Explanipedia

Drivers of Pancreatic Cancer: Beyond the Big 4 Open

Laura Porcza, Rafael Ballesteros-Cillero, Lok To Lam, Ciro Maiello, Nicholas R. Leslie · 2025

Background: Pancreatic cancer is frequently identified as the cancer type with the shortest probable survival time after diagnosis, and efforts to develop successful treatments have had a very limited impact in the clinic. One reason for t…

DNA hypermethylation of MED1 and MED23 as early diagnostic biomarkers for unsolved issues in atrial fibrillation Open

Concetta Schiano, Teresa Infante, Giuditta Benincasa, Jacopo Burrello, Antonio Ruocco , et al. · 2025

For the first time, we showed that DNA methylation changes are associated with regulation of MED complex subunits in early diagnosis of AF patients. Clinically, MED1 and MED23 hypermethylation showed a diagnostic value not inferior to circ…

MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation Open

Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco , et al. · 2024

Aims Advanced heart failure (AHF) is characterized by recurrent episodes of haemodynamic instability and frequent hospitalizations, leading to a progressive decline in quality of life and high mortality rates. The objectives of this study …

Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification Open

Monica Franzese, Mario Zanfardino, Andrea Soricelli, Annapaola Coppola, Ciro Maiello , et al. · 2024

Familial dilated cardiomyopathy (DCM) is among the leading indications for heart transplantation. DCM alters the transcriptomic profile. The alteration or activation/silencing of physiologically operating transcripts may explain the onset …

Role of HLA matching and donor specific antibody development in long-term survival, acute rejection and cardiac allograft vasculopathy Open

Dario Costa, Antonietta Picascia, Vincenzo Grimaldi, Cristiano Amarelli, Andrea Petraio , et al. · 2024

Although there are different data supporting benefits of HLA matching in kidney transplantation, its role in heart transplantation is still unclear. HLA mismatch (MM) between donor and recipient can lead to the development of donor-specifi…

Artificial intelligence, big data and heart transplantation: Actualities Open

Vittorio Palmieri, Andrea Montisci, Maria Teresa Vietri, P.C. Colombo, Sílvia Carbonell Sala , et al. · 2023

P476 TOLERATED SUSTAINED VENTRICULAR FIBRILLATION IN LVAD RECIPIENT: THE WALKING DEAD Open

Alessandro Mauriello, Anna Chiara Maratea, Cristiano Amarelli, Ciro Maiello, Francesco S. Loffredo , et al. · 2023

A 73–year–old man comes to the cardiac surgery clinic, due to the onset of an arrhythmic storm. In 1999, the patient was diagnosed with dilated cardiomyopathy with finding of a pathogenic mutation of the MYH7 gene by NGS panel analysis. Be…

Novel insights in the clinical management of hyperimmune patients before and after transplantation Open

Vincenzo Grimaldi, Martina Pagano, Giusi Moccia, Ciro Maiello, Paride De Rosa , et al. · 2023

Big Data in cardiac surgery: real world and perspectives Open

Andrea Montisci, Vittorio Palmieri, Maria Teresa Vietri, Sílvia Carbonell Sala, Ciro Maiello , et al. · 2022

Big Data, and the derived analysis techniques, such as artificial intelligence and machine learning, have been considered a revolution in the modern practice of medicine. Big Data comes from multiple sources, encompassing electronic health…

Incidence, Risk Factors and Clinical Implications of Glucose Metabolic Changes after Heart Transplant Open

Emanuele Durante‐Mangoni, Domenico Iossa, Valeria Iorio, Irene Mattucci, U. Malgeri , et al. · 2022

Diabetes mellitus (DM) arising de novo after transplant is a common complication, sharing many features with type 2 DM but also specific causes, such as administration of steroids and immunosuppressive drugs. Although post-transplant DM (P…

Sodium-glucose cotransporter-2 (SGLT2) expression in diabetic and non-diabetic failing human cardiomyocytes Open

Raffaele Marfella, Lucia Scisciola, Nunzia D’Onofrio, Ciro Maiello, Maria Consiglia Trotta , et al. · 2022

This study aimed at investigating the SGLT2 expression in human cardiomyocytes. Human studies evaluating cardiomyocyte SGLT2s expression are limited. To better clarify this issue, SGLT2 protein expression was assessed in human hearts of di…

Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts Open

Raffaele Marfella, Nunzia D’Onofrio, Gelsomina Mansueto, Vincenzo Grimaldi, Maria Consiglia Trotta , et al. · 2022

Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry Open

Andrea Salzano, Roberta D’Assante, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo , et al. · 2022

Human Cardiac Progenitor Cell-Derived Extracellular Vesicles Exhibit Promising Potential for Supporting Cardiac Repair in Vitro Open

Veronica Romano, Immacolata Belviso, Anna Maria Sacco, Domenico Cozzolino, Daria Nurzyńska , et al. · 2022

Although human Cardiac Progenitor Cells (hCPCs) are not retained by host myocardium they still improve cardiac function when injected into ischemic heart. Emerging evidence supports the hypothesis that hCPC beneficial effects are induced b…

Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry Open

Alfredo De Giorgi, Alberto M. Marra, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo , et al. · 2022

Introduction Data from the “Trattamento Ormonale nello Scompenso CArdiaco” (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent c…

Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry Open

Andrea Salzano, Roberta D’Assante, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo , et al. · 2022

Background Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance- IR or diabetes mellitus- T2D) display increased morbidi…

Sodium-Glucose Cotransporter-2 (SGLT2) Expression in Diabetic and Non-Diabetic Failing Human Cardiomyocytes Open

Raffale Marfella, Lucia Scisciola, Nunzia D’ Onofrio, Ciro Maiello, Maria Consiglia Trotta , et al. · 2022

Sodium-Glucose Cotransporter-2 (SGLT2) Expression in Diabetic and Non-Diabetic Failing Human Cardiomyocytes Open

Raffale Marfella, Nunzia D’ Onofrio, Lucia Scisciola, Ciro Maiello, Maria Consiglia Trotta , et al. · 2022

Machine Learning and Bioinformatics Framework Integration to Potential Familial DCM-Related Markers Discovery Open

Concetta Schiano, Monica Franzese, Filippo Geraci, Mario Zanfardino, Ciro Maiello , et al. · 2021

Objectives: Dilated cardiomyopathy (DCM) is characterized by a specific transcriptome. Since the DCM molecular network is largely unknown, the aim was to identify specific disease-related molecular targets combining an original machine lea…

Sodium/glucose cotransporter 2 (SGLT2) inhibitors improve cardiac function by reducing JunD expression in human diabetic hearts Open

Raffaele Marfella, Nunzia D’Onofrio, Maria Consiglia Trotta, Celestino Sardu, Lucia Scisciola , et al. · 2021

Early pathogenesis in human diabetic cardiomyopathy is associated with JunD/PPAR-γ overexpression and lipid accumulation following HTX in recipients with diabetes. Remarkably, this phenomenon was reduced by concomitant therapy with SGLT2i,…

Veno-arterial Extracorporeal Membrane Oxygenation as Bridge to Heart Transplantation: The Way Forward Open

Andrea Montisci, Francesco Donatelli, Silvia Cirri, Enrico Coscioni, Ciro Maiello , et al. · 2021

Advanced heart failure (HF) represents a public health priority due to the increase of affected patients and the meaningful mortality. Durable mechanical circulatory support (MCS) and heart transplantation (HTx) are unique therapies for en…

Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte Open

Nunzia D’Onofrio, Lucia Scisciola, Celestino Sardu, Maria Consiglia Trotta, Marisa De Feo , et al. · 2021

Epigenetic Therapies for Heart Failure: Current Insights and Future Potential Open

Claudio Napoli, Paola Bontempo, Vittorio Palmieri, Enrico Coscioni, Ciro Maiello , et al. · 2021

Despite the current reductionist approach providing an optimal indication for diagnosis and treatment of patients with heart failure with reduced ejection fraction (HFrEF), there are no standard pharmacological therapies for heart failure …

Effect of immunosuppression maintenance in solid organ transplant recipients with COVID‐19: Systematic review and meta‐analysis Open

Arta Karruli, Serenella Spiezia, Filomena Boccia, Massimo Gagliardi, Fabian Patauner , et al. · 2021

Background The aim of this study was to assess the effect of continuing immune suppressive therapy in solid organ transplant recipients (SOTR) with coronavirus disease 2019 (COVID‐19). Methods Systematic review and meta‐analysis of data on…

Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the T.O.S.CA. Registry Open

Antonio Cittadini, Andrea Salzano, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo , et al. · 2021

Aims Recent evidence supports the occurrence of multiple hormonal and metabolic deficiency syndrome (MHDS) in chronic heart failure (CHF). However, no large observational study has unequivocally demonstrated its impact on CHF progression a…

Additional file 3 of Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte Open

Nunzia D’Onofrio, Lucia Scisciola, Celestino Sardu, Maria Consiglia Trotta, Marisa De Feo , et al. · 2021

Additional file 3: Figure S3. Mass spectra of the triply charged hACE2 tryptic peptide 466-475 in the glycated (panel A) and non-glycated (panel B) form. hACE2 is for human Angiotensin Converting enzyme 2 type.

Additional file 4 of Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte Open

Nunzia D’Onofrio, Lucia Scisciola, Celestino Sardu, Maria Consiglia Trotta, Marisa De Feo , et al. · 2021

Additional file 4: Figure S4. Mass spectra of the triply charged hACE2 tryptic peptide 560-577 in the glycated (panel A) and non-glycated (panel B) form. hACE2 is for human Angiotensin Converting enzyme 2 type.

The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive Cells Open

Immacolata Belviso, Francesco Angelini, Franca Di Meglio, Vittorio Picchio, Anna Maria Sacco , et al. · 2020

Cardiac adverse remodeling is characterized by biological changes that affect the composition and architecture of the extracellular matrix (ECM). The consequently disrupted signaling can interfere with the balance between cardiogenic and p…

Adult cardiovascular surgery and the coronavirus disease 2019 (COVID-19) pandemic: the Italian experience Open

Francesco Donatelli, Antonio Miceli, Mattia Glauber, Silvia Cirri, Ciro Maiello , et al. · 2020

The coronavirus disease 2019 (COVID-19) pandemic has profoundly affected all health care professionals. The outbreak required a thorough reorganization of the Italian regional local health care system to preserve resources such as ventilat…

In Situ Immune Profiling Identifies Immune Players Involved in Allograft Rejection Open

Claudio Napoli, Francesco Donatelli, Ciro Maiello · 2020

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