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View article: The role of the extracellular matrix protein SPOCK2 for bone physiology and hematopoiesis
The role of the extracellular matrix protein SPOCK2 for bone physiology and hematopoiesis Open
The bone marrow microenvironment (BMM) consists of different cellular and acellular components. These components synergize in regulating the process of hematopoiesis. Various extracellular matrix proteins are found amongst the acellular co…
View article: IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis Open
Expression of interleukin (IL)-17 family cytokines is associated with tumor-promoting inflammation. We found that low expression of IL17RA associated with worse prognosis in late-stage colorectal cancer (CRC) patients. Deletion of Il17ra i…
View article: Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade Open
Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, w…
View article: Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy Open
T memory stem cells (TSCM) display increased self-renewal and prolonged survival capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell responses. TSCM cells can be expanded by Uroli…
View article: Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer Open
Standard cancer therapy targets tumor cells without considering possible damage on the tumor microenvironment that could impair therapy response. In rectal cancer patients we find that inflammatory cancer-associated fibroblasts (iCAFs) are…
View article: Fructose stimulated de novo lipogenesis is promoted by inflammation
Fructose stimulated de novo lipogenesis is promoted by inflammation Open
View article: Fungi Enter the Stage of Colon Carcinogenesis
Fungi Enter the Stage of Colon Carcinogenesis Open
View article: Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent
Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent Open
β-selection is the most pivotal event determining αβ T cell fate. Here, surface-expression of a pre-T cell receptor (pre-TCR) induces thymocyte metabolic activation, proliferation, survival and differentiation. Besides the pre-TCR, β-selec…
View article: Author response: Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent
Author response: Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract β-selection is the most pivotal …
View article: IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice
IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice Open
Key Points Itpkb produces the soluble messenger IP4, which limits cytokine-induced Akt/mTORC1 activation in HSC. Itpkb loss in mice activates HSC and impairs their longevity and function, resulting in lethal hematopoietic failure and anemi…