial
Statistical Analysis Plan for the “Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia” clinical trial Open
Background The EMPIRICAL trial aims to assess safety and efficacy of an empirical treatment against cytomegalovirus (CMV) and tuberculosis (TB) compared to standard of care (SoC), on adverse events and 15-day and 1-year mortality among inf…
View article: Implications of mappings between International Classification of Diseases clinical diagnosis codes and Human Phenotype Ontology terms
Implications of mappings between International Classification of Diseases clinical diagnosis codes and Human Phenotype Ontology terms Open
Objective Integrating electronic health record (EHR) data with other resources is essential in rare disease research due to low disease prevalence. Such integration is dependent on the alignment of ontologies used for data annotation. The …
View article: Persistent symptoms after 1 year in hospitalized children with acute COVID-19 compared to other conditions
Persistent symptoms after 1 year in hospitalized children with acute COVID-19 compared to other conditions Open
Purpose We evaluated the prevalence and characteristics of persistent signs and/or symptoms in children and young people (CYP) one year after hospitalization for acute COVID-19 compared with a control group of CYP hospitalized for other co…
View article: Cancer is not a risk factor for severe COVID-19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantion recipients or comorbidities.
Cancer is not a risk factor for severe COVID-19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantion recipients or comorbidities. Open
The EPICO-SEHOP platform gathers data from children with SARS-CoV-2 in Spain, allowing comparison between children with cancer or allogeneic hematopoietic stem cell transplantation (alloHSCT) and those without. The infection is milder in t…
View article: PA-655 Severe pneumonia is associated with worse neurocognitive function among infants living with HIV
PA-655 Severe pneumonia is associated with worse neurocognitive function among infants living with HIV Open
Background Despite reduction of HIV-associated mortality in children with the implementation of antiretroviral treatment (ART), HIV-associated neurocognitive deficits are still of great concern. These are thought to result mainly from intr…
View article: OA-286 Plasma concentrations of first line antituberculosis drugs in infants with HIV and severe pneumonia: a pharmacokinetic sub-study of the empirical trial
OA-286 Plasma concentrations of first line antituberculosis drugs in infants with HIV and severe pneumonia: a pharmacokinetic sub-study of the empirical trial Open
Background Infants living with HIV are at high risk of tuberculosis and death. Optimal antituberculosis therapy is essential for favourable clinical outcomes particularly in severely ill children. Using WHO-recommended weight-band dosing, …
View article: OA-429 High mortality in African infants living with HIV hospitalized with severe pneumonia
OA-429 High mortality in African infants living with HIV hospitalized with severe pneumonia Open
Background Children with advanced HIV disease (AHD) are at an increased risk of morbidity and mortality. We describe mortality rates among infants with AHD hospitalized with severe pneumonia. Methods EMPIRICAL is an ongoing Phase II-III, o…
View article: PA-455 Bedside ultrasound for the diagnosis of tuberculosis in HIV-positive infants hospitalized with severe pneumonia
PA-455 Bedside ultrasound for the diagnosis of tuberculosis in HIV-positive infants hospitalized with severe pneumonia Open
Background Tuberculosis (TB) diagnosis is challenging in children, particularly in infants, contributing to high TB-related mortality. Up to 30% of infants with pulmonary TB have concurrent extrapulmonary disease, with findings that can fr…
View article: PA-477 Building a national network for inpatient pediatric clinical research in Mozambique
PA-477 Building a national network for inpatient pediatric clinical research in Mozambique Open
Background Universidade Eduardo Mondlane (UEM) and Hospital Central de Maputo (HCM) were invited to join a consortium of established pediatric research groups from 5 other sub-Saharan Africa countries in a proposal for the EMPIRICAL trial,…
View article: PA-450 Laboratory diagnosis of Pneumocystis jirovecii in HIV-positive infants with severe pneumonia using non-invasive samples
PA-450 Laboratory diagnosis of Pneumocystis jirovecii in HIV-positive infants with severe pneumonia using non-invasive samples Open
Background The laboratory diagnosis of P. jirovecii pneumonia (PCP) is typically based on microscopic observation of cysts and trophic forms on deep respiratory specimens. In low-income countries, access to bronchoalveolar lavage is limite…
View article: Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial
Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial Open
Background We evaluated dolutegravir pharmacokinetics in infants with human immunodeficiency virus (HIV) receiving dolutegravir twice daily (BID) with rifampicin-based tuberculosis (TB) treatment compared with once daily (OD) without rifam…
View article: First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia
First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia Open
Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference val…
View article: PHENOTYPIC VARIATION IN DISEASE SEVERITY AMONG HOSPITALIZED PEDIATRIC PATIENTS WITH COVID-19: ASSESSING THE IMPACT OF COVID-19 IN THE EPICO STUDY
PHENOTYPIC VARIATION IN DISEASE SEVERITY AMONG HOSPITALIZED PEDIATRIC PATIENTS WITH COVID-19: ASSESSING THE IMPACT OF COVID-19 IN THE EPICO STUDY Open
Background: SARS-CoV-2 infection has been extensively documented since the onset of the pandemic, particularly in the adult population. However, there is a lack of evidence describing the phenotypic manifestations of the disease in the ped…
View article: WHAT TO LOOK FOR IN CHEST X-RAYS OF PEDIATRIC PATIENTS WITH COVID-19: INSIGHTS FROM A COLOMBIAN COHORT.
WHAT TO LOOK FOR IN CHEST X-RAYS OF PEDIATRIC PATIENTS WITH COVID-19: INSIGHTS FROM A COLOMBIAN COHORT. Open
Background: Despite advancements in vaccination and the transition from pandemic to endemic, SARS-CoV-2 continues to pose a medical challenge, particularly among children. In this context, imaging diagnostics, such as chest x-rays, are cru…
View article: Clinical outcomes and antibody transfer in a cohort of infants born to mothers with SARS-COV-2 infection during pregnancy (Coronascope Study)
Clinical outcomes and antibody transfer in a cohort of infants born to mothers with SARS-COV-2 infection during pregnancy (Coronascope Study) Open
Purpose: We aimed to describe the outcomes, focusing on the hearing and neurological development, of children born to mothers with SARS-CoV-2 infection during pregnancy, and to evaluate the persistence of maternal antibodies in the first m…
View article: Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change
Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change Open
Background: Although super-boosted lopinavir/ritonavir (LPV/r; ratio 4:4 instead of 4:1) is recommended for infants living with HIV and receiving concomitant rifampicin, in clinical practice, many different LPV/r dosing strategies are appl…
View article: Treatments for multi-system inflammatory syndrome in children — discharge, fever, and second-line therapies
Treatments for multi-system inflammatory syndrome in children — discharge, fever, and second-line therapies Open
Scarce evidence exists about the best treatment for multi-system inflammatory syndrome (MIS-C). We analyzed the effects of steroids, intravenous immunoglobulin (IVIG), and their combination on the probability of discharge over time, the pr…
View article: Safety and Acceptance of COVID-19 Vaccination After Multisystem Inflammatory Syndrome in Children (MIS-C) in Spain
Safety and Acceptance of COVID-19 Vaccination After Multisystem Inflammatory Syndrome in Children (MIS-C) in Spain Open
In this cohort of 42 adolescents with a previous multisystem inflammatory syndrome (MIS-C) diagnosis, 32 (76.2%) were vaccinated with COVID-19 vaccines, with a low incidence of relevant adverse events. More importantly, no new MIS-C or myo…
View article: Comparison of pneumonia features in children caused by SARS‐CoV‐2 and other viral respiratory pathogens
Comparison of pneumonia features in children caused by SARS‐CoV‐2 and other viral respiratory pathogens Open
Background Pneumonia is a frequent manifestation of coronavirus disease 2019 (COVID‐19) in hospitalized children. Methods The study involved 80 hospitals in the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Spanish Pediatric…
View article: Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial
Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial Open
Background Pneumonia is the primary cause of death among HIV-infected children in Africa, with mortality rates as high as 35–40% in infants hospitalized with severe pneumonia. Bacterial pathogens and Pneumocystis jirovecii are well known c…