Claire E. Witherel
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837 Impact of Autologous, Non-Autologous, Synthetic Tissue Substitutes in Burns 2016-2021: Analysis of National Burn Repository Open
Introduction Over 75 commercially available technologies, skin substitutes (aka cellular and acellular matrix-based products, CAMPs), have been used to manage thermal injuries over the last 20 years. Despite demonstrated long term safety a…
826 Analysis of National Burn Repository: Impact of Dermal Templates in Burn Management 2008 to 2021 Open
Introduction Thermal burn injuries comprise of over 400,000 emergency room visits in the United States each year, with estimated costs of care being over $1 billion. Dermal templates continues to be the only skin substitute on the market i…
87 Impact of Skin Substitute Use for Burns: An Analysis of the ABA National Burn Repository Open
Introduction Skin substitutes provide unique utility for the management of thermal injuries over the last 20 years and have evolved into over 75 available technologies today. They are used for patients where insufficient autograft was lack…
Fabrication of MSC-laden composites of hyaluronic acid hydrogels reinforced with MEW scaffolds for cartilage repair Open
Hydrogels are of interest in cartilage tissue engineering due to their ability to support the encapsulation and chondrogenesis of mesenchymal stromal cells (MSCs). However, features such as hydrogel crosslink density, which can influence n…
Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics Open
Osteoarthritis (OA) is a prevalent chronic whole-joint disease characterized by low-grade systemic inflammation, degeneration of joint-related tissues such as articular cartilage, and alteration of bone structures that can eventually lead …
Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages Open
Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the hallmark of the foreign body response, in which implants become encapsulated in thick fibrous tissue that prevents their proper function. While macropha…
Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis Open
Biomaterial‐mediated inflammation and fibrosis remain a prominent challenge in designing materials to support tissue repair and regeneration. Despite the many biomaterial technologies that have been designed to evade or suppress inflammati…
Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages Open
The ability of octadecylamine-functionalized nanodiamond to promote anti-inflammatory behaviour in macrophages suggests its potential to act as an anti-inflammatory therapeutic.
Differences in time-dependent mechanical properties between extruded and molded hydrogels Open
The mechanical properties of hydrogels used in biomaterials and tissue engineering applications are critical determinants of their functionality. Despite the recent rise of additive manufacturing, and specifically extrusion-based bioprinti…