Claire Hetherington
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View article: Cytokines of the Interleukin-1 superfamily and Interleukin-6 are associated with neuroinflammation and brain injury in Herpes Simplex Virus Encephalitis
Cytokines of the Interleukin-1 superfamily and Interleukin-6 are associated with neuroinflammation and brain injury in Herpes Simplex Virus Encephalitis Open
Early adjunctive anti-inflammatory therapy could modulate the immune response and improve clinical outcomes in Herpes Simplex Virus encephalitis (HSE). However, data on the array of inflammatory mediators to target and the immunomodulatory…
View article: Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies
Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies Open
The blood-brain barrier (BBB) protects the brain from pathogenic microorganisms. Neurologic complications from viral infections, including herpes simplex virus, varicella zoster virus, HIV, Japanese encephalitis virus, and SARS-CoV-2, are …
View article: Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study
Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study Open
View article: Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain
Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain Open
Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected in the brain parenchyma. To model this situation, we developed a novel low-inoculum K…
View article: Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open
View article: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days pos…
View article: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open
Neurological complications occur in a significant proportion of COVID-19 cases. In order to identify key biomarkers, we measured brain injury markers, inflammatory mediators, and autoantibodies in 203 participants admitted to hospital for …
View article: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Open
We measured brain injury markers, inflammatory mediators, and autoantibodies in 203 participants with COVID-19; 111 provided acute sera (1-11 days post admission) and 56 with COVID-19-associated neurological diagnoses provided subacute/con…