Explanipedia

Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma Open

Cissy Yong, Christina Schmidt, Ming Yang, Alex von Kriegsheim, Anne Y. Warren , et al. · 2025

Human isotopic tracer studies are key for in vivo studies of cancer metabolism. Yet, the effects of sampling conditions on the tissue metabolome remain understudied. Here, we perform a 13 C-glucose study coupled with metabolomic, transcrip…

Factors Affecting University Students’ Happiness Over Two Years at Universiti Malaysia Sabah: A Retrospective Observational Study Open

Nicholas Tze Ping Pang, Vie Cheong Thong, Cissy Yong, Assis Kamu, Chong Mun Ho · 2025

Introduction Happiness is a key component of subjective well-being, influencing health, academic performance, and life satisfaction. Research on university students’ happiness in East Malaysia remains limited, despite the influence of soci…

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities Open

Jianfeng Ge, Shoko Hirosue, Saroor A. Patel, Ludovic Wesolowski, Anna Dyas , et al. · 2025

SUMMARY The von Hippel-Lindau tumor suppressor (VHL) is a component of a ubiquitin ligase complex that normally controls cellular responses to hypoxia. Endogenous VHL is also utilized by proteolysis-targeting chimera (PROTAC) protein degra…

Clinical outcomes of early and delayed cholecystectomy for acute gallstone-related disease Open

Mathew Vithayathil, Cissy Yong, Khaled Dawas · 2025

DLC is associated with significant recurrence of gallstone-related complications. Re-admission to hospital incurs additional inpatient stay, and investigation, leading to a negative impact on patients' health and additional financial burde…

Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma Open

Christian Frezza, Cissy Yong, Christina Schmidt, Ming Yang, Alex von Kriegsheim , et al. · 2024

Human isotopic tracer studies are fast becoming the gold standard model to study cancer metabolism in vivo . Analysed tissues are typically retrieved after surgical resection, which exposes them to a variable extent of warm ischaemia. Alth…

Probing intratumoral metabolic compartmentalisation in fumarate hydratase-deficient renal cancer using clinical hyperpolarised13C-MRI and mass spectrometry imaging Open

Ines Horvat‐Menih, Ruth Casey, James Denholm, Grégory Hamm, Heather Hulme , et al. · 2024

Background Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant…

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma Open

Akash Kaushik, Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang , et al. · 2022

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL …

Human Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor Open

Marianne Perera, Edward JD Greenwood, Thomas W. M. Crozier, Elizabeth Elder, Janika Schmitt , et al. · 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused widespread morbidity and mortality since its onset in late 2019. Here, we demonstrate that prior infection…

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma Open

Akash Kaushik, Lindsey K. Burroughs, Amy Tarangelo, Mukundan Ragavan, Cheng‐Yang Wu , et al. · 2022

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed metabolism in patient-derived xenografts (tumorgrafts) from diverse forms of RCC. Tumorgrafts from VHL -mutant…

HIRA loss transforms FH -deficient cells Open

Lorea Valcárcel-Jiménez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang , et al. · 2022

Fumarate hydratase (FH) is a mitochondrial enzyme that catalyzes the reversible hydration of fumarate to malate in the tricarboxylic acid (TCA) cycle. Germline mutations of FH lead to hereditary leiomyomatosis and renal cell carcinoma (HLR…

The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer Open

Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K. Richardson , et al. · 2022

Large-scale human genetic data 1–3 have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, w…

HIRA loss transforms FH-deficient cells Open

Lorea Valcárcel-Jiménez, Connor Rogerson, Cissy Yong, Christina Schmidt, Ming Yang , et al. · 2022

Fumarate Hydratase (FH) is a mitochondrial enzyme that catalyses the reversible hydration of fumarate to malate in the TCA cycle. Germline mutations of FH lead to HLRCC, a cancer syndrome characterised by a highly aggressive form of renal …

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 Open

Dami A. Collier, Isabella A.T.M. Ferreira, Prasanti Kotagiri, Rawlings Datir, Eleanor Y. Lim , et al. · 2021

Re: Transcriptomic Signatures Related to the Obesity Paradox in Patients with Clear Cell Renal Cell Carcinoma: A Cohort Study. Open

Cissy Yong, Grant S. Stewart · 2020

Immunohistochemistry as a tool for screening rare renal cancers Open

Cissy Yong, Grant D. Stewart, Christian Frezza · 2019

Recent additions of succinate dehydrogenase (SDH) and (Hereditary Leiomyomatosis and Renal Cell Cancer, HLRCC, associated) fumarate hydratase (FH)-deficient renal cell carcinomas (RCC) to the 2016 WHO Classification of Renal Tumours (1) ha…

Toll-like receptors 2 and 6 mediate apoptosis and inflammation in ischemic skeletal myotubes Open

Hemanshu Patel, Cissy Yong, Ali Navi, Sidney Shaw, Shiwen Xu , et al. · 2019

Critical limb ischemia (CLI) is associated with skeletal muscle damage. However, the pathophysiology of the muscle damage is poorly understood. Toll-like receptors (TLR) have been attributed to play a role in ischemia-induced tissue damage…

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