Claire Harbison
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View article: Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord Open
View article: Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox Open
View article: Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord Open
Development of therapeutic approaches that target specific microglia responses in amyotrophic lateral sclerosis (ALS) is crucial due to the involvement of microglia in ALS progression. Our study identifies the predominant microglia subset …
View article: Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox Open
Alternative splicing is an essential mechanism for diversifying proteins, in which mature RNA isoforms produce proteins with potentially distinct functions. Two major challenges in characterizing the cellular function of isoforms are the l…
View article: Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases
Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases Open
Cerebrospinal fluid (CSF) biomarkers are important for multiple sclerosis (MS) diagnosis. Moreover, absent of autopsy or biopsy tissue, CSF is the most relevant source for studying the immune cells involved in MS pathophysiology. Single-ce…