Clair Rose
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View article: The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake
The β-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake Open
Background Insecticide resistance in disease-transmitting arthropods of agricultural, veterinary, and public health significance poses a significant threat to vector control programs worldwide. Previous studies demonstrated that blood-feed…
View article: The beta-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake
The beta-triketone, nitisinone, kills insecticide-resistant mosquitoes through cuticular uptake Open
The efficacy of numerous vector control initiatives is compromised by growing insecticide resistance among disease-transmitting arthropods of agricultural, veterinary, and public health significance. Previous investigations on hematophagou…
View article: The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector
The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector Open
Trypanosoma brucei spp. develop into mammalian-infectious metacyclic trypomastigotes inside tsetse salivary glands. Besides acquiring a variant surface glycoprotein (VSG) coat, little is known about the metacyclic expression of invariant s…
View article: A Composite Recombinant Salivary Proteins Biomarker for <i>Phlebotomus argentipes</i> Provides a Surveillance Tool Postelimination of Visceral Leishmaniasis in India
A Composite Recombinant Salivary Proteins Biomarker for <i>Phlebotomus argentipes</i> Provides a Surveillance Tool Postelimination of Visceral Leishmaniasis in India Open
Incidence of visceral leishmaniasis (VL) in the Indian subcontinent (ISC) has declined by more than 95% since initiation of the elimination program in 2005. As the ISC transitions to the postelimination surveillance phase, an accurate meas…
View article: Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes
Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes Open
African sleeping sickness is caused by Trypanosoma brucei , a parasite transmitted by the bite of a tsetse fly. Trypanosome infection induces a severe transcriptional downregulation of tsetse genes encoding for salivary proteins, which red…
View article: Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis Open
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic in…
View article: Tsetse salivary glycoproteins are modified with paucimannosidic<i>N</i>-glycans, are recognised by C-type lectins and bind to trypanosomes
Tsetse salivary glycoproteins are modified with paucimannosidic<i>N</i>-glycans, are recognised by C-type lectins and bind to trypanosomes Open
African sleeping sickness is caused by Trypanosoma brucei, a parasite transmitted by the bite of a tsetse fly. Trypanosome infection induces a severe transcriptional downregulation of tsetse genes encoding for salivary proteins, which redu…
View article: Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis Open
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic in…
View article: Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations a…
View article: Characterization of a novel glycosylated glutathione transferase of <i>Onchocerca ochengi</i>, closest relative of the human river blindness parasite
Characterization of a novel glycosylated glutathione transferase of <i>Onchocerca ochengi</i>, closest relative of the human river blindness parasite Open
Filarial nematodes possess glutathione transferases (GSTs), ubiquitous enzymes with the potential to detoxify xenobiotic and endogenous substrates, and modulate the host immune system, which may aid worm infection establishment, maintenanc…
View article: The Glossina Genome Cluster: Comparative Genomic Analysis of the Vectors of African Trypanosomes
The Glossina Genome Cluster: Comparative Genomic Analysis of the Vectors of African Trypanosomes Open
Background: Tsetse flies (Glossina sp.) are the sole vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live…
View article: <i>Trypanosoma brucei</i>colonises the tsetse gut via an immature peritrophic matrix in the proventriculus
<i>Trypanosoma brucei</i>colonises the tsetse gut via an immature peritrophic matrix in the proventriculus Open
The peritrophic matrix (PM) of haematophagus insects is a chitinous structure that surrounds the bloodmeal, forming a protective barrier against oral pathogens and abrasive particles. To establish an infection in the tsetse midgut, Trypano…
View article: Additional file 4: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 4: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Orthology group species composition data. (XLSX 3807 kb)
View article: Additional file 7: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 7: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Results of a CAFĂ analysis of the variable orthology groups to identify their closest dipteran homologs. (XLSX 224 kb)
View article: Additional file 8: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 8: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Summary of the BLAST results of all members of the variable orthology groups to identify their closest dipteran homologs. (XLSX 679 kb)
View article: Additional file 11: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 11: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
List of putative cuticle protein genes identified in all Glossina species. (XLSX 51 kb)
View article: Additional file 10: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 10: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
List of gene IDs and full names for Drosophila immunity-associated genes and the orthologous/paralogous genes identified in Musca and the Glossina species. (XLSX 122 kb)
View article: Additional file 9: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 9: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Counts of Glossina and Musca orthologs/paralogs of Drosophila melanogaster immunity-associated genes. (XLSX 37 kb)
View article: Additional file 5: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 5: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Top GO results of genus- and sub-genus-specific gene ID. (XLSX 21 kb)
View article: Additional file 3: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 3: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Raw ensemble dipteran orthology data. (TXT 1842 kb)
View article: Additional file 6: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 6: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Results from the BLAST analysis of Glossina-specific serine proteases. (XLSX 22 kb)
View article: Additional file 12: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Additional file 12: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Transcription Factor Data. (ZIP 883 kb)
View article: The crystal structure and localization of<i>Trypanosoma brucei</i>invariant surface glycoproteins suggest a more permissive VSG coat in the tsetse-transmitted metacyclic stage
The crystal structure and localization of<i>Trypanosoma brucei</i>invariant surface glycoproteins suggest a more permissive VSG coat in the tsetse-transmitted metacyclic stage Open
Trypanosoma brucei spp. develop into mammalian-infectious metacyclic trypomastigotes inside the tsetse salivary glands. Besides acquiring a variant surface glycoprotein (VSG) coat, nothing is known about expression of invariant surface ant…
View article: Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans
Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans Open
Tsetse flies are the principal insect vectors of African trypanosomes—sleeping sickness in humans and Nagana in cattle. One of the tsetse fly species, Glossina morsitans morsitans, is host to the parasite, Trypanosoma brucei, a major cause…
View article: Unzipping the barriers: Determining the role of the peritrophic matrix in Trypanosoma brucei migration through the midgut of Glossina morsitans morsitans
Unzipping the barriers: Determining the role of the peritrophic matrix in Trypanosoma brucei migration through the midgut of Glossina morsitans morsitans Open
Tsetse flies serve as biological vectors for several species of African trypanosomes. These parasites undergo a life-cycle stage in both mammals and in the insect. Within the fly, it is proposed that for successful survival, proliferation …