Claire A. McClain
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View article: Nanotechnologies for Physiology-Informed Drug Delivery to the Lymphatic System
Nanotechnologies for Physiology-Informed Drug Delivery to the Lymphatic System Open
Accompanying the increasing translational impact of immunotherapeutic strategies to treat and prevent disease has been a broadening interest across both bioscience and bioengineering in the lymphatic system. Herein, the lymphatic system ph…
View article: Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets
Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets Open
Understanding the immune response to hydrogel implantation is critical for the design of immunomodulatory biomaterials. To study the progression of inflammation around poly(ethylene glycol) hydrogels presenting Arg-Gly-Asp (RGD) peptides a…
View article: Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons
Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons Open
DNA repair within neurons Humans have only a limited capacity to generate new neurons. These cells thus need to repair errors in the genome. To better understand this process, Reid et al. developed Repair-seq, a method to locate DNA repair…
View article: Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival
Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival Open
Local biomaterial-mediated delivery of PD-L1 induces alloislet graft survival and function in a murine model of type 1 diabetes.
View article: Abstract 107: SPADE Analysis Reveals The Recruitment Of Rare Immune Cell Subtypes To Site Of Injury Following Treatment With Immunomodulatory Hydrogels
Abstract 107: SPADE Analysis Reveals The Recruitment Of Rare Immune Cell Subtypes To Site Of Injury Following Treatment With Immunomodulatory Hydrogels Open
Purpose - Wound care following surgical procedures involves careful management, reducing risk of infection, and maximizing tissue oxygenation. Even with new strides in biological and synthetic products, achieving adequate wound care remain…
View article: Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons
Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons Open
Neurons are the longest-living cells in our bodies, becoming post-mitotic in early development upon terminal differentiation. Their lack of DNA replication makes them reliant on DNA repair mechanisms to maintain genome fidelity. These repa…