Claire C. Sharpe
YOU?
Author Swipe
View article: Acute Supplementation With Green Coffee Extract and α-Lipoic Acid Enhances Postprandial Insulin Sensitivity in Healthy Females
Acute Supplementation With Green Coffee Extract and α-Lipoic Acid Enhances Postprandial Insulin Sensitivity in Healthy Females Open
View article: Applying an after-action review process to examine a complex public health response in New South Wales (NSW), Australia: lessons for reflective practice
Applying an after-action review process to examine a complex public health response in New South Wales (NSW), Australia: lessons for reflective practice Open
Objective After-action reviews (AARs) are used to systematically examine the functions, capabilities and barriers impacting effective pandemic responses. This paper describes the methods used for and the lessons learnt from undertaking the…
View article: Prophylaxis for renal patients at risk of COVID-19 infection: results from the intranasal niclosamide randomised, double blinded, placebo controlled arm of the PROTECT-V platform trial
Prophylaxis for renal patients at risk of COVID-19 infection: results from the intranasal niclosamide randomised, double blinded, placebo controlled arm of the PROTECT-V platform trial Open
View article: Impact of hyperkalaemia on renin–angiotensin–aldosterone (RAAS) inhibitor reduction or withdrawal following hospitalisation
Impact of hyperkalaemia on renin–angiotensin–aldosterone (RAAS) inhibitor reduction or withdrawal following hospitalisation Open
Background Inhibitors of the renin–angiotensin–aldosterone system (RAAS), such as ACE inhibitors (ACEi), angiotensin-II receptor blockers and mineralocorticoid receptor antagonists, reduce morbidity and mortality in hypertension, congestiv…
View article: Epigenetic associations with kidney disease in individuals of African ancestry with <i>APOL1</i> high-risk genotypes and HIV
Epigenetic associations with kidney disease in individuals of African ancestry with <i>APOL1</i> high-risk genotypes and HIV Open
Background Apolipoprotein L1 (APOL1) high-risk variants are major determinants of chronic kidney disease (CKD) in people of African ancestry. Previous studies have identified epigenetic changes in relation to kidney function and CKD, but n…
View article: Estimation of Health State Utility Values for Immunoglobulin A Nephropathy: A Time Trade-Off Analysis
Estimation of Health State Utility Values for Immunoglobulin A Nephropathy: A Time Trade-Off Analysis Open
Our results indicated that various IgAN health states are associated with impaired health status, with substantial utility decrements related to disease progression, elevated proteinuria, and nephrotic syndrome.
View article: The burden of hyperkalaemia on hospital healthcare resources
The burden of hyperkalaemia on hospital healthcare resources Open
View article: Ensuring fairness in assessment in health professions education: rapid analysis tools to detect differential item functioning across groups
Ensuring fairness in assessment in health professions education: rapid analysis tools to detect differential item functioning across groups Open
View article: Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study
Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study Open
Background Estimation of glomerular filtration rate using equations based on creatinine is widely used to manage chronic kidney disease. In the UK, the Chronic Kidney Disease Epidemiology Collaboration creatinine equation is recommended. O…
View article: Achieving Benchmarks for National Quality Indicators Reduces Recurrence and Progression in Non–muscle-invasive Bladder Cancer
Achieving Benchmarks for National Quality Indicators Reduces Recurrence and Progression in Non–muscle-invasive Bladder Cancer Open
Following the first 3 yr of implementing a novel quality performance indicator programme in Scotland, we evaluated compliance and outcomes in non-muscle-invasive bladder cancer. In 2688 patients followed up for 5 yr, we found that achievin…
View article: The burden of hyperkalaemia on hospital healthcare resources
The burden of hyperkalaemia on hospital healthcare resources Open
View article: Understanding SARS-CoV-2 Delta and Omicron variant transmission and vaccine impact in schools and child-care settings in Australia: a population-based study
Understanding SARS-CoV-2 Delta and Omicron variant transmission and vaccine impact in schools and child-care settings in Australia: a population-based study Open
NSW Government Department of Health.
View article: Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function
Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function Open
This study did not find any clinically significant change in serum markers of renal function in the one month after intravitreal ranibizumab or aflibercept. It did, however, find a non-significant rise in creatinine with aflibercept, that …
View article: An Overview of Solid Organ Transplantation in Patients With Sickle Cell Disease
An Overview of Solid Organ Transplantation in Patients With Sickle Cell Disease Open
Sickle cell disease is a common genetic disorder affecting >300 000 people across the world. The vast majority of patients cared for in high-resource settings live well into adulthood, but many develop a high burden of disease complication…
View article: Outcome and effect of vaccination in SARS-CoV-2 Omicron infection in hemodialysis patients: a cohort study
Outcome and effect of vaccination in SARS-CoV-2 Omicron infection in hemodialysis patients: a cohort study Open
Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity of infection. Little information is available on disease severity and vaccine efficacy since…
View article: Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1
Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1 Open
View article: Severity of COVID-19 after Vaccination among Hemodialysis Patients
Severity of COVID-19 after Vaccination among Hemodialysis Patients Open
Background and objectives Patients receiving hemodialysis are at high risk from coronavirus disease 2019 (COVID-19) and demonstrate impaired immune responses to vaccines. There have been several descriptions of their immunologic responses …
View article: Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV
Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV Open
Our results extend previously reported associations between SCT and kidney disease to people with HIV. In people of African ancestry with HIV, these associations were largely restricted to those with APOL1 low-risk genotypes.
View article: Correction to: COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort
Correction to: COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort Open
View article: COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort
COVID-19-related acute kidney injury; incidence, risk factors and outcomes in a large UK cohort Open
View article: Point of care testing using rapid automated antigen testing for SARS-COV-2 in care homes – an exploratory safety, usability and diagnostic agreement evaluation
Point of care testing using rapid automated antigen testing for SARS-COV-2 in care homes – an exploratory safety, usability and diagnostic agreement evaluation Open
Introduction Successful adoption of POCTs (Point-of-Care tests) for COVID-19 in care homes requires the identification of ideal use cases and a full understanding of the contextual and usability factors that affect test results and minimis…
View article: Stimulated Phosphorylation of ERK in Mouse Kidney Mesangial Cells is Dependent Upon Expression of Cav3.1
Stimulated Phosphorylation of ERK in Mouse Kidney Mesangial Cells is Dependent Upon Expression of Cav3.1 Open
Background: T-type calcium channels (TTCC) are low voltage activated channels that are widely expressed in the heart, smooth muscle and neurons. They are known to impact on cell cycle progression in cancer and smooth muscle cells and more …
View article: Estimated glomerular filtration rate equations in people of self-reported black ethnicity in the United Kingdom: Inappropriate adjustment for ethnicity may lead to reduced access to care
Estimated glomerular filtration rate equations in people of self-reported black ethnicity in the United Kingdom: Inappropriate adjustment for ethnicity may lead to reduced access to care Open
Assessment in African populations suggest adjustment for ethnicity in estimated glomerular filtration rate (eGFR) equations derived from African Americans lead to overestimation of GFR and failure to determine severity in chronic kidney di…
View article: Risk of COVID-19 Disease, Dialysis Unit Attributes, and Infection Control Strategy among London In-Center Hemodialysis Patients
Risk of COVID-19 Disease, Dialysis Unit Attributes, and Infection Control Strategy among London In-Center Hemodialysis Patients Open
Background and objectives Patients receiving in-center hemodialysis treatment face unique challenges during the coronavirus disease 2019 (COVID-19) pandemic, specifically the need to attend for treatment that prevents self-isolation. Dialy…
View article: COVID-19-related acute kidney injury; temporal changes in incidence rate and outcomes in a large UK cohort
COVID-19-related acute kidney injury; temporal changes in incidence rate and outcomes in a large UK cohort Open
Background : Acute kidney injury (AKI) is common among patients hospitalised with COVID-19, and associated with worse prognosis. The aim of this study was to investigate the epidemiology, risk factors and outcomes of AKI in patients with C…
View article: Point of Care Testing using rapid automated Antigen Testing for SARS-COV-2 in Care Homes – an exploratory safety, usability and diagnostic agreement evaluation
Point of Care Testing using rapid automated Antigen Testing for SARS-COV-2 in Care Homes – an exploratory safety, usability and diagnostic agreement evaluation Open
Introduction Successful adoption of POCTs (Point-of-Care tests) for COVID-19 in care homes requires the identification of ideal use cases and a full understanding of contextual and usability factors that affect test results and minimise bi…
View article: Is point-of-care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a point-of-care polymerase chain reaction test for SARS-CoV-2
Is point-of-care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a point-of-care polymerase chain reaction test for SARS-CoV-2 Open
Introduction Reliable rapid testing for COVID-19 is needed in care homes to reduce the risk of outbreaks and enable timely care. This study aimed to examine the usability and test performance of a point of care polymerase chain reaction (P…
View article: POS-513 RISK OF COVID-19 DISEASE, DIALYSIS UNIT ATTRIBUTES AND INFECTION CONTROL STRATEGY AMONG LONDON IN-CENTRE HAEMODIALYSIS PATIENTS: A RETROSPECTIVE COHORT STUDY
POS-513 RISK OF COVID-19 DISEASE, DIALYSIS UNIT ATTRIBUTES AND INFECTION CONTROL STRATEGY AMONG LONDON IN-CENTRE HAEMODIALYSIS PATIENTS: A RETROSPECTIVE COHORT STUDY Open
View article: POS-225 ESTIMATED GLOMERULAR FILTRATION RATE EQUATIONS: DO WE NEED TO USE THE ETHNICITY CORRECTION FACTOR IN PEOPLE OF AFRICAN ANCESTRY OUTSIDE OF THE USA?
POS-225 ESTIMATED GLOMERULAR FILTRATION RATE EQUATIONS: DO WE NEED TO USE THE ETHNICITY CORRECTION FACTOR IN PEOPLE OF AFRICAN ANCESTRY OUTSIDE OF THE USA? Open
Assessment in African populations suggest adjustment for ethnicity in estimated glomerular filtration rate (eGFR) equations derived from African Americans lead to overestimation of GFR and failure to determine severity in chronic kidney di…
View article: Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia
Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia Open
Fibrosis is the pathophysiological hallmark of progressive chronic kidney disease (CKD). The kidney is a highly metabolically active organ, and it has been suggested that disruption in its metabolism leads to renal fibrosis. We developed a…